Changes in S1 Neural Responses During Tactile Discrimination Learning

Wiest, Michael; Thomson, Eric E.; Pantoja, Janaina; Nicolelis, Miguel A. L.

doi:10.1152/jn.00194.2010

Cited by 54 publications

(87 citation statements)

References 49 publications

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“…Interhemispheric connections between the barrel fields were described by Olavarria et al (1984) and Koralek et al (1990) in the rat, who found that they are confined to the septal regions. The work on unanesthetized rats by Shuler et al (2001) and Wiest et al (2010) found a proportion of units that responded to stimulation of vibrissae from either side of the muzzle in layer V of the barrel cortex. Bilateral subthreshold receptive fields were also described in that layer by Manns et al (2004).…”

Section: Discussionmentioning

confidence: 99%

Bilateral Plasticity of Vibrissae SII Representation Induced by Classical Conditioning in Mice

Dębowska¹,

Liguz-Lecznar²,

Kossut³

2011

J. Neurosci.

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The somatosensory cortex in mice contains primary (SI) and secondary (SII) areas, differing in somatotopic precision, topographic organization, and function. The role of SII in somatosensory processing is still poorly understood. SII is activated bilaterally during attentional tasks and is considered to play a role in tactile memory and sensorimotor integration. We measured the plasticity of SII activation after associative learning based on classical conditioning, in which unilateral stimulation of one row of vibrissae was paired with a tail shock. The training consisted of three daily 10 min sessions, during which 40 pairings were delivered. Cortical activation driven by stimulation of vibrissae was mapped with 2-[ 14 C]deoxyglucose (2DG) autoradiography 1 d after the end of conditioning. We reported previously that the conditioning procedure resulted in unilateral enlargement of 2DG-labeled cortical representation of the "trained" row of vibrissae in SI. Here, we measured the width and intensity of the labeled region in SII. We found that both measured parameters in SII increased bilaterally. The increase was observed in cortical layers II/III and IV. Apparently, plasticity in SII is not a simple reflection of changes in SI. It may be attributable to bilateral integrative role of SII, its lesser topographical specificity, and strong involvement in attentional processing.

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Section: Discussionmentioning

confidence: 99%

Bilateral Plasticity of Vibrissae SII Representation Induced by Classical Conditioning in Mice

Dębowska¹,

Liguz-Lecznar²,

Kossut³

2011

J. Neurosci.

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“…By lowering the minimal synaptic input required to generate cell firing, LLPIE could contribute to the strengthening of cortical responsiveness observed following repeated coactivation of specific whiskers or behavioral training (Diamond et al, 1994;Wiest et al, 2010). In addition, as shown in hippocampus (Cudmore et al, 2010), the enhanced spike-time precision after LLPIE induction could increase the propensity for synchronization in the cortical network.…”

Section: Functional Implications Of Bidirectional Intrinsic Plasticitymentioning

confidence: 99%

“…In the adult somatosensory cortex, the preferential use of a subset of whiskers (Diamond et al, 1993;1994), or the pairing of whisker stimuli with positive or negative reinforcement (Siucinska and Kossut, 1996;, alter the neuronal responses to the trained whiskers. Changes in responsive properties of layer 5 cortical neurons also occur during learning of a whisker-dependent discrimination task and contribute to improvement in the discrimination performance (Wiest et al, 2010). This adaptation of cortical responsiveness likely involves plasticity of synaptic connections within the different layers of barrel cortex (Fox, 2002;Jacob et al, 2007, Skibinska-Kijek et al, 2008Feldman, 2009).…”

Section: Introductionmentioning

confidence: 99%

Bidirectional Plasticity of Intrinsic Excitability Controls Sensory Inputs Efficiency in Layer 5 Barrel Cortex Neuronsin Vivo

Mahon

Charpier

2012

J. Neurosci.

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Responsiveness of cortical neurons to sensory inputs can be altered by experience and learning. While synaptic plasticity is generally proposed as the underlying cellular mechanism, possible contributions of activity-dependent changes in intrinsic excitability remain poorly investigated. Here, we show that periods of rhythmic firing in rat barrel cortex layer 5 pyramidal neurons can trigger a long-lasting increase or decrease in their membrane excitability in vivo. Potentiation of cortical excitability consisted of an increased firing in response to intracellular stimulation and a reduction in threshold current for spike initiation. Conversely, depression of cortical excitability was evidenced by an augmented firing threshold leading to a reduced current-evoked spiking. The direction of plasticity depended on the baseline level of spontaneous firing rate and cell excitability. We also found that changes in intrinsic excitability were accompanied by corresponding modifications in the effectiveness of sensory inputs. Potentiation and depression of cortical neuron excitability resulted, respectively, in an increased or decreased firing probability on whisker-evoked synaptic responses, without modifications in the synaptic strength itself. These data suggest that bidirectional intrinsic plasticity could play an important role in experience-dependent refinement of sensory cortical networks.

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“…Although the behaviour strategy used by the animal ('active sensing' versus 'detection amid distractors') 22,24 cannot be distinguished, our activation patterns are in line with previous reports indicating that S1-M1 integration may inform the decision of the mouse under this task condition [18][19][20] . As sensory stimulus features alone are not sufficient to produce these differential activation patterns among S2P and M1P neurons, we speculate that other mechanisms could be involved, including plasticity of local and long-range circuits during task learning 27,28 or topdown influences exerted by feedback circuits or attention-related brain areas during task engagement 29,30 . Understanding the circuits and mechanisms underlying this selective routing of sensory information will warrant further investigation.…”

mentioning

confidence: 99%

Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex

Chen

Carta

Soldado-Magraner

et al. 2013

Nature

326

361

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In the mammalian neocortex, segregated processing streams are thought to be important for forming sensory representations of the environment, but how local information in primary sensory cortex is transmitted to other distant cortical areas during behaviour is unclear. Here we show task-dependent activation of distinct, largely non-overlapping long-range projection neurons in the whisker region of primary somatosensory cortex (S1) in awake, behaving mice. Using two-photon calcium imaging, we monitored neuronal activity in anatomically identified S1 neurons projecting to secondary somatosensory (S2) or primary motor (M1) cortex in mice using their whiskers to perform a texture-discrimination task or a task that required them to detect the presence of an object at a certain location. Whisking-related cells were found among S2-projecting (S2P) but not M1-projecting (M1P) neurons. A higher fraction of S2P than M1P neurons showed touch-related responses during texture discrimination, whereas a higher fraction of M1P than S2P neurons showed touch-related responses during the detection task. In both tasks, S2P and M1P neurons could discriminate similarly between trials producing different behavioural decisions. However, in trials producing the same decision, S2P neurons performed better at discriminating texture, whereas M1P neurons were better at discriminating location. Sensory stimulus features alone were not sufficient to elicit these differences, suggesting that selective transmission of S1 information to S2 and M1 is driven by behaviour.

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Changes in S1 Neural Responses During Tactile Discrimination Learning

Cited by 54 publications

References 49 publications

Bilateral Plasticity of Vibrissae SII Representation Induced by Classical Conditioning in Mice

Bilateral Plasticity of Vibrissae SII Representation Induced by Classical Conditioning in Mice

Bidirectional Plasticity of Intrinsic Excitability Controls Sensory Inputs Efficiency in Layer 5 Barrel Cortex Neuronsin Vivo

Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex

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