Changes in severity of depressive symptoms and mortality: the Italian Longitudinal Study on Aging

Scafato, Emanuele; Galluzzo, Lucia; Ghirini, Silvia; Gandin, Claudia; Rossi, A.; Solfrizzi, Vincenzo; Carlo, Antonio Di; Maggi, Stefania; Farchi, G

doi:10.1017/s0033291712000645

Cited by 17 publications

(23 citation statements)

References 30 publications

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“…While there are studies looking at the impact of socioeconomic status on parasuicide [43], suicide [40,44] and cause of death in major depressive disorder [45,46], generalised anxiety disorder [47] and alcohol misuse [48], we found only one study which specifically focused on the impact of socioeconomic status on mortality in bipolar disorder [49] and no studies which specifically focused on the impact of socioeconomic status on mortality in schizophrenia. The study which explored the impact of socioeconomic factors on cause and rate of death in affective disorders was limited due its small sample size of only 30 deaths.…”

Section: Discussionmentioning

confidence: 98%

Impact of socioeconomic deprivation on rate and cause of death in severe mental illness

et al. 2014

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BackgroundSocioeconomic status has important associations with disease-specific mortality in the general population. Although individuals with Severe Mental Illnesses (SMI) experience significant premature mortality, the relationship between socioeconomic status and mortality in this group remains under investigated. We aimed to assess the impact of socioeconomic status on rate and cause of death in individuals with SMI (schizophrenia and bipolar disorder) relative to the local (Glasgow) and wider (Scottish) populations.MethodsCause and age of death during 2006-2010 inclusive for individuals with schizophrenia or bipolar disorder registered on the Glasgow Psychosis Clinical Information System (PsyCIS) were obtained by linkage to the Scottish General Register Office (GRO). Rate and cause of death by socioeconomic status, measured by Scottish Index of Multiple Deprivation (SIMD), were compared to the Glasgow and Scottish populations.ResultsDeath rates were higher in people with SMI across all socioeconomic quintiles compared to the Glasgow and Scottish populations, and persisted when suicide was excluded. Differences were largest in the most deprived quintile (794.6 per 10,000 population vs. 274.7 and 252.4 for Glasgow and Scotland respectively). Cause of death varied by socioeconomic status. For those living in the most deprived quintile, higher drug-related deaths occurred in those with SMI compared to local Glasgow and wider Scottish population rates (12.3% vs. 5.9%, p = <0.001 and 5.1% p = 0.002 respectively). A lower proportion of deaths due to cancer in those with SMI living in the most deprived quintile were also observed, relative to the local Glasgow and wider Scottish populations (12.3% vs. 25.1% p = 0.013 and 26.3% p = <0.001). The proportion of suicides was significantly higher in those with SMI living in the more affluent quintiles relative to Glasgow and Scotland (54.6% vs. 5.8%, p = <0.001 and 5.5%, p = <0.001).ConclusionsExcess mortality in those with SMI occurred across all socioeconomic quintiles compared to the Glasgow and Scottish populations but was most marked in the most deprived quintiles when suicide was excluded as a cause of death. Further work assessing the impact of socioeconomic status on specific causes of premature mortality in SMI is needed.

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Section: Discussionmentioning

confidence: 98%

Impact of socioeconomic deprivation on rate and cause of death in severe mental illness

et al. 2014

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“…While the prevalence of major depression (MDD) is relatively low (1.8%), the prevalence of all clinically relevant depressive syndromes, some of which do not fully fulfill criteria for MDD, is high (13.5%) in community dwelling elderly (Beekman et al, 1999). Both may have detrimental consequences for the wellbeing and functioning of older persons, and are associated with increased mortality (Alexopoulos, 2005;Cuijpers et al, 2013;Scafato et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Serum insulin-like growth factor 1 and late-life depression: A population-based study

Varsseveld

Bunderen

Sohl

et al. 2015

Psychoneuroendocrinology

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“…However, in most studies depressive symptoms are exclusively measured at a single time point [6,8,12], which may not entail the periodic long-term episodes and cumulative effect on mortality risk [14]. Only a few studies have investigated the relationship between repeated measurements of depressive symptoms and the risk of cardiovascular outcomes and all-cause mortality [15,16]. For instance, in the Italian Longitudinal Study of Aging cohort, depressive symptoms were only measured at baseline and the second survey at 3 years after the baseline [16] clearly demonstrating the lack of interval-reproducible depressive episodic outcomes within the given long-term time frame.…”

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confidence: 99%

Time-dependent depressive symptoms and risk of cardiovascular and all-cause mortality among the Chinese elderly: The Beijing Longitudinal Study of Aging

Halm‐Lutterodt

Zheng

et al. 2018

Journal of Cardiology

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Changes in severity of depressive symptoms and mortality: the Italian Longitudinal Study on Aging

Cited by 17 publications

References 30 publications

Impact of socioeconomic deprivation on rate and cause of death in severe mental illness

Impact of socioeconomic deprivation on rate and cause of death in severe mental illness

Serum insulin-like growth factor 1 and late-life depression: A population-based study

Time-dependent depressive symptoms and risk of cardiovascular and all-cause mortality among the Chinese elderly: The Beijing Longitudinal Study of Aging

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