Changes in serum TNF-α, IL-18, and IL-6 concentrations in patients with chronic schizophrenia at admission and at discharge

Luo, Yayan; He, Hongbo; Zhang, Jie; Ou, Yufen; Fan, Ni

doi:10.1016/j.comppsych.2019.01.003

Cited by 59 publications

(31 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Partial least squares (LSD) analysis (Ringle, 2015) (Ringle, 2015). We employed complete bootstrapping (5000 subsamples) and PLS path modeling to compute path coefficients with p-values (Luo, He, Zhang, Ou, & Fan, 2019).…”

Section: Discussionmentioning

confidence: 99%

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Mousa¹,

Al‐Hakeim²,

Alhaidari³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Physiosomatic symptoms are an important part of schizophrenia phenomenology. The aim of this study is to examine the biomarker, neurocognitive and symptomatic correlates of physiosomatic symptoms in schizophrenia. Methods: We recruited 115 schizophrenia patients and 43 healthy controls and measured the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) scale, schizophrenia symptom dimensions, and the Brief Assessment of Cognition in Schizophrenia. We measured neuro-immune markers including plasma CCL11 (eotaxin), interleukin-(IL)-6, IL-10, Dickkopf protein 1 (DKK1), high mobility group box 1 protein (HMGB1) and endogenous opioid system (EOS) markers including κ-opioid receptor (KOR), µ-opioid receptor (MOR), endomorphin-2 (EM2) and β-endorphin. Results: Patients with an increased FF score display increased ratings of psychosis, hostility, excitement, formal though disorders, psychomotor retardation and negative symptoms as compared with patients with lower FF scores. A large part of the variance in the FF score (55.1%) is explained by the regression on digit sequencing task, token motor task, list learning, IL-10, age (all inversely) and IL-6 (positively). Neural network analysis shows that the top-6 predictors of the FF score are (in descending order): IL-6, HMGB1, education, MOR, KOR and IL-10. We found that 45.1% of the variance in a latent vector extracted from cognitive test scores, schizophrenia symptoms and the FF score was explained by HMGB-1, MOR, EM2, DKK1, and CCL11. Conclusions: FF symptoms are an integral part of the phenome of schizophrenia. Neurotoxic immune and neurodegenerative pathways and to a lesser extent the EOS appear to drive FF symptoms in schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Mousa¹,

Al‐Hakeim²,

Alhaidari³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Several inflammatory mediators have been proposed to be implicated in SZ, including interleukin 6 (IL-6) [7, 8]. IL-6 exerts its proinflammatory effects via trans-signaling, binding to the soluble form of the IL-6 receptor (sIL-6R), which is generated by mRNA alternative splicing and partial proteolysis [9].…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine

Cavieres

Campos‐Estrada

Moya

et al. 2019

Schizophrenia Research and Treatment

View full text Add to dashboard Cite

Alterations in neuroinflammatory processes have been suggested to contribute to the development of Schizophrenia (SZ); one component of the inflammatory system that has been linked to this disorder is interleukin-6 (IL-6). The minor allele of rs2228145, a functional polymorphism in the IL-6 receptor gene, has been associated to elevated IL-6 plasma levels and increased inflammatory activity, making it an interesting candidate to study as a possible factor underlying clinical heterogeneity in SZ. We studied a sample of 100 patients undergoing treatment with clozapine. Their symptoms were quantified by Brief Psychotic Rating Scale; those with the lowest scores (“remitted”) were compared with the highest (“clozapine treatment resistant”). We determined allelic frequencies for rs2228145 and IL-6 plasma levels. Our results do not support a role of IL-6 in response to treatment with clozapine. Further studies accounting for potential confounding factors are necessary.

show abstract

“…Previous investigations have shown that the serum levels of some cytokines, such as IL-1β and IL-6, are positively correlated with negative symptoms from the Positive and Negative Symptoms Scale in schizophrenia patients. 32 - 34 Some studies have found that gal-3 regulates the expression levels of cytokines such as IL-1β and IL-6, which are related to the negative symptoms of schizophrenia. 35 , 36 Thus, increases and decreases in cytokine concentrations associated with schizophrenia symptoms might explain the connection we found between serum gal-3 concentrations and negative symptoms of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Serum galectin-3 levels are decreased in schizophrenia

Kılıç

Işık

Demirdaş

et al. 2020

Braz. J. Psychiatry

View full text Add to dashboard Cite

Objective: To determine whether changes in serum galectin-3 (gal-3) concentrations in schizophrenia patients have etiopathogenetic importance. Since very little research has assessed the connection between galectins and schizophrenia, we wanted to examine alterations in the inflammatory marker gal-3 in schizophrenia and investigate possible correlations between clinical symptomatology and serum concentrations. Methods: Forty-eight schizophrenia patients and 44 healthy controls were included in this study. The Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were administered to determine symptom severity. Venous blood samples were collected, and serum gal-3 levels were measured. Results: Mean serum gal-3 levels were significantly lower in schizophrenia patients, and there were no significant differences in age or sex with the control group. There was also a significant positive correlation between serum gal-3 concentrations and negative schizophrenia symptoms according to the SANS. Conclusion:The results indicate that gal-3 is decreased in schizophrenia patients, which could contribute to inflammation in the pathogenesis of schizophrenia.

show abstract

Changes in serum TNF-α, IL-18, and IL-6 concentrations in patients with chronic schizophrenia at admission and at discharge

Cited by 59 publications

References 38 publications

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine

Serum galectin-3 levels are decreased in schizophrenia

Contact Info

Product

Resources

About