Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

Avdeev, O. V.; Drevnitska, R. O.; Gevkaliuk, N.; Bandrivsky, Yu.; Boykiv, A. B.

doi:10.15407/ubj94.05.059

Ukr.Biochem.J.

2022

DOI: 10.15407/ubj94.05.059

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Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

O. V. Avdeev¹,

R. O. Drevnitska²,

N. Gevkaliuk³

et al.

Abstract: The aim of the study was to evaluate changes in the activity of acid and alkaline phosphatases, calcium and phosphorus levels in rats with different courses of experimental gingivitis upon treatment with anti-inflammatory gel with Neovitin and peptide complexes. The experiment was conducted on 100 white nonlinear male rats aged 5-6 months divided into 10 groups: 1 control and 9 – with different courseі of gingivitis. The activity of alkaline and acid phosphatase (ALP, ACP), the levels of calcium (Ca) and phosp… Show more

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Cited by 4 publications

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The State of Periodontal Tissues in Military Personnel of the Armed Forces of Ukraine Depending on the Psycho-Emotional State

Bilan,

Bandrivsky

2024

EUMJ

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The aim of the study: To assess the periodontal tissue condition of military personnel in the Armed Forces of Ukraine based on their psycho-emotional state. Materials and methods. A periodontal examination was conducted on 142 male military personnel of the Armed Forces of Ukraine who were undergoing rehabilitation or were on rotation, in order to achieve the stated goal. The age range of the subjects was 27 to 60 years, and their period of stay in the combat zone ranged from 3 months to 2 years. The patients underwent clinical and dental examination according to a standardized scheme, which included taking anamnesis and analyzing patients' complaints. The periodontal tissue condition was assessed using Danilevsky's M.F. (1994) classification, with additions by Mashchenko I.S. (2002). To identify symptoms of post-traumatic stress disorder (PTSD) in military personnel of the Armed Forces of Ukraine, we administered the PSL-5 questionnaire developed by the National Centre for PTSD. We also determined the presence and degree of psychoemotional stress in the study group using the methodology of Holmes T.H. and Rahe R.H. (1967). The level of reactive and personal anxiety was measured using the Spielberger-Hanin method, specifically the State-Trait Anxiety Inventory (STAI) from 1970. Results. The study found that the presence of PTSD in military personnel of the Armed Forces of Ukraine intensifies periodontal tissue diseases. This is shown by an increase in advanced forms of generalized periodontitis (19.74±4.50 % of patients with PTSD vs. 5.00±4.87 % of patients without PTSD, p<0.01) and a minimal frequency of detection of inflammatory diseases of periodontal tissues (p<0.05). The study examined the correlation between periodontal tissue diseases and stress resistance and reactive anxiety levels in military personnel of the Armed Forces of Ukraine. The results showed that patients with a very high and high degree of stress resistance and a low level of reactive anxiety (I, II groups) exhibited a greater degree of resistance to stress. No changes were made to the original text as it already adheres to the desired characteristics. Inflammatory diseases were found to be more prevalent in the structure of periodontal diseases. Meanwhile, dystrophic-inflammatory lesions of periodontal tissues were more common in individuals with threshold resistance to stress and moderate reactive anxiety (III group) and those with low resistance to stress and high levels of reactive anxiety (IV group). Conclusions. The study found a close relationship between the psychoemotional disorders of the subjects and the condition of their periodontal tissues. This relationship is likely one of the leading factors that determine the intensity and severity of inflammatory and dystrophic-inflammatory diseases of periodontal tissues in this cohort of patients.

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The State of Periodontal Tissues in Military Personnel of the Armed Forces of Ukraine Depending on the Psycho-Emotional State

Bilan,

Bandrivsky

2024

EUMJ

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Modern views on the etiology and role of microbial persistence in the development of inflammatory processes in the periodontal complex (review)

Marfiian,

Demkovych,

Bondarenko

et al. 2024

Medicni Perspektivi

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Alveolar tissue diseases cause the appearance of dentition defects, thereby reducing the patients' work capacity and quality of life. The purpose of this research was to investigate, modern views on the etiology of periodontitis and the role of microbial persistence in the development of inflammatory processes of periodontal complex basing on a review of literary sources. Literature review was conducted using PubMed, Web of Science, Scopus, Google Scholar from 2018 to March 2024. There were no restrictions on the date of publication or the language of scientific sources. Searches were conducted according to MeSH (Medical Subject Headings) with using the following search terms: "periodontitis", "oral mucosa", "gums", "dental plaque", "periodontium", "traumatic occlusion", "microorganisms". In total, during the initial analysis 82 literary sources were selected and processed, after further systematization of the selected information using general scientific methods, 70 of them remained. Used methods: bibliographic and analytical. Generalized periodontitis is a chronic inflammatory-dystrophic process that occurs as a result of various factors. In the pathogenesis of this disease, the key role is played by the inflammatory process, which is a complex interaction of microcirculatory, hematological and connective tissue reactions to the lesion. Local (exogenic) and general (endogenic) causative factors are distinguished. The main factors that cause pathological changes in periodontium are bacterial biofilm, traumatic occlusion and various anatomical anomalies. Dental plaque occupies a special and main place among the causes of periodontitis. At present, leading pathogenetic links in the development of the inflammation in the periodontium, in particular, the disruption of free radical oxidation, the processes of peroxide oxidation of lipids and proteins, the disorder of the functional state of the antioxidant system, the formation of oxidative stress, as well as the humoral link of adaptive immune protection and cytokinesis, have not been sufficiently studied. There is no doubt about the role of the microbial factor in the etiology of periodontal diseases, but the penetration of microbes into the periodontium does not always lead to the development of the disease, because the organism has a number of protective mechanisms that counteract the development of inflammation.

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Medication correction of the main clinical symptoms of generalized periodontitis in patients with different blood groups

Bandrivsky,

Bandrivska,

Bandrivska

et al. 2023

PHAR

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The article presents the results of treatment of 106 patients with generalized periodontitis (GP) depending on blood type. We determined the effectiveness of treatment by the frequency of detection of the main clinical symptoms (dental plaque, tartar, bleeding, tenderness, gingival hyperemia, serous-purulent discharge, periodontal pockets, pathological tooth mobility, radiological changes in the alveolar membranes) of GP. As a result of applying our proposed therapy, it was found that on day 3–5 after treatment only in patients with blood group 0 (I) of the main group the number of patients with clinical symptoms of GP was significantly less than in the control group (13.58±3.39% of patients vs. 25.69±6.42% of patients, p<0.01, respectively). At 1 month after treatment, there was a significant difference in the presence of clinical symptoms of GP in patients with blood group 0 (I) of the main and control groups (6.17±1.53% vs. 21.58±5.40%, p<0.05, respectively) and with blood group B (III) (8.33±2.08% vs. 22.22±5.56%, p<0.05, respectively). In patients with A (II) and AB (IV) blood groups, the number of patients with symptoms of GP in the study groups did not differ from each other during this follow-up period, p>0.05. After 6–12 months of study, in patients with GP, regardless of blood group, the number of patients in the main group with clinical symptoms of GP was significantly lower than in the control group, p<0.01. The improvement of clinical symptoms in patients with generalized periodontitis indicates a positive effect on the periodontal tissue the medicines we have prescribed.

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Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

Cited by 4 publications

References 15 publications

The State of Periodontal Tissues in Military Personnel of the Armed Forces of Ukraine Depending on the Psycho-Emotional State

The State of Periodontal Tissues in Military Personnel of the Armed Forces of Ukraine Depending on the Psycho-Emotional State

Modern views on the etiology and role of microbial persistence in the development of inflammatory processes in the periodontal complex (review)

Medication correction of the main clinical symptoms of generalized periodontitis in patients with different blood groups

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