Changes in the Hormonal Concentrations of Pregnant Rats and Their Fetuses Following Multiple Exposures to a Stressor During the Third Trimester

Williams, Michael T.; Davis, Harry N.; McCrea, Anne E; Long, Stacy J; Hennessy, Michael B.

doi:10.1016/s0892-0362(98)00060-9

Cited by 65 publications

(43 citation statements)

References 73 publications

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“…from GD 14 -21, which has been shown to increase levels of corticosterone and ACTH in the dam and her fetuses (Williams, Davis, McCrea, Long, & Hennessy, 1999). Unfortunately, the effects of our restraint stress protocol (a single 4-hr session occurring daily from GD 10 to 21) on the dam are at present unknown.…”

Section: Effects Of Prenatal and Postnatal Manipulationsmentioning

confidence: 98%

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

Burton¹,

Lovic²,

Fleming³

2006

Behavioral Neuroscience

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This study investigated the effects of prenatal stress and its interaction with artificial rearing (AR) on adult rat behavior. Pregnant dams underwent restraint stress from Gestational Day 10 to 21. After parturition, pups were raised by their mothers or in the AR paradigm, with or without stroking stimulation. In adulthood, rats were tested on prepulse inhibition (PPI), locomotor activity, elevated plus-maze, and spatial working memory. There were main effects and interactions of both prenatal stress and AR on activity. Additional stimulation reduced activity in nonstressed AR rats but increased activity in prenatally stressed AR rats. AR altered PPI and plus-maze behavior whereas additional stimulation partially reversed these effects. This study demonstrates that prenatal experiences can modulate the effects of postnatal treatments.

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Section: Effects Of Prenatal and Postnatal Manipulationsmentioning

confidence: 98%

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

Burton¹,

Lovic²,

Fleming³

2006

Behavioral Neuroscience

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“…Some authors suggest that PS-induced effects are mediated by high levels of maternal hormones secreted in response to stress, particularly glucocorticoids [1, 3]. In this respect it is relevant to know that there is a positive relationship between titers of plasma corticosterone in pregnant females and fetuses [5, 49]. Williams et al [49] showed that pregnant females had elevated titers of plasma corticosterone, aldosterone and corticotropin (ACTH) 15 min following termination of the stressor, and fetuses showed a pattern of changes in plasma corticosterone and aldosterone which was similar to that of pregnant females.…”

Section: Discussionmentioning

confidence: 99%

“…In this respect it is relevant to know that there is a positive relationship between titers of plasma corticosterone in pregnant females and fetuses [5, 49]. Williams et al [49] showed that pregnant females had elevated titers of plasma corticosterone, aldosterone and corticotropin (ACTH) 15 min following termination of the stressor, and fetuses showed a pattern of changes in plasma corticosterone and aldosterone which was similar to that of pregnant females. These results are consistent with a role of the HPA axis in the effects of gestational stress.…”

Section: Discussionmentioning

confidence: 99%

Naloxone Treatment Prevents Prenatal Stress Effects on Peritoneal Macrophage Activity in Mice Offspring

Fonseca

Sakai²,

Carvalho-Freitas³

et al. 2005

Neuroendocrinology

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The present study analyzed the effects of maternal stress (PS) and/or naloxone treatment on the activity of peritoneal macrophage in male and female Swiss mice offspring. Pregnant female rats received a daily footshock (0.2 mA) and/or a naloxone injection from gestational day 15 to 19. Experiments were performed on postnatal day 30 on male and female pups. The following results were obtained in male offspring: (1) PS decreased both the index and the percentage of phagocytosis, this decrement being reversed by naloxone treatment, and (2) naloxone alone decreased the percentage of phagocytosis. The following results were obtained in female offspring: (1) PS decreased spontaneous and phorbol myristate acetate-induced macrophage oxidative burst, this decrement being reversed by naloxone pretreatment, and (2) PS decreased both the index and percentage of the phagocytosis, this effect was prevented by naloxone treatment. These data are discussed focussing on a putative neuroimmune interaction involving opioidergic systems during the ontogeny of the central nervous and immune systems.

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“…Um fato contundente é o de que há uma correlação positiva entre os níveis plasmáticos de corticosterona em roedoras grávidas e seus fetos (CADET et al, 1986;WILLIAMS et al, 1999). Mais especificamente, Williams e col. demonstraram em ratas que a titulação plasmática de corticosterona, aldosterona e ACTH, 15 minutos após a exposição a um estressor, elevava-se em fêmeas gestantes e, em igual padrão, em seus fetos (WILLIAMS et al, 1999).…”

Section: Estresse E Neuroimunomodulaçãounclassified

“…Mais especificamente, Williams e col. demonstraram em ratas que a titulação plasmática de corticosterona, aldosterona e ACTH, 15 minutos após a exposição a um estressor, elevava-se em fêmeas gestantes e, em igual padrão, em seus fetos (WILLIAMS et al, 1999). Em humanos, esta premissa parece ser também válida: após a administração de glicocorticóides sintéticos à mãe, fetos entre 20 e 34 semanas apresentaram alterações de responsividade à estimulação vibro-acústica (ROTMENSCH et al, 1999).…”

Section: Estresse E Neuroimunomodulaçãounclassified

Efeitos do estresse pré-natal sobre a atividade de linfócitos de uma prole de camundongos

Kieling¹

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Changes in the Hormonal Concentrations of Pregnant Rats and Their Fetuses Following Multiple Exposures to a Stressor During the Third Trimester

Cited by 65 publications

References 73 publications

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

Naloxone Treatment Prevents Prenatal Stress Effects on Peritoneal Macrophage Activity in Mice Offspring

Efeitos do estresse pré-natal sobre a atividade de linfócitos de uma prole de camundongos

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