Changes in Triglyceride Levels Over Time and Risk of Type 2 Diabetes in Young Men

Abstract

OBJECTIVE -The association between changes in triglyceride concentrations over time and diabetes is unknown. We assessed whether two triglyceride determinations obtained 5 years apart can predict incident type 2 diabetes.RESEARCH DESIGN AND METHODS -Triglyceride levels at baseline (time 1) and 5 years later (time 2), followed by subsequent follow-up of 5.5 years, were measured in 13,953 apparently healthy men (age 26 -45 years) with triglycerides Ͻ300 mg/dl (Ͻ3.39 mmol/l).RESULTS -During 76,742 person-years, 322 cases of diabetes occurred. A multivariate model adjusted for age, BMI, total cholesterol-to-HDL cholesterol ratio, family history of diabetes, fasting glucose, blood pressure, physical activity, and smoking status revealed a continuous independent rise in incident diabetes with increasing time 1 triglyceride levels (P trend Ͻ 0.001). Men in the lowest tertile of time 1 triglyceride levels who progressed to the highest tertile over follow-up (low-high) exhibited a hazard ratio (HR) of 12.62 (95% CI 3.52-31.34) compared with those remaining in the lowest tertile at both time points (reference group: low-low). Whereas men who were at the top triglyceride level tertile throughout follow-up (high-high) had a HR for diabetes of 7.08 (2.52-14.45), those whose triglyceride level decreased to the lowest tertile (high-low) exhibited a HR of 1.97 (0.67-6.13). Alterations in triglyceride levels during follow-up were associated with changes in BMI, physical activity, and eating breakfast habit (P Ͻ 0.05), but remained an independent modifier of diabetes risk even after adjustment for such changes.CONCLUSIONS -Two measurements of fasting triglyceride levels obtained 5 years apart can assist in identifying apparently healthy young men at increased risk for diabetes, independent of traditional risk factors and of associated changes in BMI and lifestyle parameters.

Serum .GAMMA.-glutamyltransferase, triglyceride and total cholesterol are possible prediabetic risk markers in young Japanese men

“…Moreover, several cohort studies of older individuals have proposed that the TG level is an independent risk factor for diabetes [27,28]. A recent report demonstrated that TG levels of >120 mg/ dL, which is lower than that included in the criteria for metabolic syndrome (i.e., >150 mg/dL), were associated with greater diabetes risk compared with levels of < 66 mg/dL in young healthy males [29]. These findings also support our results.…”

Finding Influencing factors and probability to develop Diabetes Mellitus among adult hypertensive population in Puducherry (UT), South India: Hospital based retrospective study

“…HDL was a risk factor of development of non -insulin dependent diabetes in middle aged British men [11,12]. A study was done by Amir Tirosh et al [13] and demonstrated that the changes in triglyceride levels in over a time and it became a risk factor for diabetes in healthy young men [12,13]. Similar results were found in our present study that Triglyceride level is a risk factor for the progression or development of Type 2 DM in an individual.…”

Diabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults

“…Another potential explanation for the apparently conflicting reports in the literature may arise from lack of careful adjustment to the various risk factors (such as fasting glucose, HDL-cholesterol, triglycerides, and blood pressure) as continuous variables within risk factor groups. This is especially important in young adults, in whom diabetes risk attributed to increased levels of FPG, triglycerides, or WBCs could be demonstrated already within what is currently considered to be the normal range for these parameters (9,12,18). The definition of MH used in our study, along with an additional adjustment for other known risk factors (Fig.…”