Changes in the Cell Squad of Iliac Lymph Nodes of White Rats in Case of Longterm Influence of Nalbufin

Valko, Olesya; Holovatskyi, А. S.

doi:10.21303/2504-5679.2018.00573

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…We believe that all changes in this term of the experiment are the primary reaction of immune organs to the daily administration of monosodium glutamate, similar changes have been described under the influence of other factors [15,16]. Changes in the vascular bed are non-specific for this organ.…”

Section: Discussionmentioning

confidence: 51%

“…Changes in the vascular bed are non-specific for this organ. Signs of edema of the parenchyma of lymph nodes are that the intercellular space is expanded and contains vacuole-like structures [16].…”

Section: Discussionmentioning

confidence: 99%

“…Changes at the submicroscopic level were found in the lymph nodes during long-term use of the opioid nalbuphine. The authors describe that the six-week and eight-week administration of the opioid nalbuphine leads to pathological changes in the lymph nodes at the submicroscopic level: the number of lymphoblasts with signs of mitosis decreases, the number of lymphocytes with significant nuclear changes and damaged organelles in the cytoplasm of cells increases, which leads to the appearance of lymphoid cells with phenomena of preapoptosis and apoptosis, the intercellular spaces increase [16].…”

Section: Discussionmentioning

confidence: 99%

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Changes in the structural organization of lymph nodes during short-term exposure to monosodium glutamate

et al. 2022

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Monosodium glutamate is a common food additive that belongs to the group of flavor enhancers used in a wide range of food products. The potentially negative impact of monosodium glutamate on human health prompts us to question the safety of its widespread use. The article presents and analyzes the data of an experimental study conducted on 40 white male and female rats of reproductive age (2.5-3.5 months old) weighing 120-190 g. The purpose of the study is to study histological, morphometric, and ultrastructural changes in the lymph nodes of rats under conditions of short-term exposure to monosodium glutamate. An experimental group of animals (10 male rats, 10 female rats), which was on a standard vivarium diet, was given monosodium glutamate at a dose of 0.07 g/kg of rat body weight by pipette every day at the same time for four weeks, followed by free access to water and food. In animals of the intact group, the structure of mesenteric lymph nodes corresponded to the species norm. In the experimental group of animals, after four weeks of monosodium glutamate exposure, it was found that the paracortical area contained a g larger number of post-capillary venules with a high endothelium compared to the intact and control groups of animals. Changes in the vascular bed were established, in particular, the arteries both in the thickness of the organ and in its hilum contain a thickened wall, their lumen is full of blood. Veins are also full-blooded, dilated and deformed. Swelling of the parenchyma of nodes and signs of immune activity are observed. There is a significant decrease in the relative area of lymphoid nodules and the mantle zone, an increase in the relative area of the medullary substance of the node, corticomedullary index, germinal centers, paracortical area, and medullary cords. Part of lymphocytes of all populations with signs of apoptosis. The other part has an uneven karyolemma contour, the nucleolus is not visualized in all lymphocytes, the cytoplasm is clear and contains organelles. Mitochondria are hypertrophied with a light matrix. Therefore, even a short-term daily exposure to monosodium glutamate, namely four weeks, causes changes in the structural organization of mesenteric lymph nodes.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Changes in the structural organization of lymph nodes during short-term exposure to monosodium glutamate

et al. 2022

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“…The current issue is the study of the effect of obesity on organs and tissues, as well as the possibility of correction of these changes [1,14,15]. Of particular interest are the organs of the immune system, in particular lymph nodes, which provide protection of the body against genetically foreign cells and substances coming exo-or endo-pathways [6,7,13,18,20]. They are also called biological "filters".…”

Section: Introductionmentioning

confidence: 99%

Structural changes of lymph nodes under high calorie diet and melatonin correction

Harapko¹,

Матешук-Вацеба²,

Holovatskyi³

2019

Rep. of Morph.

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The article presents and analyzes data from an experimental study conducted on white rats in females and males of reproductive age. The purpose of the study to study the morphometric and histological changes in the parenchyma of the lymph nodes of rats under the high-calorie diet (HCD) and with the correction of melatonin. The study was performed on 80 white rats of reproductive age. Microanatomy of the structural components of lymph nodes of white rats under physiological norms was examined in 10 intact animals. Experimental animals are divided into 5 groups. Statistical processing of digital data was performed using “Excel” software and “STATISTICA 6.0” using the parametric method. Eight weeks after HCD, there was a significant decrease in the relative area of the cortical substance in the parenchyma of lymph nodes of white rats of males and females by 10.3 % and 8.3 %, respectively, and an increase in the relative area of the medullary substance by 16.1 % and 13.2 %, respectively, greater than the intact animal group parameter. Corticomedullary index (CMI) decreased by 22.9 % and 19.0 %. After six weeks of HCD and the next six weeks of standard vivarium diet and melatonin administration, the relative area of cortical substance in the parenchyma of lymph nodes of white rats in males and females was 2.0 % and 2.9 %, respectively, greater than the parameters of the intact group of animals. Accordingly, the relative area of the medullary substance is 3.1 % and 4.6 % less than the parameters of the intact group of animals. CMI in both male and male rats was 5.1 % and 7.6 %, respectively, greater than the intact animal group parameter. Under the conditions of melatonin correction, it was found that on the histological preparations of lymph nodes the vein and artery were full-blooded. Empty hemocapillaries with thickened wall are observed. In the paracortical region, the number of high endothelial capillary venules decreases. Thus, long-term administration of melatonin improves the morphometric parameters of the parenchyma of the lymph nodes of rats, restores the morphological structure of the organ.

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Changes in the Cell Squad of Iliac Lymph Nodes of White Rats in Case of Longterm Influence of Nalbufin

Cited by 2 publications

References 5 publications

Changes in the structural organization of lymph nodes during short-term exposure to monosodium glutamate

Changes in the structural organization of lymph nodes during short-term exposure to monosodium glutamate

Structural changes of lymph nodes under high calorie diet and melatonin correction

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