Changes in treatment and outcome of oesophageal cancer in Denmark between 2004 and 2013

Kjær, Daniel Willy; Larsson, Heidi; Svendsen, Lars Bo; Jensen, Lone Susanne

doi:10.1002/bjs.10586

Cited by 29 publications

(30 citation statements)

References 36 publications

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“…In 2015, an increase in anastomotic leakages following esophageal resections was noted. In line with the findings of others, 18 , 22 this may well be attributed to learning curve problems following the introduction of the minimally invasive approach for esophageal resections.…”

Section: Discussionsupporting

confidence: 82%

“…Another possible effect of centralization is the rise in the proportion of patients with more than 15 lymph nodes identified in their specimen after surgery. 18 In line with the Danish experience, 18 compulsory adherence to the recommendation on centralization might lead to even more uniform treatment and possibly better outcomes for these patients. Inspired by the Danish example, 21 the Swedish Government launched the campaign Cancer Patient Pathways in 2015.…”

Section: Discussionmentioning

confidence: 91%

“… 17 Even so, NREV does not reach the same degree of completeness as comparable national registers in Denmark and The Netherlands. 18 , 19 The most likely reason is that, in contrast to the latter two registers, registration in NREV is still optional and not compulsory.…”

Section: Discussionmentioning

confidence: 99%

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Improvements in esophageal and gastric cancer care in Sweden-population-based results 2007–2016 from a national quality register

Jeremiasen

Linder

Hedberg

et al. 2019

Diseases of the Esophagus

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SUMMARY The Swedish National Register for Esophageal and Gastric cancer was launched in 2006 and contains data with adequate national coverage and of high internal validity on patients diagnosed with these tumors. The aim of this study was to describe the evolution of esophageal and gastric cancer care as reflected in a population-based clinical registry. The study population was 12,242 patients (6,926 with esophageal and gastroesophageal junction (GEJ) cancers and 5,316 with gastric cancers) diagnosed between 2007 and 2016. Treatment strategies, short- and long-term mortality, gender aspects, and centralization were investigated. Neoadjuvant oncological treatment became increasingly prevalent during the study period. Resection rates for both esophageal/GEJ and gastric cancers decreased from 29.4% to 26.0% (P = 0.022) and from 38.8% to 33.3% (P = 0.002), respectively. A marked reduction in the number of hospitals performing esophageal and gastric cancer surgery was noted. In gastric cancer patients, an improvement in 30-day mortality from 4.2% to 1.6% (P = 0.005) was evident. Overall 5-year survival after esophageal resection was 38.9%, being higher among women compared to men (47.5 vs. 36.6%; P < 0.001), whereas no gender difference was seen in gastric cancer. During the recent decade, the analyses based on the Swedish National Register for Esophageal and Gastric cancer database demonstrated significant improvements in several important quality indicators of care for patients with esophagogastric cancers. The Swedish National Register for Esophageal and Gastric cancer offers an instrument not only for the control and endorsement of quality of care but also a unique tool for population-based clinical research.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Improvements in esophageal and gastric cancer care in Sweden-population-based results 2007–2016 from a national quality register

Jeremiasen

Linder

Hedberg

et al. 2019

Diseases of the Esophagus

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“…Several studies have shown an inverse relationship between hospital volume of high‐risk upper gastrointestinal surgical procedures and postoperative mortality. To improve survival and decrease morbidity for patients with gastric cancer, centralization has been initiated in the Netherlands.…”

Section: Introductionmentioning

confidence: 99%

Overall survival before and after centralization of gastric cancer surgery in the Netherlands

Putten

Nelen

Lemmens

et al. 2018

British Journal of Surgery

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“…A survey published in 2013 reported that there were 450,000 new cases of esophageal cancer annually (4), and China accounts for more than half of all cases of this type of cancer (5). Each year, it is estimated that 150,000 individuals succumb to esophageal cancer in China, and the 5-year survival rate of patients is usually <30% (6)(7)(8). Esophageal cancer has two main subtypes, namely esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (9,10).…”

Section: Introductionmentioning

confidence: 99%

C-terminal binding protein‑2 mediates cisplatin chemoresistance in esophageal cancer cells via the inhibition of apoptosis

Shi

Mao

et al. 2018

Int J Oncol

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C-terminal binding protein‑2 (CtBP2) is a transcriptional co-repressor that is associated with tumorigenesis and tumor progression. It has been reported to predict a poor prognosis in several human cancers, including esophageal squamous cell carcinoma (ESCC). The present study aimed to investigate the involvement of CtBP2 in the cisplatin (DDP) resistance of the ECA109 ESCC cell line and its effect on the expression of apoptosis-associated proteins. Constructed recombinant lentiviruses were used for the knockdown or overexpression of CtBP2 in ECA109 cells, and the expression of CtBP2 was measured using reverse transcription-quantitative polymerase chain reaction and western blotting following transfection. MTT assays, Hoechst 33342 staining and flow cytometry (FCM) were applied to detect the influence of CtBP2 on the DDP-induced viability and apoptosis of the transfected ECA109 cells. In addition, the levels of apoptosis-associated proteins, including p53, B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein (Bax) and activated caspase-3 were investigated in the transfected ECA109 cells. Stable ECA109 cells with CtBP2 overexpression or knockdown were successfully established. The results of the MTT, Hoechst 33342 and FCM assays demonstrated that overexpression of CtBP2 attenuated the reduction of cell viability and inhibited the cell apoptosis induced by DDP. Furthermore, the western blotting results indicated that CtBP2 overexpression inhibited the DDP-induced apoptosis of ECA109 cells via the reduction of p53, activated caspase-3 and Bax expression, and promotion of Bcl‑2 expression. Therefore, the present study indicated that CtBP2 reduced the susceptibility of ECA109 cells to DDP by regulating the expression of apoptosis-related proteins, suggesting that it may be a promising therapeutic target in ESCC in the future.

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Changes in treatment and outcome of oesophageal cancer in Denmark between 2004 and 2013

Abstract: Indicators of quality of care have improved since the centralization of oesophageal cancer treatment in Denmark.

Cited by 29 publications

References 36 publications

Improvements in esophageal and gastric cancer care in Sweden-population-based results 2007–2016 from a national quality register

Improvements in esophageal and gastric cancer care in Sweden-population-based results 2007–2016 from a national quality register

Overall survival before and after centralization of gastric cancer surgery in the Netherlands

C-terminal binding protein‑2 mediates cisplatin chemoresistance in esophageal cancer cells via the inhibition of apoptosis

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