Changes in the Content of Protein and Lipid Oxidative Modification Products in Tumor Tissue at Different Stages of Lung Cancer

Белоногов, Р. Н.; Титова, Н. М.; Лапешин, П. В.; Ivanova, Yu. R.; Shevtsova, A. O.; Pokrovskiĭ, A. V.

doi:10.1007/s10517-009-0565-4

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…Oxidative stress in cancer cells may lead to protein peroxidation, which could consume amines such as triethylamine, leading to the observed reduced concentration levels in the headspace. 30,31 On the other hand, it is reasonable to assume that the amino acids from the medium would be consumed through the metabolic activity of the cancer cells during cell growth, so that triethylamine and other amines could indeed be released as by- products into the headspace. Possibly, the different observed trends could indicate that the interplay of metabolic activity and/ or oxidative stress differs for different oncogenes.…”

Section: Discussionmentioning

confidence: 99%

Volatile fingerprints of cancer specific genetic mutations

Peled

Barash

Tisch

et al. 2013

Nanomedicine: Nanotechnology, Biology and Medicine

105

113

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We report on a new concept for profiling genetic mutations of (lung) cancer cells, based on the detection of patterns of volatile organic compounds (VOCs) emitted from cell membranes, using an array of nanomaterial-based sensors. In this in-vitro pilot study we have derived a volatile fingerprint assay for representative genetic mutations in cancer cells that are known to be associated with targeted cancer therapy. Five VOCs were associated with the studied oncogenes, using complementary chemical analysis, and were discussed in terms of possible metabolic pathways. The reported approach could lead to the development of novel methods for guiding treatments, so that patients could benefit from safer, more timely and effective interventions that improve survival and quality of life while avoiding unnecessary invasive procedures. Studying clinical samples (tissue/blood/breath) will be required as next step in order to determine whether this cell-line study can be translated into a clinically useful tool.

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Section: Discussionmentioning

confidence: 99%

Volatile fingerprints of cancer specific genetic mutations

Peled

Barash

Tisch

et al. 2013

Nanomedicine: Nanotechnology, Biology and Medicine

105

113

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“…У зв'язку з цим еритроцити можуть виступати в ролі ефективних скавенджерів АФК, що впливає на фізіологічний статус еритроцитів, зокрема регуляцію гліколізу, підтримання форми та об'єму, мембранний транспорт тощо. Встановлене в ході нашого дослідження зростання каталазної активності в еритроцитах крові можна розглядати як пристосувальну реакцію ор-ганізму у відповідь на посилення процесів ПОЛ [2].…”

Section: результати дослідження та їх обговоренняunclassified

Assessment of the intensity of lipid peroxidation and catalase activity in the blood-erythrocyte serum system in patients with laryngeal cancer

Burlaka

Verevka

Grin

2019

OTORHINOLARYNGOLOGY

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Aim: To evaluate the intensity of lipid peroxidation and the activity of catalase in patients with laryngeal cancer. Materials and Methods: Samples of blood serum and erythrocytes from 40 patients with laryngeal cancer of stages II and III and 20 healthy volunteers were investigated. Results: The level of TBA-positive products and diene conjugates in blood serum samples of stage II and III patients with laryngeal cancer was increased than that of control. In the same time catalase activity was significantly reduced. In the erythrocytes of patients in both groups the level of diene conjugates and catalase activity was higher than that of control. The level of TBA-positive products increased only in patients with III stage disease. Our results indicate the intensification of free-radical oxidation against the background of the functional stress of the antioxidant defense system in patients with laryngeal cancer, as well as the violation of the structural and functional state of erythrocyte plasma membranes, which is manifested in the activation of lipid peroxidation. This indicates about the formation of a complex of disorders, which can play a significant role in the development and deepening of the pathological process.

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“…Como resultado de estas interacciones se produce un incremento de grupos carbonilo de las cadenas laterales de los aminoácidos y un descenso de grupos tiol en el entrecruzamiento entre cadenas peptídicas o en la fragmentación de enlaces peptídicos. Esta oxidación puede dar lugar a una pérdida o modificación de la actividad biológica de las proteínas y alterar su recambio, estando asociado con un número de enfermedades relacionadas con el envejecimiento (Belonogov et al, 2009;Bulteau et al, 2006;Danielson and Andersen, 2008;Davies, 1987;Stadtman, 1992Stadtman, , 2004.…”

Section: Estrés Oxidativounclassified

Efecto de la quimioterapia antineoplásica en pacientes con cáncer colorrectal sobre biomarcadores del estrés oxidativo y del estado redox plasmático

Arteche¹,

De²

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Changes in the Content of Protein and Lipid Oxidative Modification Products in Tumor Tissue at Different Stages of Lung Cancer

Abstract: The content of LPO products (conjugated dienes, MDA) and products of oxidative modification of proteins (protein carbonyl derivatives) is reduced in tumor tissue in comparison with normal tissue and varies depending on the disease stage.

Cited by 5 publications

References 5 publications

Volatile fingerprints of cancer specific genetic mutations

Volatile fingerprints of cancer specific genetic mutations

Assessment of the intensity of lipid peroxidation and catalase activity in the blood-erythrocyte serum system in patients with laryngeal cancer

Efecto de la quimioterapia antineoplásica en pacientes con cáncer colorrectal sobre biomarcadores del estrés oxidativo y del estado redox plasmático

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