Changes in the Activity of Glutathione Peroxidase in the Blood Plasma and Serum of Rats during Postnatal Development and Aging

Razygraev, A. V.; Petrosyan, M. A.; Tumasova, Zh.N.; Taborskaya, K. I.; Polyanskikh, Lyudmila S.; Baziian, E V; Balashova, N. N.

doi:10.1134/s2079057019030147

Cited by 2 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased activity of GPx1 can also inhibit H 2 O 2 -induced apoptotic and the related LI-catalysed necrotic cell death [186][187][188][189]. Selenium consumption has also been linked with a decrease in GPx ctiveity, as observed in rat plasma in extreme old age, and this may be used as an indicator of physiological aging [190].…”

Section: Glutathione and Thioredoxin Antioxidant Systems In The Skinmentioning

confidence: 99%

Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants

Pourzand

Albieri-Borges²,

Raczek³

2022

Antioxidants

View full text Add to dashboard Cite

Reactive oxygen species (ROS) are necessary for normal cell signaling and the antimicrobial defense of the skin. However excess production of ROS can disrupt the cellular redox balance and overwhelm the cellular antioxidant (AO) capacity, leading to oxidative stress. In the skin, oxidative stress plays a key role in driving both extrinsic and intrinsic aging. Sunlight exposure has also been a major contributor to extrinsic photoaging of the skin as its oxidising components disrupt both redox- and iron-homeostasis, promoting oxidative damage to skin cells and tissue constituents. Upon oxidative insults, the interplay between excess accumulation of ROS and redox-active labile iron (LI) and its detrimental consequences to the skin are often overlooked. In this review we have revisited the oxidative mechanisms underlying skin damage and aging by focussing on the concerted action of ROS and redox-active LI in the initiation and progression of intrinsic and extrinsic skin aging processes. Based on these, we propose to redefine the selection criteria for skin antiaging and photoprotective ingredients to include natural antioxidants (AOs) exhibiting robust redox–balancing and/or iron-chelating properties. This would promote the concept of natural-based or bio-inspired bifunctional anti-aging and photoprotective ingredients for skincare and sunscreen formulations with both AO and iron-chelating properties.

show abstract

Section: Glutathione and Thioredoxin Antioxidant Systems In The Skinmentioning

confidence: 99%

Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants

Pourzand

Albieri-Borges²,

Raczek³

2022

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Rats serum glutathione peroxidase (GPx)concentration was measured by according to the method of Paglia and Valentine on the principal of DTNB (Razygraev et al 2019).…”

Section: Determination Of Serumglutathione Peroxidase(gpx)mentioning

confidence: 99%

Anti-inflammatory and antioxidant effects of zinc and vitamin D on nicotine-induced oxidative stress in adult male rats

Hamady

Al-Okaily

2022

ijhs

View full text Add to dashboard Cite

Current study aimed to investigation the protective effects of zinc and vitamin D in attenuating alveolar response, as anti-inflammatory and antioxidant, in nicotine stressed male rats. Thirty adult males Wistar rats, as a model of mammals, randomly assigned to five equal groups and treatment as follows for 14 days: Control (C) drenched vehicle without treatment, G1 = injected nicotine 1.5 mg/ kg b.w. i/P, G2 administrated orally of zinc 60 mg/ kg b.w., G3 = administrated orally of vitamin D 250 µg/ kg b.w. and G4 administrated orally both of zinc and vitamin D with same doses and stressed by nicotine 1.5 mg/ kg b.w. i/P. At the end of the experiment, rats were anesthetized blood samples have been collected, and then iron, cytokines (IL-6) and malondialdehyde (MDA) and glutathione peroxidase (GPX) were estimation in in serum and lung tissues. The result showed significant (p ≤ 0.5) increase in serum MDA in group G1 when compared with other groups. While significant (p ≤ 0.5) increase in serum GPx in all treatment group in comparison with nicotine treated group and control.

show abstract

Changes in the Activity of Glutathione Peroxidase in the Blood Plasma and Serum of Rats during Postnatal Development and Aging

Cited by 2 publications

References 12 publications

Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants

Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants

Anti-inflammatory and antioxidant effects of zinc and vitamin D on nicotine-induced oxidative stress in adult male rats

Contact Info

Product

Resources

About