Changes in the erythrocyte membrane during magnesium deficiency

Heaton, F. W.; Tongyai, S.; Motta, Claude; Rayssiguier, Yves; Guex, Esther

doi:10.1016/s0271-5317(87)80059-3

Cited by 13 publications

(4 citation statements)

References 22 publications

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“…In a recent study using a prophylactic assay (when the rats are fed the Fe-depleted diets immediately after weaning), we have observed that rats fed Fe-deficient AIN-93-based diets had reduced bone Mg levels when compared to controls and we supposed that increased bone Mg mobilization might have occurred, allowing erythrocyte survival in Fe-deficient rats [9]. In this context, it has been demonstrated that the physical properties of the erythrocyte membrane are strongly affected by changes in cell Mg content [21]. Furthermore, it has been observed that β-thalassemic mice recover from anemia after dietary Mg supplementation for 14 days [22].…”

Section: Discussionmentioning

confidence: 97%

Hemoglobin Regeneration Efficiency in Anemic Rats: Effects on Bone Mineral Composition and Biomechanical Properties

Lobo

Gaievski

Colli

2010

Biol Trace Elem Res

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This study reports the effects of dietary iron (Fe) deficiency and recovery on bone mineral composition and strength in anemic rats submitted to a hemoglobin (Hb) repletion assay. Weanling male Wistar rats were fed a low-Fe diet (12 mg/kg) for 15 days followed by 2 weeks of Fe repletion with diets providing 35 mg Fe/kg as either ferrous sulfate (n = 8) or ferric pyrophosphate (FP; n = 12). At final day of each period (depletion and repletion), Fe-adequate animals were also euthanized. Iron status (blood Hb, Hb Fe pool, Hb regeneration efficiency), tibia mineral concentrations (Ca, Mg, Fe, Cu, and Zn) and biomechanical properties were evaluated. Iron-deficient rats had lower tibia Fe and Mg levels and bone strength when compared to controls. Yield load and resilience were positively related to tibia Mg levels (r = 0.47, P = 0.02 and r = 0.56, P = 0.004, respectively). Iron repletion did not recover tibia Mg concentrations impaired by Fe deficiency. Moreover, bone elastic properties were negatively affected by FP consumption. In conclusion, bone mineral composition and strength were affected by Fe deficiency, whereas dietary Fe source influenced tibia Mg and resistance in the period during which rats were recovering from anemia.

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Section: Discussionmentioning

confidence: 97%

Hemoglobin Regeneration Efficiency in Anemic Rats: Effects on Bone Mineral Composition and Biomechanical Properties

Lobo

Gaievski

Colli

2010

Biol Trace Elem Res

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“…Biotin (B 7 ) Anemia [56] Folate (B 9 ) Macrocytic, megaloblastic anemia [46], hemorrhage [59] Vitamin B 12 Megaloblastic anemia, microcytic and hypochromic anemia. [59,64] Vitamin A Normocytic and normochromic anemia [70,71] Vitamin C Bleeding disorder and anemia [74] Vitamin D Anemia [76] Vitamin E Anemia , Hemolysis of RBC [48,74,83] Vitamin K Bleeding disorder [84,87] Iron Microcytic and hypochromicanemia, mild thrombocytosis, chronic bleeding [29,91,93] Copper Microcytic, macrocytic and neutropenia [104], Thrombocytopenia is unusual [105] Magnesium Iron deficiency anemia [112] Selenium Anemia [115] Chromium Iron deficiency anemia [117] Calcium Iron deficiency anemia [91] Phosphorus Anemia [102] Zinc Anemia [70] (vitamin B1) [40] (Table 1).…”

Section: Hematological Manifestationsmentioning

confidence: 99%

“…Magnesium deficiency could lead to anemia, as low magnesium levels cause the red blood cell membranes to become more fragile and easily damaged. Heaton, et al revealed that anemia could develop during magnesium deficiency due to changes in the red blood cell membrane, which is the primary reason for the underlying disturbances in cellular metabolism [112].…”

Section: Magnesium Deficiencymentioning

confidence: 99%

Potential Hematology and Nutritional Complications of Bariatric Surgery

Al-Jafar¹

2018

Ann Hematol Oncol

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Bariatrics is a specialized field of medicine that deals with the etiology, prevention and management of patients with morbid obesity. Surgical and nutritional complications are two adverse effects associated with bariatric surgery. For patients in recovery, post-bariatric surgical treatment and management often involves the care of a hematologist. Long term nutritional problems may develop following bariatic surgery and should be considered by physicians, although long-term nutritional complications are often rare or just temporary. Multivitamin and iron supplementation are required as part of a patient's prophylactic postbariatric surgical management protocol; therefore, the patient's adherence to vitamin supplementation should be checked during follow up appointments. This review aims to emphasize the potential multi systemic hematological and nutritional complications of bariatric surgery. Vitamin deficiencies such as iron and vitamin B12 sometimes affect patients and therefore physicians should be aware of this in the treatment of patients with a history bariatric surgery. Inquiring about a patient's history of bariatric surgery needs to be one of the first questions to ask a patient who is presenting with vitamin deficiencies as this can cause multi system abnormalities. Many patients are lost to follow up after bariatric surgery and come back with complications. Therefore, the importance of maintaining follow up appointments should be emphasized.

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“…Mineral deficiencies also lead to anemia with the same mechanism as vitamins do. Inadequate dietary intake of Magnesium (Mg) can disrupt erythrocyte membrane, which become more fragile [13]. In contrast, high intake of Manganese (Mn) will inhibit iron absorption due to their similarity in metal transporter and transport mechanism.…”

Section: Introductionmentioning

confidence: 99%

High Prevalence Anemia in Female Adolescents with Low Intake of Vitamins and Minerals

Noviani¹,

Indarto²,

Probandari³

2018

Proceedings of the 2nd Public Health International Conference (PHICo 2017)

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Anemia is a global public health problem which female adolescents are one of the most vulnerable age groups. Anemia in female adolescents which is caused by micronutrients deficiency can influence physical growth and academic performance. Vitamin and mineral have important roles in erythrocyte formation and enhancement of iron absorption. Hence the objective of this study was to determine association between intake of vitamins, minerals and anemia in female adolescents. This study was conducted in 3 Senior and 2 Vocational High Schools in Sukoharjo Regency, Central Java. There were 120 female adolescents who participated in this study, aged 13-17 years old, and were at year X and XI. They did not have menstruation and worm infection. Anemia was determined from Hb concentration using the cyanmethemoglobin method while vitamins and minerals intake were obtained from 24-hour recall questionnaire in two alternating days. Association between vitamins and minerals intake and anemia was analyzed using chi-square test (p<0.05). Anemia was found in 37.5% female adolescents and the result of chi-square analysis indicated a positive association between folic acid (OR=1.6), Magnesium (OR=1.17) and Manganese (OR=1.97) and anemia, but it was not significant. Inadequate vitamin B 12 intake increased 1.78 times anemia risk. Higher risk of anemia was found in female adolescents with inadequate intake of Vitamin B 1 (OR=1.65) and Magnesium (OR=1.11). Whereas adequate intake of Manganese decreased 0.537 times anemia risk. Vitamins and minerals intake do not associate with anemia but it increases anemia risk in female adolescents in Sukoharjo Regency.

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Changes in the erythrocyte membrane during magnesium deficiency

Cited by 13 publications

References 22 publications

Hemoglobin Regeneration Efficiency in Anemic Rats: Effects on Bone Mineral Composition and Biomechanical Properties

Hemoglobin Regeneration Efficiency in Anemic Rats: Effects on Bone Mineral Composition and Biomechanical Properties

Potential Hematology and Nutritional Complications of Bariatric Surgery

High Prevalence Anemia in Female Adolescents with Low Intake of Vitamins and Minerals

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