Changes in urinary proximal tubule parameters in neonatal rats exposed to cadmium chloride during pregnancy

Saillenfait, Anne-Marie; Payan, Jean-Paul; Brondeau, M. T.; Zissu, D.; Céaurriz, J. de

doi:10.1002/jat.2550110105

Cited by 12 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such alterations correlated with an increase in the levels of early kidney injury biomarkers in amniotic fluid samples that are composed of fetal urine [ 42 ]. Similarly, a previous study presented evidence that repeated doses of Cd increased β2-microglobulin excretion and lower activity of γ-glutamyl transferase, alkaline phosphatase and N-acetylglucosaminidase in the urine of 3-day old rat pups, which suggested a reduced number of nephrons or a delayed tubular maturation [ 115 ]. All these renal outcomes could be the result of Cd-induced oxidative stress caused by lower levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) [ 110 ]; nevertheless, further studies are required to corroborate these conclusions.…”

Section: Effects Of CD In the Fetal Organismmentioning

confidence: 85%

“…Lastly, whether the renal effects caused by Cd gestational exposure are permanent or not, is still on debate because there is contrasting evidence that supports either possibility [ 34 , 115 ]. Discrepancies found may be the result of differences in the experimental models used, such as the period and length of exposure.…”

Section: Effects Of CD In the Fetal Organismmentioning

confidence: 99%

See 1 more Smart Citation

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Jacobo-Estrada

Santoyo-Sánchez

Thévenod

et al. 2017

IJMS

View full text Add to dashboard Cite

Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific articles had been published and listed by the website during 2017. Cadmium is one of the most common and harmful heavy metals present in our environment. Since pregnancy is a very particular physiological condition that could impact and modify essential pathways involved in the handling of Cd, the prenatal life is a critical stage for exposure to this non-essential element. To give the reader an overview of the possible mechanisms involved in the multiple organ toxic effects in fetuses after the exposure to Cd during pregnancy, we decided to compile some of the most relevant experimental studies performed in experimental models and to summarize the advances in this field such as the Cd distribution and the factors that could alter it (diet, binding-proteins and membrane transporters), the Cd-induced toxicity in dams (preeclampsia, fertility, kidney injury, alteration in essential element homeostasis and bone mineralization), in placenta and in fetus (teratogenicity, central nervous system, liver and kidney).

show abstract

Section: Effects Of CD In the Fetal Organismmentioning

confidence: 85%

Section: Effects Of CD In the Fetal Organismmentioning

confidence: 99%

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Jacobo-Estrada

Santoyo-Sánchez

Thévenod

et al. 2017

IJMS

View full text Add to dashboard Cite

show abstract

“…Delivery was at day O. Geometric mean _+ geometric SD of 10 rats. * p <0.05 (Kavlock et al 1986), methylmercury (Saillenfait et al 1989) or cadmium (Saillenfait et al 1991) have been shown to induce renal dysfunction in rats exposed during the prenatal period. The present study in rats demonstrates that maternal exposure to mercuric chloride can produce in mothers and their.litter a renal dysfunction resulting in an increased urinary excretion of albumin and beta2-microglobulin.…”

Section: Resultsmentioning

confidence: 95%

Renal effects of in utero exposure to mercuric chloride in rats

1992

View full text Add to dashboard Cite

The transplacental nephrotoxicity of mercuric chloride has been studied in female Sprague-Dawley rats. Mercuric chloride was injected s.c. to rats at the dose of 1 mg/kg during the last 8 gestational days or the whole pregnancy. Both mothers and newborns developed a transient renal dysfunction resulting in an increased urinary excretion of beta 2-microglobulin and albumin. In mothers and their female offspring, these effects were completely reversible and did not influence the subsequent evolution of the renal function. In the male offspring, however, transitory changes in protein excretion were again observed a few months later, concomitantly with an enhanced accumulation of alpha 2u-globulin in the kidney. The transfer of mercury from maternal to fetal tissues was very small. The kidney concentrations of mercury in newborns were more than 300 times lower than in mothers. The barrier role of the placenta is not sufficient to prevent the occurrence of renal effects in the offspring of rats treated with inorganic mercury during pregnancy.

show abstract

“…Several animal studies have evaluated the association between cadmium exposure and the risk of kidney functions during In utero or early life [128][129][130]. An In-vivo study demonstrated that accumulation of cadmium increases in the kidney from postnatal day 2 to postnatal day 60, where rats were exposed to cadmium through mother during the gestational period [130].…”

Section: Renal Dysfunctionsmentioning

confidence: 99%

Developmental toxicity of cadmium in infants and children: a review

Chandravanshi¹,

Shiv

Kumar

2021

Environ Anal Health Toxicol

View full text Add to dashboard Cite

effects and may not recover quite often. Chronic exposure of low-level cadmium may also occur via breast milk and cereals based complementary food, seafood, and vegetables for infants in mostly low-income families. [25][26][27]. Prenatal and postnatal cadmium exposures have been associated with a variety of adverse pregnancy outcomes including, malformations, decrease fetal growth rate, low birth weight, mortality, further, it may associated with the development of the various disease in children or later life [28][29][30][31]. A negative correlation between the cord blood level of cadmium and fetal growth has been observed in cadmium-exposed population in different areas of the world [30,32,33]. Urinary cadmium levels have been measured with Median cadmium concentrations 0.30, 0.16, and 0.30 g/L in the urine of 1.5, 5 years, and 3-month-old children. On the other hand, it's also observed that the concentration of cadmium in the infant's urine correlated with concentrations in maternal breast milk, saliva, and urine in a rural area of Bangladesh [34].Nutritional deficiencies and poor detoxification by affecting the process of methylation are other important factors that may increase the toxicity of cadmium [35]. Population-based studies on children and mothers have reported a correlation between In utero cadmium exposure and cord blood DNA methylation or birth weight [34,36]). Prenatal chronic exposure to cadmium influence the anthropometric development and growth of the fetus have been linked to later IQ (Intelligence quotient) development in children [34,37].A number of epidemiological studies have revealed that In utero and early life chronic exposure to cadmium may cause neurological problems including cognitive deficits, attention deficit hyperactivity disorder (ADHD), social, and attention in young and children [38][39][40]). Epidemiological studies were also found that children living in an area, contaminated with cadmium even at low exposure levels were associated with enhanced oxidative stress with DNA damage and protein modification in early life and associated with the higher risk of developing cardiovascular disease, osteoporosis and some types of cancer [41][42][43][44]. These are some possible mechanisms to monitor associations between In utero or early life cadmium exposure and susceptibility to chronic diseases.In this review, we organized the study to report, chronic cadmium exposure during In utero and early life and linked with long term health consequences and risk of pregnancy outcomes, neurological, cancer, and renal disease. MethodsA literature review has been conducted, using free literature search database 'PubMed' along with 'Google Search Engine. These sources were searched using keywords such as: cadmium or cadmium* and In utero*, early life*, prenatal*, postnatal*, perinatal*, gestational, lactational, developmental*, pregnancy outcomes, neurobehavioral, behavior*, cognitive dysfunctions IQ* cancer, renal disease, kidney dysfunction etc. All types of appropriate human and animal, stud...

show abstract

Changes in urinary proximal tubule parameters in neonatal rats exposed to cadmium chloride during pregnancy

Cited by 12 publications

References 20 publications

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Renal effects of in utero exposure to mercuric chloride in rats

Developmental toxicity of cadmium in infants and children: a review

Contact Info

Product

Resources

About