Changes in retinal flow density measured by optical coherence tomography angiography in patients with carotid artery stenosis after carotid endarterectomy

Lahme, Larissa; Marchiori, Elena; Panuccio, Giuseppe; Nelis, Pieter; Schubert, Friederike; Mihailovic, Nataša; Torsello, Giovanni; Eter, Nicole; Alnawaiseh, Maged

doi:10.1038/s41598-018-35556-4

Cited by 60 publications

(67 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Assuming that retinal microvasculature changes in response to systemic microvascular function, increased retinal vessel density in both eyes may attribute to the longitudinal effect of medications. In consistent with our findings, a recent study using OCTA observed a reduced vessel density in patients with CAS when compared with healthy controls and the vessel density increased significantly after CEA in the ipsilateral and in the contralateral eye 22 .…”

Section: Discussionsupporting

confidence: 93%

Optical Coherence Tomography Angiography Evaluation of Retinal Microvasculature Before and After Carotid Angioplasty and Stenting

Lee

Cheng

Chang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

The aim of the study was to evaluate the influence of carotid angioplasty and stenting (CAS) on retinal microvasculature using optical coherence tomography angiography (OCTA) in patients with severe carotid stenosis. 20 patients with severe carotid stenosis underwent comprehensive ophthalmic examinations and OCTA before and one month after CAS. Automated algorithms were used to quantify vessel density in the macular superficial vascular complex (SVC), deep vascular complex (DVC), and radial peripapillary capillary (RPC) around the optic disc. Eyes on the operated side constituted the ipsilateral eye group, and the other eye constituted the fellow eye group. In the ipsilateral eye group, the vessel density in the DVC increased significantly after stent implantation (P = 0.010), but the vessel density change in the SVC was not statistically different (P = 0.999). In the fellow eye group, the vessel density in the SVC (P = 0.028) and DVC (P = 0.034) were significantly increased after stent implantation. The vessel density in the RPC did not significantly change in the ipsilateral (P = 0.363) or fellow (P = 0.878) eye groups. This study shows that unilateral CAS for severe carotid stenosis increases macular vessel densities in both eyes.

show abstract

Section: Discussionsupporting

confidence: 93%

Optical Coherence Tomography Angiography Evaluation of Retinal Microvasculature Before and After Carotid Angioplasty and Stenting

Lee

Cheng

Chang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, only one investigation has been conducted in order to assess OCTA changes in CAS patients ( Lahme et al, 2018 ). This study agreed in terms of including only asymptomatic patients, although their follow-up was limited just to 3–4 days after surgery, whereas our follow-up was longer ( Lahme et al, 2018 ). This previous investigation disclosed similar results regarding RPC blood flow impairment before surgery and its restoration after endarterectomy in the ipsilateral.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Optical Coherence Tomography Angiography Detects Retinal Perfusion Changes in Carotid Artery Stenosis

Pierro¹,

Arrigo²,

Crescenzo³

et al. 2021

Front. Neurosci.

View full text Add to dashboard Cite

BackgroundCarotid artery stenosis (CAS) is a multifaceted disease characterized by possible ocular involvement. Treatment with carotid endarterectomy helps to restore cerebral perfusion, which may prevent ocular and cerebral complications. The main aim was to assess retinal and choroidal vascular perfusion changes before and after endarterectomy in patients affected by CAS.MethodsThe design of the study was prospective and observational, including patients affected by CAS and healthy controls. The follow-up was 3 months. We performed quantitative optical coherence tomography (OCT) angiography (OCTA) analyses of retinal perfusion changes, before and after endarterectomy. The main outcome measures were the quantitative changes of choroidal thickness (CT), retinal nerve fiber layer (RNFL), and ganglion cell layer (GCL); vessel density (VD); and vessel tortuosity (VT) OCTA metrics were also measured.ResultsSixty eyes of 30 patients affected by CAS and 30 eyes of 30 controls were included. We separately considered the ipsilateral eyes to CAS, the contralateral eyes to CAS, and the healthy eyes. Visual symptoms were absent in all the patients. RNFL and GCL resulted similar between patients and controls (p > 0.05). CT was significantly thinner in ipsilateral eyes than controls (p < 0.01), and it resulted unchanged after surgery (p > 0.05). VD resulted significantly altered only in some plexa of the ipsilateral eyes (p < 0.01), whereas VT disclosed decreased values of the entire retinal vascular network, both in ipsilateral and contralateral eyes (p < 0.05). Endarterectomy was followed by statistically significant improvement of retinal perfusion (p < 0.05).ConclusionOptical coherence tomography angiography can noninvasively detect postendarterectomy retinal perfusion improvements in CAS patients with baseline diabetes and hypertension as a systemic risk factor.

show abstract

“…With the development of new technology in ophthalmology, many potential lesions can be detected before visible fundus diseases occur. Asymptomatic patients with carotid stenosis were found to have reduced retinal vascular density (Lahme et al 2018), thin retinal nerve fibre layers (Wang et al 2017a), and reduced and delayed electroretinographic responses (Kofoed et al 2013), suggesting that carotid stenosis affects the microstructure and function of the retina. However, whether carotid artery stenosis affects retinal oxygen metabolism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Retinal vessel oxygen saturation in patients with unilateral internal carotid artery stenosis: a pilot study

Zhang

Zou

et al. 2020

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose To investigate the retinal vessel oxygen saturation in patients with internal carotid artery stenosis (ICAS). Methods This is a cross‐sectional study. Sixteen patients with unilateral moderate or worse ICAS (≥50%) and no fundus diseases were included in the study. Sixteen gender‐ and age‐matched healthy subjects were selected as controls. The mean oxygen saturation and vessel diameters of the retinal arterioles and venules were obtained using a dual‐wavelength spectrophotometric retinal oximeter. Results In the eye of the stenotic side, the retinal vessel oxygen saturation was 100.14 ± 10.27% in the arterioles and 56.50 ± 10.79% in the venules, and the arteriovenous (A‐V) difference was 43.63 ± 7.71%. In the eye of the contralateral side, the oxygen saturation was 96.55 ± 7.50% in the arterioles and 57.42 ± 9.84% in the venules, and the A‐V difference was 39.39 ± 6.33%. In healthy subjects, the oxygen saturation was 93.22 ± 5.98% in the arterioles and 56.57 ± 7.05% in the venules, and the A‐V difference was 36.65 ± 7.33%. The arteriolar oxygen saturation in the stenotic side was higher than that in the contralateral side (p = 0.025) and that in the healthy subjects (p = 0.027), and the A‐V difference in the stenotic side was significantly higher than that in the contralateral side (p = 0.009) and that in the healthy subjects (p = 0.013). The diameters of the arterioles in the stenotic side were smaller than those in the healthy subjects (p = 0.030). Conclusions Patients with ICAS had decreased retinal arteriole diameters and increased retinal vessel oxygen saturation in the arterioles and A‐V differences, suggesting the presence of microcirculation disorder and hyperoxia in the retina.

show abstract

Changes in retinal flow density measured by optical coherence tomography angiography in patients with carotid artery stenosis after carotid endarterectomy

Cited by 60 publications

References 28 publications

Optical Coherence Tomography Angiography Evaluation of Retinal Microvasculature Before and After Carotid Angioplasty and Stenting

Optical Coherence Tomography Angiography Evaluation of Retinal Microvasculature Before and After Carotid Angioplasty and Stenting

Quantitative Optical Coherence Tomography Angiography Detects Retinal Perfusion Changes in Carotid Artery Stenosis

Retinal vessel oxygen saturation in patients with unilateral internal carotid artery stenosis: a pilot study

Contact Info

Product

Resources

About