Changes in the number of dendritic spines in the medial preoptic area during a premature long-term social isolation in rats

Sánchez-Toscano, Fernando; Sánchez, María Jesús Torquemada; Garzón, Javier

doi:10.1016/0304-3940(91)90178-v

Cited by 20 publications

(6 citation statements)

References 11 publications

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“…Chronic exposure to an impoverished environment (started after weaning) induces an increase of asymmetric synapses in the motor cortex of cats (spine and shaft) (55) and an increase of mean synaptic density in rats (56). In contrast, increased synaptic densities were found after exposure to enriched environmental conditions, e.g., in the occipital cortex (5,(56)(57)(58), medial preoptic area (59), and striatum (60, 61) of rats.…”

Section: Discussionmentioning

confidence: 75%

Juvenile emotional experience alters synaptic composition in the rodent cortex, hippocampus, and lateral amygdala

Poeggel

Helmeke

Abraham

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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A quantitative anatomical study in the rodent anterior cingulate and somatosensory cortex, hippocampus, and lateral amygdala revealed region-, cell-, and dendrite-specific changes of spine densities in 3-week-old Octodon degus after repeated parental separation. In parentally separated animals significantly higher spine densities were found on the apical and basal dendrites of the cingulate cortex (up to 143% on apical and 138% on basal dendrite). Branching order analysis revealed that this effect is seen on all segments of the apical dendrite, whereas on the basal dendrites significantly higher spine densities were seen only on the outer branches (third to fifth dendritic segments). Increased spine densities were also observed on the hippocampal CA1 pyramidal neurons (up to 109% on the distal apical segments and up to 106% on the basal segment) compared with the control group. In contrast, significantly reduced spine densities were observed on the granule cell dendrites in the dentate gyrus (down to 92%) and on the apical dendrites in the medial nucleus of the amygdala (down to 95%). No significant changes of spine densities were seen in the somatosensory cortex (except for an increase in the proximal apical segments) and in the lateral nucleus of the dorsal amygdala (except for an increase in the proximal basal dendritic segments). These results demonstrate that repeated stressful emotional experience alters the balance of presumably excitatory synaptic inputs of pyramidal neurons in the limbic system. Such experience-induced modulations of limbic circuits may determine psychosocial and cognitive capacities during later life.limbic system ͉ stress ͉ dendritic spines ͉ parental separation ͉ cingulate cortex

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Section: Discussionmentioning

confidence: 75%

Juvenile emotional experience alters synaptic composition in the rodent cortex, hippocampus, and lateral amygdala

Poeggel

Helmeke

Abraham

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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“…Rats which experienced maternal separation between postnatal days 3-5 ended up with fewer dendritic spines in the anterior cingulate cortex, as opposed to the animals which experienced the same amount of maternal separation at days 14-16 (Bock et al). Chronic social isolation after weaning resulted in reduced numbers of perforated synapses and smaller synaptic contact zones in the dorso-medial amygdala (Ichikawa, Mastuoka, & Mori, 1993) of rats, whereas an increased density of dendritic spines was found in the preoptic region of deprived rats (Sanches-Tosccano, Sanchez, & Garzon, 1991). Furthermore, rats which were exposed to stress in utero during the last week of gestation (i.e., the pregnant dams were exposed to different types of stress) showed changes in the density of dendritic spines in the anterior cingulate and orbitofrontal cortex compared to control animals (Murmu et al, 2006).…”

Section: Impact Of Early Emotional Experience On Synaptic Reorganizatmentioning

confidence: 93%

The international society for developmental psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development

Sullivan

Wilson

Feldon

et al. 2006

Developmental Psychobiology

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Decades of research in the area of developmental psychobiology have shown that early life experience alters behavioral and brain development, which canalizes development to suit different environments. Recent methodological advances have begun to identify the mechanisms by which early life experiences cause these diverse adult outcomes. Here we present four different research programs that demonstrate the intricacies of early environmental influences on behavioral and brain development in both pathological and normal development. First, an animal model of schizophrenia is presented that suggests prenatal immune stimulation influences the postpubertal emergence of psychosis-related behavior in mice. Second, we describe a research program on infant rats that demonstrates how early odor learning has unique characteristics due to the unique functioning of the infant limbic system. Third, we present work on the rodent Octodon degus, which shows that early paternal and/or maternal deprivation alters development of limbic system synaptic density that corresponds to heightened emotionality. Fourth, a juvenile model of stress is presented that suggests this developmental period is important in determining adulthood emotional well being. The approach of each research program is strikingly different, yet all succeed in delineating a specific aspect of early development and its effects on infant and adult outcome that expands our understanding of the developmental impact of infant experiences on emotional and limbic system development. Together, these research programs suggest that the developing organism's developmental trajectory is influenced by environmental factors beginning in the fetus and extending through adolescence, although the specific timing and nature of the environmental influence has unique impact on adult mental health.

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“…Other brain regions may undergo excessive proliferation (or suppressed pruning) of synaptic contacts. For instance, socially deprived domestic chicks, which were raised in complete social deprivation (‘Kaspar Hauser’ conditions), and rodents, which were repeatedly separated from their family, displayed elevated synaptic densities in the prefronal cortex including the anterior cingulate cortex 16,18 and the preoptic region 19 . It is important to note that the developmental time window, i.e.…”

Section: Perinatal Emotional Experience Drives Synaptic Reorganizatiomentioning

confidence: 99%

“…For instance, socially deprived domestic chicks, which were raised in complete social deprivation ('Kaspar Hauser' conditions), and rodents, which were repeatedly separated from their family, displayed elevated synaptic densities in the prefronal cortex including the anterior cingulate cortex 16,18 and the preoptic region. 19 It is important to note that the developmental time window, i.e. the maturity of the brain during deprivation, as well as the duration of the deprivation, essentially determines the magnitude and direction of the synaptic changes.…”

Section: Perinatal Emotional Experience Drives Synaptic Reorganizatiomentioning

confidence: 99%

The experience‐dependent maturation of prefronto‐limbic circuits and the origin of developmental psychopathology: implications for the pathogenesis and therapy of behavioural disorders

Braun

Bock

2011

Develop Med Child Neuro

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The maturation of prefronto‐limbic neuronal pathways that mediate essential affective and social regulatory functions is experience dependent. Immediately after birth the infant’s affective experiences, especially those embedded in the relationship with the primary caregiver, trigger the reorganization and adaptive fine‐tuning of synaptic circuits. Research in humans and in animal models supports the hypothesis that socio‐emotional deprivation and emotional trauma during early childhood may leave ‘scars’ in prefronto‐limbic function, brain regions that are essential for emotional behaviour, learning, and memory. The focus of this review is to point out that mechanisms involved in structuring and optimizing neural circuits during brain development might also be used in moulding personality and behaviour during psychotherapy in the adult brain.

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Changes in the number of dendritic spines in the medial preoptic area during a premature long-term social isolation in rats

Cited by 20 publications

References 11 publications

Juvenile emotional experience alters synaptic composition in the rodent cortex, hippocampus, and lateral amygdala

Juvenile emotional experience alters synaptic composition in the rodent cortex, hippocampus, and lateral amygdala

The international society for developmental psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development

The experience‐dependent maturation of prefronto‐limbic circuits and the origin of developmental psychopathology: implications for the pathogenesis and therapy of behavioural disorders

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