Changes in the Liver Fat of the Pregnant Sheep at Different Levels of Nutrition and during Starvation

Nl, Ferguson

doi:10.1079/bjn19540039

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…Liver. The general agreement of the histological assessment of fat with that found by chemical analysis was noted by Ferguson (1954) on the basis of preliminary information available when he was writing his paper. The detailed observations recorded here confirm the earlier impressions, but a close examination of the results in Tables I and z reveals certain inconsistencies.…”

Section: Discussionmentioning

confidence: 58%

“…It must be emphasized, however, that the histological picture presented in the liver specimens showed striking similarities to those published by Best and his co-workers. Ferguson (1954) reported a slight decrease of fat from 8.8 to 6.1 yo from the beginning to the 100th day of pregnancy. This difference was not detected histologically, possibly because of the smallness of change; the figures given by Ferguson represent the average for the groups, and it is encouraging to find that the two animals killed at IOO days, in which the increase in fat could just be detected in the sections, had the highest percentage of fat (Ferguson, 1953) of all those in the group.…”

Section: Discussionmentioning

confidence: 97%

“…The results are shown in Tables I and 2. Values from Ferguson (1954) are given and the histological assessment described here is added. In Table I the assessment represents an 'average' for each group, and in Table 2, in which the results from individual animals are given, the form in which the fat is present is indicated.…”

Section: Livermentioning

confidence: 99%

“…Table 3 of Ferguson (1954). Table 4 of Ferguson (1954). t For explanation of symbols see Table I. Diffuse fatty droplets were observed in some proximal tubules of the low-plane, unstarved group and globules of fat were observed in the cells of some ascending limbs of Henle as well as in the lumen of these tubules.…”

Section: Livermentioning

confidence: 99%

“…A summary of the experimental procedure used by Ferguson (1954) is given here; for a detailed account the reader is referred to the original paper. The forty-four ewes were kept on an old pasture and received no supplementary food for 5 weeks before the beginning of the experiment.…”

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Fat in Liver and Kidneys of Pregnant Sheep at Different Levels of Nutrition and during Starvation

De¹

1955

Br J Nutr

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The amount of fat in the liver of pregnant sheep, in animals both on adequate and on poor diets, has been a subject of disagreement amongst workers for many years. The literature is reviewed by Ferguson (I954), who published the results of an experiment in which he kept forty-four ewes under controlled conditions. He studied the effect during pregnancy of two planes of nutrition, one high and the other low, on the liver fat which was determined gravimetrically as the total ether-soluble fraction. At the time of slaughter of these animals, portions of appropriate size were taken from the liver and kidneys and placed in 5 yo form01 saline. This paper reports the results of a histological examination of these specimens and thus is a study complementary to Ferguson's work.A summary of the experimental procedure used by Ferguson (1954) is given here; for a detailed account the reader is referred to the original paper. The forty-four ewes were kept on an old pasture and received no supplementary food for 5 weeks before the beginning of the experiment. They were then penned singly indoors except for 5-6 h each day when they were allowed exercise in an uncovered yard. They were fed singly in their pens. The ewes were slaughtered after varying periods, five being killed at random as non-pregnant controls on the day of service of the remainder. For the first IOO days of pregnancy an adequate diet was provided, described as 'high-plane'; from the 95th to the 1oznd day of pregnancy a further six were killed and a random division was made of the rest of the animals into two groups, fifteen in one and eighteen in the other. The first group was kept on the high-plane diet and the second on a lowplane diet which was insufficient for the requirements of the pregnant ewe. The animals from both these groups were killed at varying intervals from the 119th to the 1 4 t h day. From the 138th day of pregnancy onwards food, but not water, was https://www.cambridge.org/core/terms. https://doi

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 97%

Section: Livermentioning

confidence: 99%

Section: Livermentioning

confidence: 99%

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confidence: 99%

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