Changes in testicular histology and sperm quality in llamas (Lama glama), following exposure to high ambient temperature

Schwalm, Anja; Gauly, Matthias; Erhardt, G.; Bergmann, Martin

doi:10.1016/j.theriogenology.2007.02.005

Cited by 30 publications

(24 citation statements)

References 26 publications

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“…Data are Means + SD, n ¼ 10. Schwalm et al, 2007;Pérez-Crespo et al, 2008;Paul et al, 2008aPaul et al, ,b, 2009). However, these authors evaluated the effect of different heat stress ranging from 29 to 43 8C observed in a variety of conditions: whole body, lower third of the body or just scrotal heating, in men and in conscious or anaesthetised animal models.…”

Section: Figurementioning

confidence: 99%

Seminal and molecular evidence that sauna exposure affects human spermatogenesis

et al. 2013

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study question: What are the effects of continuous sauna exposure on seminal parameters, sperm chromatin, sperm apoptosis and expression of genes involved in heat stress and hypoxia?summary answer: Scrotal hyperthermia by exposure to sauna can induce a significant alteration of spermatogenesis. what is known already: Several authors have evidenced that high temperature has dramatic effects on spermatogenesis. study design, size and duration: A longitudinal time-course study. Data from 10 subjects exposed to Finnish sauna were collected before sauna (T0), after3 months of sauna sessions (T1) and after 3 (T2) and 6 months (T3) from the end of sauna exposure.participants/materials, setting and methods: Ten normozoospermic volunteers underwent two sauna sessions per week for 3 months, at 80 -908C, each lasting 15 min. Sex hormones, sperm parameters, sperm chromatin structure, sperm apoptosis and expression of genes involved in heat stress and hypoxia were evaluated at the start, at the end of sauna exposure and after 3 and 6 months from sauna discontinuation. Student's t-test for paired data was used for statistical analysis.main results and the role of chance: At the end of sauna exposure, we found a strong impairment of sperm count and motility (P , 0.001), while no significant change in sex hormones was present. Decreases in the percentage of sperm with normal histoneprotamine substitution (78.7 + 4.5 versus 69.0 + 4.1), chromatin condensation (70.7 + 4.7 versus 63.6 + 3.3) and mitochondrial function (76.8 + 4.9 versus 54.0 + 6.1) were also evident at T1, and strong parallel up-regulation of genes involved in response to heat stress and hypoxia was found. All these effects were completely reversed at T3.limitations and reasons for caution: Absence of subjects with abnormal sperm parameters was the major limitation of this study.wider implications of the findings: Our data demonstrated for the first time that in normozoospermic subjects, sauna exposure induces a significant but reversible impairment of spermatogenesis, including alteration of sperm parameters, mitochondrial function and sperm DNA packaging. The large use of Finnish sauna in Nordic countries and its growing use in other parts of the world make it important to consider the impact of this lifestyle choice on men's fertility. study funding/competing interest(s): No external funding was sought for this study and the authors have no conflict of interest to declare.

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Section: Figurementioning

confidence: 99%

Seminal and molecular evidence that sauna exposure affects human spermatogenesis

et al. 2013

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“…Many studies have shown that HS could affect the reproductive function in animals. For example, HS could result in the decrease of sperm concentration and increase of abnormal sperm cells in llamas (Schwalm et al, 2007). HS could also affect the germ cell DNA integrity in mice (Paul et al, 2009) and increase testicular germ cell apoptosis in rats (Kanter et al, 2013) and cynomolgus monkeys (Lue et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Metabolomic profiles reveal key metabolic changes in heat stress-treated mouse Sertoli cells

Chen

et al. 2015

Toxicology in Vitro

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“…In general, Ki-67 protein is a cell proliferative marker (Steger et al, 1998;Whitfield et al, 2006;Angelopoulou et al, 2008). In testis, it presents in the nuclei of spermatogonia and Sertoli cells (Steger et al;Schwalm et al, 2007). For immunohistochemistry of antiKi-67 protein result in this study, this protein was also detected in nuclei of spermatogonia and Sertoli cells (Fig.…”

Section: Discussionmentioning

confidence: 56%

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

et al. 2017

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SITTHICHAI, I.; WANNISA, S.; APICHAKARN, S. & BUNGORN, S.Protective effect of Momordica cochinchinensis (L.) spreng aril extract on essential testicular markers in rats induced with valproic acid. Int. J. Morphol., 35(3):992-999, 2017. SUMMARY:Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before coadministration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and expression of androgen receptor (AR), Ki-67, tyrosine phosphorylated proteins, and steroidogenic proteins in testis were examined. The results showed that MC could prevent all reproductive parameters in VPA-treated rats. Moreover, MC+VPA groups showed significant declining of testicular histopathologies compared to VPA group. It also decreased the malondialdehyde level and changes of the testicular StAR, AR, and tyrosine phosphorylated protein expressions. In conclusion, M. cochinchinensis aril extract can prevent adverse male reproductive parameters and essential testicular proteins damages induced with VPA.

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Changes in testicular histology and sperm quality in llamas (Lama glama), following exposure to high ambient temperature

Cited by 30 publications

References 26 publications

Seminal and molecular evidence that sauna exposure affects human spermatogenesis

Seminal and molecular evidence that sauna exposure affects human spermatogenesis

Metabolomic profiles reveal key metabolic changes in heat stress-treated mouse Sertoli cells

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

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