Changes Induced to Bull Spermatids and Testicular Spermatozoa by a Single Peritesticular Injection of Ethylene Dibromide

Amir, D.; Nicolle, J.C.; Courot, M.

doi:10.1111/j.1365-2605.1979.tb00049.x

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…A significant decrease in the UV-DNA and UV-protein contents of the elongating spermatids and testicular spermatozoa of bulls treated with a single peritesticular injection of 270 mg EDB was also reported (Fig. 8) (Amir et al, 1979).…”

Section: Mechanism Of Action Of Edbmentioning

confidence: 64%

“…The assumption that EDB interferes with the normal processes of nuclear chromatin condensation during spermiogenesis and sperm maturation in the epididymis was investigated by examining the changes in the weight, total nitrogen, lipoproteins, amino acids of the affected spermatozoa (Amir and Lavon, 1976), the area of these cells (Amir et al, 1977), and in the DNA and protein contents of the spermatids, epididymal and ejaculated spermatozoa of treated bulls (Amir et al, 1977(Amir et al, , 1979. Finally a n ultrastructural and ultracytochemical study was carried out to identify the specific stages of germ-cell differentiation that are sensitive to the treatment (Courtens et al, 1980).…”

Section: Mechanism Of Action Of Edbmentioning

confidence: 99%

“…Changes in the DNA and protein contents of bull spermatids and testicular spermatozoa 3, 4, and 5 days after a peritesticular injection of ethylene dibromide (adapted fromAmir et al, 1979). *P<0.05.…”

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confidence: 99%

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The spermicidal effect of ethylene dibromide in bulls and rams

Amir

1991

Molecular Reproduction Devel

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The spermicidal effect of ethylene dibromide (EDB) in bulls and rams is reviewed. Following oral or parenteral administration EDB was found to cause, by its alkylating effect in the testes of treated bulls and rams, lysis of the chromatin of the elongating spermatids during the time of somatin histones replacement by the sperm protamines. However, while in the bulls the abnormal spermatozoa issued from the affected spermatids were also collected in the ejaculates, this was not the case with treated rams. In the latter animals the abnormal spermatids seem to be phagocytized in the epididymis before their arrival in the ejaculate. In addition, whereas the alkylating effect of EDB occurred also in the upper parts of the epididymis of the bulls, causing tail and acrosome defects to the spermatozoa, in the rams such an effect seems to occur all along the epididymal duct. These differences between bulls and rams in the sites of the genital tract where the drug takes effect, and in the mechanism of this effect, reveal probable differences in the physiology of the reproductive tract between these species.

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Section: Mechanism Of Action Of Edbmentioning

confidence: 64%