Changes in the mucus barrier of the rat during 5-fluorouracil-induced gastrointestinal mucositis

Saegusa, Yoichi; Ichikawa, Takafumi; Iwai, Tomohisa; Goso, Yukinobu; Okayasu, Isao; Ikezawa, Tomoaki; Shikama, Nobuaki; Saigenji, Katsunori; Ishihara, Kazuhíko

doi:10.1080/00365520701579662

Cited by 33 publications

(21 citation statements)

References 24 publications

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“…Mucin is involved in protection of the mucosa and the maintenance of normal intestinal flora . Cavitated goblet cells (goblet cells which have released mucins through exocytosis) and Muc4 expression increased in the jejunum of rats treated with irinotecan or 5‐fluorouracil (5‐FU), but mucin levels decreased in the rat jejunum and colon after 5‐FU treatment . The increased number of goblet cells reported here may be related to an overproduction to protect the mucosa .…”

Section: Discussionmentioning

confidence: 71%

Alterations in the small intestinal wall and motor function after repeated cisplatin in rat

Uranga

García-Martínez

García-Jiménez

et al. 2017

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 71%

Alterations in the small intestinal wall and motor function after repeated cisplatin in rat

Uranga

García-Martínez

García-Jiménez

et al. 2017

Neurogastroenterology Motil

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“…Mucins have been shown to be associated with mucositis [22,23,54,55,56]. Dark Agouti (DA) rat models of mucositis have been used to determine a significant association with mucin secretion and expression [22,23].…”

Section: Effects Of Chemotherapymentioning

confidence: 99%

“…Furthermore, a Wistar rat model of 5-FU-induced mucositis (5 × 50 mg/kg) caused a significant ( p < 0.05) decrease in mucin levels compared to controls in the jejunum and colon [55], suggesting mucin expression was decreased. Mucin expression has also been shown to be significantly ( p < 0.05) decreased in a Wag/Rij rat model of methotrexate (MTX) induced mucositis (2 × 10 mg/kg), with Muc 2 expression decreased significantly from 72 h to 44 h following MTX administration [56].…”

Section: Effects Of Chemotherapymentioning

confidence: 99%

Interaction between Host Cells and Microbes in Chemotherapy-Induced Mucositis

Stringer

2013

Nutrients

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Cancer patients receiving chemotherapy often develop mucositis as a direct result of their treatment. Recently, the intestinal microbiota has attracted significant attention in the investigation of the pathobiology of mucositis, with a number of studies investigating the effects of chemotherapeutic agents on the microbiota. With significant effects on the intestinal microbiota occurring following the administration of chemotherapy, there is now interest surrounding the downstream pathological effects that may be associated with the altered intestinal ecology. This review seeks to identify links between signalling pathways previously demonstrated to have a role in the development of mucositis, and the altered intestinal microbiota.

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“…Our previous studies showed quantitative and qualitative changes in GI mucin in normal and diseased animals, as well as in humans, and demonstrated the importance of mucin in the GI mucosal barrier [15–18]. We have also established several monoclonal antibodies (mAbs) that react with mucin synthesized and secreted by specific mucus-producing cells of the rat GI mucosa [18–20]. …”

Section: Introductionmentioning

confidence: 99%

Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats

Yamamoto

Ishihara

Takeda

et al. 2013

BioMed Research International

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Aim. Gastrointestinal mucositis is a frequent complication of antineoplastic chemotherapy, but the effects of chemotherapy on mucosal defense mechanisms remain poorly understood. We studied the effects of cisplatin on mucin, one of the principal defense factors of the gastrointestinal mucosa, and evaluated the efficacy of two different types of H2-receptor antagonists against cisplatin-induced mucositis. Methods. Cisplatin (6 mg/kg) was administered intravenously to rats (day 0). The rats were sacrificed 1, 3, 7, and 11 days after treatment, and their stomach, jejunum, ileum, and colon were removed. Immunoreactivity of the mucosa was compared with the use of anti-mucin monoclonal antibody. To evaluate the efficacy of H2-receptor antagonists, either famotidine (3 mg/kg) or lafutidine (30 mg/kg) was given orally once daily on days 0, 1, and 2. Histological and biochemical findings were compared among the groups to assess effects on cisplatin-induced injury. Results. Cisplatin significantly altered the immunoreactivity and content of mucin in the small intestinal mucosa, especially in the ileum. Lafutidine protected against cisplatin-induced mucosal injury and attenuated decreased mucin accumulation. Conclusion. Cisplatin appears to alter the mucus barrier function in the intestinal mucosa. Lafutidine might effectively prevent chemotherapy-induced mucositis by activating intestinal mucus cells.

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Changes in the mucus barrier of the rat during 5-fluorouracil-induced gastrointestinal mucositis

Abstract: The activation of mucus cells in the jejunum, if appropriately manipulated, could lead to more effective prevention of CT-induced GI mucositis.

Cited by 33 publications

References 24 publications

Alterations in the small intestinal wall and motor function after repeated cisplatin in rat

Alterations in the small intestinal wall and motor function after repeated cisplatin in rat

Interaction between Host Cells and Microbes in Chemotherapy-Induced Mucositis

Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats

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