Changes in the Vaginal Flora of Trichomoniasis Patients after Vaccination with SolcoTrichovac

Milovanović, R.; Grcić, R; Stojković, L

doi:10.1159/000269596

Cited by 3 publications

(1 citation statement)

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“…The vaccine was derived from heat-inactivated "abnormal strains of lactobacilli" that had been isolated from the vaginal secretions of women with trichomoniasis (99). These lactobacilli were reported to have lost the ability to produce lactic acid, and their morphology was described as shortened or coccoidal rather than the traditional elongated bacillus (90).…”

Section: Vaccinesmentioning

confidence: 99%

Treatment of Infections Caused by Metronidazole-ResistantTrichomonas vaginalis

et al. 2004

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Infections with the sexually transmitted protozoan Trichomonas vaginalis are usually treated with metronidazole, a 5-nitroimidazole drug derived from the antibiotic azomycin. Metronidazole treatment is generally efficient in eliminating T. vaginalis infection and has a low risk of serious side effects. However, studies have shown that at least 5% of clinical cases of trichomoniasis are caused by parasites resistant to the drug. The lack of approved alternative therapies for T. vaginalis treatment means that higher and sometimes toxic doses of metronidazole are the only option for patients with resistant disease. Clearly, studies of the treatment and prevention of refractory trichomoniasis are essential. This review describes the mechanisms of metronidazole resistance in T. vaginalis and provides a summary of trichomonicidal and vaccine candidate drugs

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Section: Vaccinesmentioning

confidence: 99%