2006
DOI: 10.1271/bbb.70.890
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Changes in the Mutagenic and Estrogenic Activities of 17β-Estradiol after Treatment with Nitrite

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Cited by 6 publications
(9 citation statements)
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“…The potential of applying estrogen nitration in wastewater treatment depends on whether estrogenic activity is reduced after nitration. Reduced estrogenic activity following E2 nitration has been reported for 2-nitro-E2, but not for 4-nitro-E2 (Masuda et al, 2006;Palomino et al, 1996;Pezzella et al, 2004). However, Wang et al (2007) also reported that estrogenic activity of nitro-E2 was reduced when compared with E2, when evaluating a mixture of 2-nitro-and 4-nitro-E2.…”
Section: Resultsmentioning
confidence: 99%
“…The potential of applying estrogen nitration in wastewater treatment depends on whether estrogenic activity is reduced after nitration. Reduced estrogenic activity following E2 nitration has been reported for 2-nitro-E2, but not for 4-nitro-E2 (Masuda et al, 2006;Palomino et al, 1996;Pezzella et al, 2004). However, Wang et al (2007) also reported that estrogenic activity of nitro-E2 was reduced when compared with E2, when evaluating a mixture of 2-nitro-and 4-nitro-E2.…”
Section: Resultsmentioning
confidence: 99%
“…The reaction mixture of bisphenol A or 17-estradiol and nitrite, which showed mutagenic activities, has previously been demonstrated to generate radicals by ESR. 13,14) We therefore tested the radical generation from the reaction mixture of nitrite and genistein by ESR in this study. Figure 3 shows that the radical intensity of nitrite-treated genistein increased with time after adding DMPO.…”
Section: Resultsmentioning
confidence: 99%
“…12) An earlier study has also demonstrated that bisphenol A and 17-estradiol showed mutagenic activities after a nitrite treatment under acidic conditions. 13,14) Isoflavones, which are known as plant polyphenols, might therefore show mutagenicity after the reaction with nitrite under acidic conditions. The present study examines the mutagenic activities of genistein with the Ames test and micronucleus test after a nitrite treatment under acidic conditions by using ICR male mice.…”
mentioning
confidence: 99%
“…Reduced estrogenic activity following E2 nitration has been reported for 2-nitro-E2, but not for 4-nitro-E2 (Palomino et al 1996;Pezzella et al 2004;Masuda et al 2006). However, Wang et al(2007) also reported that estrogenic activity of nitro-E2 was reduced when compared to E2, when evaluating a mixture of 2-nitro-and 4-nitro-E2.…”
Section: Potential Applications Of Estrogen Nitration In Wastewater Tmentioning
confidence: 97%
“…The estrogenic activity of nitro-EE2 has not been reported. The possibility of increased mutagenic or carcinogenic properties of nitrated estrogen compounds also should be considered (Masuda et al 2006), although the relevance at ng/L concentrations is questionable.…”
Section: Potential Applications Of Estrogen Nitration In Wastewater Tmentioning
confidence: 99%