Dental Caries Increments and Related Factors in Children with Type 1 Diabetes Mellitus

Abstract

The aim of this study was to analyse possible associations between caries increments and selected caries determinants in children with type 1 diabetes mellitus and their age- and sex-matched non-diabetic controls, over 2 years. A total of 63 (10–15 years old) diabetic and non-diabetic pairs were examined for dental caries, oral hygiene and salivary factors. Salivary flow rates, buffer effect, concentrations of mutans streptococci, lactobacilli, yeasts, total IgA and IgG, protein, albumin, amylase and glucose were analysed. Means of 2-year decayed/missing/filled surface (DMFS) increments were similar in diabetics and their controls. Over the study period, both unstimulated and stimulated salivary flow rates remained significantly lower in diabetic children compared to controls. No differences were observed in the counts of lactobacilli, mutans streptococci or yeast growth during follow-up, whereas salivary IgA, protein and glucose concentrations were higher in diabetics than in controls throughout the 2-year period. Multivariable linear regression analysis showed that children with higher 2-year DMFS increments were older at baseline and had higher salivary glucose concentrations than children with lower 2-year DMFS increments. Likewise, higher 2-year DMFS increments in diabetics versus controls were associated with greater increments in salivary glucose concentrations in diabetics. Higher increments in active caries lesions in diabetics versus controls were associated with greater increments of dental plaque and greater increments of salivary albumin. Our results suggest that, in addition to dental plaque as a common caries risk factor, diabetes-induced changes in salivary glucose and albumin concentrations are indicative of caries development among diabetics.

Impact of Hyperglycemia on Xerostomia and Salivary Composition and Flow Rate of Adolescents with Type 1 Diabetes Mellitus

“…The latter value (Siudikiene et al, 2006) is similar to the average SSFR in well-controlled adolescents in the present study (DM1-A group, 1.140 mL/min, Table 2). The average SSFR value was significantly different between DM1 group (0.932 mL/min) and control group (1.224 mL/min), which is in consonance with previous studies with adolescents with DM1 (Siudikiene et al, 2006(Siudikiene et al, , 2008. In the present study, hyperglycemia was associated to a reduction in salivary flow (Table 2).…”

“…Furthermore, xerostomia was shown to have a negative impact on the quality of life of adolescents with DM1 (Busato et al, 2009). The relationship among DM1, salivary composition and xerostomia has been widely investigated (Swanljung et al, 1992;Moore et al, 2001;López et al, 2003;Siudikiene et al, 2006;Siudikiene et al, 2008;Orbak et al, 2008). It has been found that most DM1 patients have salivary dysfunction as well as differences in biochemical salivary composition compared with healthy subjects (Swanljung et al, 1992;Moore et al, 2001;López et al, 2003;Siudikiene et al, 2006;Siudikiene et al, 2008;Orbak et al, 2008).…”

Caries e índice de higiene oral en niños con diabetes mellitus tipo 1

“…Si bien no se observó una asociación estadística entre el tipo de dieta y la presencia de caries, los resultados no son concluyentes y pueden deberse a la baja proporción de pacientes DM1 con dieta cariogénica tipo moderada. Sin embargo, el riesgo de caries en pacientes diabéti-cos se asocia principalmente a los cambios en la composición y flujo de la saliva (aumento en las concentraciones de glucosa y albumina), un pobre control de la placa bacteriana 26,27 y un mal control metabólico de la diabetes 28 tal como se presenta en la población seleccionada en este reporte.…”

Diabète de type I chez l’enfant : gestion clinique des pathologies bucco-dentaires

“…La forte prévalence de la carie chez les diabétiques peut aussi s'expliquer par un taux de glucose plus élevé dans leur salive [2]. Nos résultats corroborent ceux de Siudikiene et al [21,23,24]. Les enfants Tableau VI.…”