Changes in the Rheologic Properties of Blood as Induced by Sodium/Meglumine Ioxaglate Compared with Sodium/Meglumine Diatrizoate and Metrizamide

Stäubli, M; Braunschweig, J; Tillmann, U

doi:10.1177/028418518202300111

Cited by 11 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings agree well with preliminary reports by STRICKLAND et al (29) who also found that low-shear viscosity decreased and high-shear viscosity increased with increasing CM concentration. STÄUBLI et al (27), who found an increase in low-shear viscosity, used a lowest shear rate of 5.8/s, which may be one explanation for the discrepancy between our results.…”

Section: Discussioncontrasting

confidence: 82%

“…It is generally accepted that at high shear rates, the shearing deformation of the erythrocytes is Accepted for publication 29 February 1992. the main determinant of whole-blood apparent viscosity, whereas at low shear rates, where viscosity is considerably higher, aggregation is the most important factor (9). STÄUBLI et al (27) have found that the viscosity of whole blood is increased, at both low and high shear rates, by mixing it with CM; rather less, however, with ioxaglate than with metrizamide and diatrizoate. SCHMID-SCHÖNBEIN et al (26) compared iopamidol and diatrizoate and found the greatest effects with the latter substance.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Viscosity of Some Contemporary Contrast Media before and after Mixing with Whole Blood

Smedby¹

1992

Acta Radiol

View full text Add to dashboard Cite

The viscosity of 7 contrast media was measured using a rotational viscometer. When solutions with similar iodine concentrations were compared, the highest viscosities were found for the nonionic dimers iodixanol and iotrolan, the lowest for diatrizoate, iopamidol, and iopromide, and intermediate values for iohexol and ioxaglate. The viscosity of iohexol and ioxaglate was found to vary linearly with temperature and quadratically with concentration. Whole-blood viscosity was measured for 5 subjects at high and low shear rates before and after mixing with contrast media in various proportions. Low-shear viscosity was found to decrease and high-shear viscosity to increase with contrast medium concentration. It is concluded that the contrast media currently used may affect blood rheology less than previous agents, despite their higher viscosity.

show abstract

Section: Discussioncontrasting

confidence: 82%

mentioning

confidence: 99%

Viscosity of Some Contemporary Contrast Media before and after Mixing with Whole Blood

Smedby¹

1992

Acta Radiol

View full text Add to dashboard Cite

show abstract

“…This result was interpreted as reflecting a decrease in erythrocyte aggregation and deformability. Smedby [9], Nguyen et al [10], Aspelin et al [11] and Staübli et al [12] reported that CM decreased erythrocyte aggregation proportionally to its concentration. They explained this phenomenon by modifications of erythrocyte morphology (formation of echinocytes).…”

Section: Discussionmentioning

confidence: 99%

Effects of Contrast Media on Blood Rheology: Comparison in Humans, Pigs, and Sheep

Laurent

Durussel

Dufaux

et al. 1999

Cardiovasc Intervent Radiol

View full text Add to dashboard Cite

At low CM concentration the blood viscosity was increased in pig, sheep, and humans and the disaggregation shear stress was increased in pig and humans. The aggregation of sheep blood was too low to be detected by the erythroaggregometer. This rise can be explained by the formation of poorly deformable echinocytes. At higher CM concentration, the viscosity and the disaggregation shear stress decreased in relation to the blood dilution. We conclude that pig blood and sheep blood can both be used to study the effect of CM injection on blood viscosity. Nevertheless, the rheologic behavior of pig blood in terms of erythrocyte aggregation is closer to that of human blood than is sheep blood when mixed with CM. Pigs could thus be more suitable than sheep for in vivo studies of CM miscibility with blood during selective cannulation procedures.

show abstract

“…STAUBLI et coll. (17) found that ioxaglate had less effect on the relative microviscosity (a measure of red cell deformability) than diatrizoate and metrizamide. Likewise, SCHMID-SCHONBEIN et coll.…”

Section: Discussionmentioning

confidence: 95%

Effect of contrast media on whole blood filtrability

et al. 1988

View full text Add to dashboard Cite

The effects of three contrast media, iohexol, iopamidol and ioxaglate, on rat erythrocytes were compared. Three parameters representative of the rheologic properties of blood were investigated: whole blood filtrability, red cell filtrability and morphology. Whole blood and red cell filtrabilities were both measured using an erythrometer and red cell morphology was observed with an optical microscope. Iohexol and iopamidol were found to cause a significant increase in filtrability indices and to modify the shape of red blood cells. Ioxaglate had less effect on these parameters than did the other two contrast media. The chemical structure seems to be a determining factor for red cell integrity. The study of blood rheology parameters in vitro may be useful as a model predictive of observations on human blood and of hemodynamic consequences.

show abstract

Changes in the Rheologic Properties of Blood as Induced by Sodium/Meglumine Ioxaglate Compared with Sodium/Meglumine Diatrizoate and Metrizamide

Cited by 11 publications

References 29 publications

Viscosity of Some Contemporary Contrast Media before and after Mixing with Whole Blood

Viscosity of Some Contemporary Contrast Media before and after Mixing with Whole Blood

Effects of Contrast Media on Blood Rheology: Comparison in Humans, Pigs, and Sheep

Effect of contrast media on whole blood filtrability

Contact Info

Product

Resources

About