Changes in the level of fetoplacental complex hormones in pregnant women with miscarriage

Lisova, K. M.; Kalinovska, I. V.; Pryimak, S. H.; Токар, П.; Varlas, Valentin

doi:10.25122/jml-2021-0089

Cited by 7 publications

(7 citation statements)

References 29 publications

(29 reference statements)

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“…While in case of viable group 75% of the subjects had levels above 71pg/ml. Many studies have reported the significance of high serum estradiol levels in viable pregnancy 10,11,12 . Aksoy et al reported a cut-off value of 350pg/ml of serum estradiol during first trimester is 80% sensitive and 70% specific for predicting viable pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Serum Estradiol levels during First Trimester of Pregnancy

Khalid¹,

Gill²,

Nazir³

et al. 2022

PJMHS

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Aim: To investigate serum estradiol levels during first trimester. Methods: It was a descriptive, cross-sectional study, conducted on pregnant women between 18 to 35 years of age presenting during first trimester in obstetric unit of a tertiary care hospital in Lahore, Pakistan. Ultrasonography was done to confirm the viability of fetus. 53 women with nonviable pregnancy were included Group 1 and 28 women with viable fetus and no complication were included in Group 2. Those having any systemic illness or history of estrogen intake were excluded. Using aseptic measures, venous blood samples were taken, and serum was separated. Serum estradiol levels were measured by using immunoenzymometric assay (EIA). Median serum Estradiol levels were compared. Receiver operative characteristics (ROC) curve was plotted. Results: Median serum estradiol levels of women with viable pregnancy 150.49 ng/mL (71.01-393.75) were significantly higher than abortion group 9.96ng/mL (2.87-37.7). A cut off value 47.9ng/ml of serum estradiol is 82% sensitive and 81% specific for a viable pregnancy. Conclusion: Optimal serum estradiol levels are necessary for viability of pregnancy. Keywords: Estradiol, pregnancy, abortion, first trimester, early pregnancy failure.

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Section: Discussionmentioning

confidence: 99%

Serum Estradiol levels during First Trimester of Pregnancy

Khalid¹,

Gill²,

Nazir³

et al. 2022

PJMHS

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“…Ехографічна оцінка даної екстраембріональної стуктури проводилася з 7 тижнів вагітності, від початку візуалізації гладкого і ворсинчатого хоріону. При ультразвуковому дослідженні в І триместрі неускладненої вагітності хоріон відрізнявся гомогенною дрібнозернистою структурою середньої ехогенності з чітким рівним внутрішнім контуром плодової поверхні і розмитим з материнської сторони [12]. При цьому за період динамічного спостереження відзначений постійний ріст товщини хоріону, у середньому на 1,0±0,3 мм за тиждень.…”

Section: результати дослідження та їх обговоренняunclassified

Ultrasound Characteristics of the Development of the Fetoplacentary Complex in Premier Pregnancy

Kalinovsk¹,

Lisova²,

Kozar³

2022

Neonatol. hìr. perinat. med.

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The article is devoted to the study of ultrasound changes in the fetoplacental complex in the early gestational period in pregnant womenwith miscarriage. Placental insufficiency (PI) is a syndrome caused by morpho-functional changes and is the result of a complex responseof the fetus and placenta to various pathological conditions of the maternal body [1]. It is based on disorders of compensatory-adaptivemechanisms of the fetoplacental complex (FPC) at the molecular, cellular and tissue levels. Ultrasound fetometry and placentometry are very important methods for diagnosing the state of the fetoplacental complex and can be used from the early term. Many researchers identify a number of prognostically unfavourable ultrasound markers: low chorion attachment, especially with the appearance of areas of detachment, discrepancy between the size of the foetus and gestational age, lack of clear visualization of the embryo, especially its heartbeat. In pregnant women with a history of miscarriage it is important to identify early signs of placental dysfunction from the firsttrimester onwards and to provide adequate correction for this condition. For this situation it is important to create appropriate conditions for the development and growth of the placenta and its adequate functioning. Significant fetal abnormalities occur as early as the first trimester and have a significant impact on the further process of ontogenesis.Aims and objectives of the study. To assess the normal parameters of embryonic and extraembryonic formation and to evaluate theparticular features of the formation and development of the fetoplacental system during pregnancy in women with a history of miscarriage.Materials and Methods. We erformed a comprehensive ultrasonographic examination of 25 somatically healthy women with aphysiological gestational process (control group) between 5 - 40 weeks’ gestation and 25 pregnant women with a history of miscarriage (study group). The SONOACE 8800 GAI MT with a 3.5 to 7.5 MHz convex transducer was used in the study. The data were statistically processed using standard methods of mathematical analysis with the use of Student’s and Fisher’s criteria, standard and specialized computer programs. Paired correlation indices were used to study the nature and degree of correlation between different parameters. The scientific research was positively evaluated by the Bioethics Commission of the Bukovinian State Medical University (Protocol No. 4 of 6.12.2021).Results and their discussion. In the transvaginal examination, uncomplicated pregnancy is characterized by the mandatoryvisualization of the embryo in the fetal cavity with a diameter of 14 mm or more, corresponding to 6 weeks' gestation. From the time of embryo identification in our study, we measured the coccygeal-parietal size (CPS) and compared its values with gestational age. It was found that in 22 (88.0%) cases the embryo size corresponded to the calculated gestational age and the mean inner diameter of the fetal egg. In severe clinical manifestations of threatened miscarriage the most sensitive echographic sign was a decrease in the volume of the foetus, which is a marker of further adverse pregnancy course and outcome. However, when there was an isolated increase in myometrial tone in the absence of clinical manifestations of threatened abortion, there was predominantly an isolated reduction in amniotic cavityvolume, easily corrected by the administration of conventional antispasmodic therapy.The ultrasonic criteria for alterations in pregnancy were developed, including delay in embryo CTR by 2 weeks or more on ultrasound examination up to 9 weeks' gestation; bradycardia at 90 bpm or less up to 8-12 weeks' gestation; chorionic detachment withretrochorial hematoma formation (over 25 ml); tachycardia at over 200 bpm with clinical manifestations of spontaneous miscarriage; marked progressive decrease of amniotic cavity volume; severe polyhydramnios with a thick echopositive suspension in the amniotic cavity. The risk of spontaneous miscarriage and formation of placental insufficiency increases with the simultaneous detection of 2 or more echographic markers.Conclusions. On the basis of the above, it is possible to conclude on the need to conduct an ultrasound examination with an assessment of the echographic parameters of the formation and development of the embryo and extraembryonic structures in the first trimester in pregnant women with a history of miscarriage and a risk of developing placental insufficiency in the history in order toidentify markers of a complicated course of gestation and the and the subsequent choice of rational tactics of pregnancy management.

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“…However, the mechanism of their occurrence is not fully understood, which leads to low awareness of diagnostic research methods and insufficient effectiveness of many existing treatments (Dobrohotova YU.E. et al, 2016: Lisova K.M., 2021.…”

Section: Introductionmentioning

confidence: 99%

Features of Reproductive Function in Women With Miscarriages

Sharhorodska

Melenchuk

2022

SJPU

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The aim of the study was to analyse the reproductive function of women with miscarriages among the population of Lviv region. The data of the results of medical and genetic counseling of 120 women with miscarriages who visited the medical and genetic center and the “Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine” were analyzed. The obtained indicators were compared with similar parameters of the control group: 80 healthy women who asked for family planning consultation. A group of women with miscarriage was formed to study the features of menstrual function, somatic, reproductive and gynecological history in comparison with similar indicators in healthy women. It was found that the majority of women (47 (39.2%) with miscarriages were aged 31–15 years and 74 (61.6%) of women by social status were employees. 52 (48.0%) women of the main group had the onset of menarche significantly later – after 15 years old, in 25 (20.8%) of them the duration of the menstrual cycle was 28–85 days and in 11 (9.1%) – 35–55 days (p < 0.05). Women with miscarriages were significantly more likely to have a complicated somatic history and these are 86 (71.7%), mainly due to pathology of the cardiovascular system – 27 (22.5%), against 43 (53.75%) and 9 (11, 2%) (p <0.05), respectively. All of them 120 (100.0%) had significantly more frequent complications of reproductive and gynecological history due to miscarriages and stillbirths. In the control group this figure was 11 (13.7%) and 19 (23.8%) respectively (p<0.05).

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Changes in the level of fetoplacental complex hormones in pregnant women with miscarriage

Cited by 7 publications

References 29 publications

Serum Estradiol levels during First Trimester of Pregnancy

Serum Estradiol levels during First Trimester of Pregnancy

Ultrasound Characteristics of the Development of the Fetoplacentary Complex in Premier Pregnancy

Features of Reproductive Function in Women With Miscarriages

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