2019
DOI: 10.1155/2019/5601249
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Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine

Abstract: Alterations in neuroinflammatory processes have been suggested to contribute to the development of Schizophrenia (SZ); one component of the inflammatory system that has been linked to this disorder is interleukin-6 (IL-6). The minor allele of rs2228145, a functional polymorphism in the IL-6 receptor gene, has been associated to elevated IL-6 plasma levels and increased inflammatory activity, making it an interesting candidate to study as a possible factor underlying clinical heterogeneity in SZ. We studied a s… Show more

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Cited by 3 publications
(2 citation statements)
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“…We found no differences in genotype or allele frequency between patients who remitted with clozapine and those with persistent symptoms. Furthermore, we found no difference in the median interleukin-6 plasma level by genotype ( Cavieres et al, 2019 ). For the present study, we compared the full spectrum of treatment responses, from responsive to refractory.…”
Section: Introductioncontrasting
confidence: 53%
“…We found no differences in genotype or allele frequency between patients who remitted with clozapine and those with persistent symptoms. Furthermore, we found no difference in the median interleukin-6 plasma level by genotype ( Cavieres et al, 2019 ). For the present study, we compared the full spectrum of treatment responses, from responsive to refractory.…”
Section: Introductioncontrasting
confidence: 53%
“…Third, we analyzed the association between the rs2228145 polymorphism of the IL6R gene and individuals with suicide attempts, for the minor allele of the rs2228145 polymorphism (Ala) has been associated with elevated IL-6 levels in the serum and circulating/plasma levels in individuals with schizophrenia [ 48 ]. Then, we considered it important to evaluate the genotypic distribution of the IL6R gene in suicide attempts.…”
Section: Discussionmentioning
confidence: 99%