Changes in the Periodontium and Pulp in ISIAH Rats Caused by Stress Exposures in Different Modes

Periodontal Destruction and Regeneration in Experimental Models: Combined Research Approaches

“…Material and methods. The rat models, used in the reviewed publications were: ligature-induced [5,13,[15][16][17][18][19], streptozotocin-induced [2,3,20,21] and immune complexes-induced [22] experimental periodontitis; 3-wall periodontal defect in Wistar rats [9,14],osteoporotic rats periodontal fenestration defect model [4], apical periodontitis, induced in Wistar rats by pulp exposure to oral cavity [23], altered functional loading model with use of a hard and soft diet and the posterior bite-blocks in rats [24], as well as rats stress exposures in different modes [25], experimental rat model of surgically created chronic acid reflux esophagitis [26]. The combined bilayered compartmentalized system was used to promote the regeneration of alveolar bone in Wistar rats [14].…”

“…Acute stress was associated with a significant increase in the area of periodontal and pulp vessels, a decrease in the area of connective tissue of these components, and an increase in the thickness of the vascular endothelium. Chronic stress in these animals induced an increase in the thickness of the endothelial layer of the periodontal and pulp vessels, fibromatosis, and a sharp decrease in the level of odontoblasts [25]. Association between surgically created gastric acid reflux and oro-pharyngeal diseases has been elucidated by Shimazu R. et al (2018).…”