1986
DOI: 10.1016/0030-4220(86)90007-1
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Changes in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancer

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Cited by 68 publications
(37 citation statements)
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“…Besides, studies show that systemic agents, such as pilocarpine, are more effective when used during radiotherapy. 34,40 This has also been recently showed for betanechol, when the drug used concomitantly with radiotherapy is able to increase salivary flow at rest, right after the end of the radiotherapy treatment, besides decreasing the subjective complaint of dry mouth. 41 …”
Section: Xerostomiamentioning
confidence: 69%
“…Besides, studies show that systemic agents, such as pilocarpine, are more effective when used during radiotherapy. 34,40 This has also been recently showed for betanechol, when the drug used concomitantly with radiotherapy is able to increase salivary flow at rest, right after the end of the radiotherapy treatment, besides decreasing the subjective complaint of dry mouth. 41 …”
Section: Xerostomiamentioning
confidence: 69%
“…It is unlikely that albumin has anything to do with the caries process per se; rather this finding is a consequence of leakage of serum components (glucose, albumin) into saliva of diabetics. Albumin is normally present in saliva only in trace amounts [Oppenheim, 1970], but is increased in salivary gland disorders [Makkonen et al, 1986;Vesterinen et al, 2007], and thus parallels the elevated glucose in saliva.…”
Section: Discussionmentioning
confidence: 99%
“…They found signifi cantly reduced fraction of acidic proline-rich proteins compared with non-irradiated healthy subjects. On the other hand, Makkonen et al (1986) analyzed the radiation-induced changes in the fl ow rate and protein composition of stimulated whole saliva in eleven patients treated for malignant conditions of the head and neck. They observed unusually high salivary concentrations of albumin, lactoferrin, lysozyme, salivary peroxidase, myeloperoxidase, and total protein during the therapy, but most values slowly returned to pretreatment levels after cessation of radiation.…”
Section: Discussionmentioning
confidence: 99%