Changes in serum alpha2 globulins in reticuloses

Malpas, J. S.; Fairley, G. Hamilton

doi:10.1136/jcp.17.6.651

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…Albumin often is reduced, mainly due to a decrease in synthesis.118 Serum alpha-1 , alpha-2 (77% of cases) and beta-2 (35% of cases) globulins often are increased.6, 30, 8 1 T h e increase in the alpha-2 globulins is largely due to an increase of haptaglobin and caeruloplasmin. 69 Although some authors feel that hypogammaglobulinemia is seen only rarely in patients with Hodgkin's disease,39 we have found that hypogammaglobulinemia (< 0.9 Gm per 100 ml) occurs in almost half the cases, particularly in advanced disease; similar findings have been reported by 0thers.~0 Elevation of gamma globulins was seen in over 4001, of our patients.…”

Section: Clinical Featukes and Diagnosis Of Hodgkin's D I~e A~e Ultmannsupporting

confidence: 79%

Clinical features and diagnosis of Hodgkin's disease

Ultmann

1966

Cancer

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This paper briefly summarizes current knowledge of Hodgkin's disease, based on a review of the voluminous recent literature and on the author's observations in 135 cases. Special features of the incidence patterns are noted. The initial clinical findings are described and problems of staging are discussed. Lymphangiographic techniques, as well as radioisotope scanning procedures which can now be used to study the liver, spleen, lung and bone marrow, have added new dimensions to the meaning of “clinically local disease.” The course of the disease is characterized by its great variability and the causes of death are multiple, with infection contributing in a major way. A general approach to therapy is outlined.

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Section: Clinical Featukes and Diagnosis Of Hodgkin's D I~e A~e Ultmannsupporting

confidence: 79%

Clinical features and diagnosis of Hodgkin's disease

Ultmann

1966

Cancer

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“…Several other substances in the plasma are increased in Hodgkin's disease, probably also related to the tumor mass. This applies to such diverse substances as copper (Pagliardi & Giangrandi 1960, Thorling & Thorling 1976), alpha2-globulins, haptoglobin and caeruloplasmin (Malpas & Hamilton Fairley 1964), beta2-microglobulin (Spati et a1 1978), and ferritin (Dorner et a1 1978). No pathophysiological mechanism has been offered for these increases, hence the designation 'nonspecific'.…”

Section: Discussionmentioning

confidence: 99%

Elevated Plasma Lysozyme in Hodgkin's Disease An Indicator of Increased Macrophage Activity?

Hansen

Karle

1979

Scandinavian Journal of Haematology

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Plasma lysozyme levels were studied in 42 patients with Hodgkin's disease and were found significantly increased. Plasma lysozyme varied with the stage of the disease and with symptoms, but did not correlate with the histological subtype or with blood neutrophil and monocyte counts. Serial measurements in four patients on MOPP treatment showed a rapid decrease following treatment. The increased plasma lysozyme in Hodgkin's disease stems most likely from the macrophage system, either because the macrophages are hyperactive and/or because the malignant cell in Hodgkin's disease is of macrophage origin.

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Clinical Course and Complications

Ultmann¹

1973

Arch Intern Med

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Changes in serum alpha2 globulins in reticuloses

Cited by 10 publications

References 9 publications

Clinical features and diagnosis of Hodgkin's disease

Clinical features and diagnosis of Hodgkin's disease

Elevated Plasma Lysozyme in Hodgkin's Disease An Indicator of Increased Macrophage Activity?

Clinical Course and Complications

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