MODERATE degrees of iron deficiency in late pregnancy are difficult to recognize by simple haematological methods. There is little, if any, correlation between the total red cell volume and the peripheral venous haematocrit at this time (Roscoe and Donaldson, 1946;Lund and Sisson, 1958).It was therefore decided to assess the methods available for detecting iron deficiency which were independent of the peripheral haemoglobin concentration and haematocrit. For comparison the total blood volume and the peripheral haemoglobin concentration changes for each individual were measured simultaneously.Many methods have been used to assess the * This work formed part of a thesis accepted for the 100 per cent Haldane=14-8 g./100 ml. of degree of Doctor of Medicine in the University of blood) and the mean corpuscular haemoglobin London.Royal Infirmary.
per cent).
METHODS
ASSESSMENT OF IRON STATUSOf Red cells t present address, Clinical Laboratory, ManChester concentration 32 ' 15 per cent (standard deviation 29 3 Wintrobe, M. M. (1956): Clinical Hematology. 4th 307.1 192.J . d i n . Invest., 28, 487. Anier. med. Ass., 149, 1 127. Gynec., 77, 731. Rev., 26, 855. Brit. med. J., 1, 463. Med., 93, 725.
J .Conroy, L. (1950): Surg. Gynec. Obstet., 90, 320.
33, 81.Obstet. Gynaec. Brit. Emp., 53, 430.
807.Brit. Emp., 58, 173.edition. Kimpton, London.