Changes in the chemical properties and anti-oxidant activities of curcumin by microwave radiation

Jung, Yu Na; Kang, Smee; Lee, Bo Hyun; Kim, Joo Hyoun; Hong, Jungil

doi:10.1007/s10068-016-0225-1

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…BDMC was reported with many biological properties including antitumor, reduction of bone loss, hypoglycemic, and antioxidant activities . However, poor oral bioavailability resulting from the presence of massive curcuminoid glucuronide and sulfate conjugates in plasma limited the significant activities of BDMC.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, bisdemethoxycurcumin (BDMC) is one of the most abundant curcuminoids, which accounts for 0.011–0.087‰ weight of the dried rhizome . And also, it has attracted increasing interest for various biological activities including antitumor, reduction of bone loss, hypoglycemic, and antioxidant activities . For example, BDMC was considered as an effective inhibitor against aldo‐keto reductase 1B10 (a tumor marker) ( K i = 22 nM) with the efficient selectivity versus aldose reductase .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, BDMC has been successfully encapsulated in liposomes and exhibited the roles in reducing osteoclast activity and maintaining osteoblast functions . Recently, BDMC was efficiently resistant under microwave radiation .…”

Section: Introductionmentioning

confidence: 99%

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Efflux excretion of bisdemethoxycurcumin‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters

et al. 2018

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Bisdemethoxycurcumin (BDMC) was a natural curcuminoid with many bioactivities present in turmeric (Curcuma longa L.). However, the disposition mechanisms of BDMC via uridine 5 0 -diphospho-glucuronosyltransferase (UGT) metabolism still remain unclear. Therefore, we aimed to determine the potential efflux transporters for the excretion of BDMC-O-glucuronide. Herein, chemical inhibition assays (Ko143, MK571, dipyridamole, and leukotriene C4) and biological inhibition experiments including stable knocked-down of breast cancer resistance protein (BCRP), multidrug resistance-associated proteins (MRPs) transporters were both performed in a HeLa cell line stably overexpressing UGT1A1 established previously. The results indicated that Ko143 (5 and 20 μM) caused a marked reduction in excretion rate (18.4-55.6%) and elevation of intracellular BDMC-O-glucuronide (28.8-48.1%), whereas MK-571 (5 and 20 μM) resulted in a significant decrease in excretion rate (6.2-61.6%) and increase of intracellular BDMC-O-glucuronide (maximal 27.1-32.6%). Furthermore, shRNAmediated silencing of BCRP transporter led to a marked reduction in the excretion rate (21.1-36.9%) and an obvious elevation of intracellular glucuronide (24.9%). Similar results were observed when MRP1 was partially silenced. In addition, MRP3 and MRP4 silencing both displayed no obvious changes on the excretion rate and intracellular levels of glucuronide. In conclusion, chemical inhibition and gene silencing results both indicated that generated BDMC-O-glucoside were excreted primarily by the BCRP and MRP1 transporters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efflux excretion of bisdemethoxycurcumin‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters

et al. 2018

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“…Absorbance was measured at 540 nm. Oxygen radical antioxidant capacity (ORAC) assay was performed by the previous method [ 41 ]. Then, 60 μL of curcumin and PVA was mixed with 40 μL of 100 mM AAPH and 100 μL of 50 nM fluorescein sodium salt in PBS.…”

Section: Methodsmentioning

confidence: 99%

Enhancement of Solubility, Stability, Cellular Uptake, and Bioactivity of Curcumin by Polyvinyl Alcohol

Kang,

Kim,

Kim

et al. 2024

IJMS

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The biological activities and related mechanisms of curcumin, a major polyphenolic compound in turmeric, the rhizome of Curcuma longa, have been extensively investigated. Due to its poor solubility in water, the analysis of curcumin’s biological activities is limited in most aqueous experimental systems. In the present study, the effects of polyvinyl alcohol (PVA), a dietary-compatible vehicle, on the solubility, stability, cellular uptake, and bioactivities of curcumin were investigated. Curcumin solubility was improved significantly by PVA; the color intensity of curcumin aqueous solution in the presence of PVA increased concentration-dependently with its peak shift to a shorter wavelength. Improved suspension stability and photostability of curcumin in an aqueous solution were also observed in the presence of PVA, even at 62.5 μg/mL. The scavenging activities of curcumin against DPPH, ABTS, AAPH radicals, and nitric oxide were enhanced significantly in the presence of PVA. PVA at 250 μg/mL also significantly enhanced the cytotoxic activity of curcumin against both HCT 116 colon cancer and INT 407 (HeLa-derived) embryonic intestinal cells by reducing the IC50 from 16 to 11 μM and 25 to 15 μM, respectively. PVA improved the cellular uptake of curcumin in a concentration-dependent manner in INT 407 cells; it increased the cellular levels more effectively at lower curcumin treatment concentrations. The present results indicate that PVA improves the solubility and stability of curcumin, and changes in these chemical behaviors of curcumin in aqueous systems by PVA could enhance the bioavailability and pharmacological efficacy of curcumin.

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“…Exposure to microwave radiation at 500 W for 5 min degraded almost 70% of curcumin. However, the microwave heating at 500 W for 5 min caused more pronounced enhancements (46-100%) in ABTS, nitrite, and AAPH radicals scavenging activity in comparison with regular heating (Jung et al 2016). Ten min heat treatment in a pressure cooker (15 psi) decomposed curcumin into smaller compounds such as vanillin, vanillic, and ferulic acids (Suresh et al 2009).…”

mentioning

confidence: 99%

Curcumin in Food

Trifan

Aprotosoaie

2019

Handbook of Dietary Phytochemicals

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Curcumin is the major bioactive constituent of turmeric (Curcuma longa L., Zingiberaceae) rhizome. Turmeric has been used as spice and dye but also in the traditional Chinese and Indian medicine for the treatment of respiratory ailments, wounds, gastrointestinal complaints, hepatic disorders, and cardiovascular disease. Numerous studies reported curcumin as an important pleiotropic agent, with anti-inflammatory, wound healing, antioxidant, hypoglycemic, cardioprotective, neuroprotective, hepatoprotective, antimicrobial, chemopreventive, and anticancer activities. These effects have been demonstrated both in vitro and in experimental animal models, thus paving the way for various clinical trials. The latter investigated different curcumin-based formulations, including highly bioavailable formulations showing their efficacy in central nervous system, cardiovascular, gastrointestinal, liver, and metabolic diseases. Benefits in certain malignant diseases were also reported. Curcumin is marketed worldwide as dietary supplement and herbal medicine, as cosmetic product, or as food additive. Curcumin possesses a good safety profile. Chemical features of curcumin, bioactivity and mechanisms of activity, safety profile, patents, and marketed products are summarized in this chapter. As literature on the topic of curcumin has known an exponential growth, reports cited in this chapter should be considered as illustrative rather than comprehensive.

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Changes in the chemical properties and anti-oxidant activities of curcumin by microwave radiation

Cited by 10 publications

References 28 publications

Efflux excretion of bisdemethoxycurcumin‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters

Efflux excretion of bisdemethoxycurcumin‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters

Enhancement of Solubility, Stability, Cellular Uptake, and Bioactivity of Curcumin by Polyvinyl Alcohol

Curcumin in Food

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