Changes in the cellular component of the human innate immunity system in short-term isolation

Ponomarev, S. A.; Kutko, O.V.; Рыкова, М. П.; Kalinin, Sergei V.; Антропова, Е. Н.; Sadova, A.A.; Orlova, K.D.; Shulgina, S.M.

doi:10.1016/j.actaastro.2019.10.012

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…Nevertheless, the data obtained during Antarctica winter-over at German Antarctic Research Station Neumayer III with 10 female and 16 male subjects reveled changes in leucocyte subsets and cytokine production, however no significant differences between males and females were observed ( 51 ). In another study with 17-days isolation in a sealed chamber no sex-dependent differences in DCs and TLRs + monocytes were shown ( 52 ). In our opinion, this phenomenon could be explained by two reasons.…”

Section: Experiments With a Confinementmentioning

confidence: 99%

“…This experiment was conducted to simulate the conditions of the upcoming mission to the Moon with a landing and return to the Earth. Blood was sampled before the experiment from 6 test subjects (3 males, 3 females), on the 7 th day of confinement and on the first day of rehabilitation period ( 52 ). The experiment was unique in that the impact of confinement on such an important part of immunity as dendritic cells (DCs) was investigated.…”

Section: Experiments With a Confinementmentioning

confidence: 99%

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Immunological Aspects of Isolation and Confinement

Ponomarev¹,

Kalinin²,

Sadova³

et al. 2021

Front. Immunol.

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Beyond all doubts, the exploration of outer space is a strategically important and priority sector of the national economy, scientific and technological development of every and particular country, and of all human civilization in general. A number of stress factors, including a prolonged confinement in a limited hermetically sealed space, influence the human body in space on board the spaceship and during the orbital flight. All these factors predominantly negatively affect various functional systems of the organism, in particular, the astronaut’s immunity. These ground-based experiments allow to elucidate the effect of confinement in a limited space on both the activation of the immunity and the changes of the immune status in dynamics. Also, due to simulation of one or another emergency situation, such an approach allows the estimation of the influence of an additional psychological stress on the immunity, particularly, in the context of the reserve capacity of the immune system. A sealed chamber seems a convenient site for working out the additional techniques for crew members selection, as well as the countermeasures for negative changes in the astronauts’ immune status. In this review we attempted to collect information describing changes in human immunity during isolation experiments with different conditions including short- and long-term experiments in hermetically closed chambers with artificial environment and during Antarctic winter-over.

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Section: Experiments With a Confinementmentioning

confidence: 99%

Section: Experiments With a Confinementmentioning

confidence: 99%

Immunological Aspects of Isolation and Confinement

Ponomarev¹,

Kalinin²,

Sadova³

et al. 2021

Front. Immunol.

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“…In addition, immune differentials reported in the Mars500 isolation project in humans indicate the effects of extreme isolation on gut microbiome maintenance and immunity, a site populated by macrophages 90 . In line with this, multiple other isolation analogs, including NEEMO, Antarctica, and MOON-2015 have assessed the influence of isolation on macrophage lineage phenotypes (primarily monocytes), collectively indicating differential outcomes are observed during- and post-study collections (reviewed in 91 ). Differential outcomes may be due to the unique microbial environment present in each analog, further adding to the complexity of macrophage phenotype characterizations.…”

Section: Isolation Confinement and Extreme Environmental Stressorsmentioning

confidence: 98%

Influence of the spaceflight environment on macrophage lineages

An,

Blackwell,

Harandi

et al. 2024

npj Microgravity

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Spaceflight and terrestrial spaceflight analogs can alter immune phenotypes. Macrophages are important immune cells that bridge the innate and adaptive immune systems and participate in immunoregulatory processes of homeostasis. Furthermore, macrophages are critically involved in initiating immunity, defending against injury and infection, and are also involved in immune resolution and wound healing. Heterogeneous populations of macrophage-type cells reside in many tissues and cause a variety of tissue-specific effects through direct or indirect interactions with other physiological systems, including the nervous and endocrine systems. It is vital to understand how macrophages respond to the unique environment of space to safeguard crew members with appropriate countermeasures for future missions in low Earth orbit and beyond. This review highlights current literature on macrophage responses to spaceflight and spaceflight analogs.

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