Changes of ATPase activities in erythrocytes of rats with hypothalamic obesity

Calcium and Magnesium ATPase Activities in Women with Varying BMIs

“…Unlike Ca‐ATPase, Mg‐ATPase activity did not correlate linearly with BMI. However, in a subset of nine individuals completing the food frequency questionnaire, Mg‐ATPase showed a positive, although nonsignificant, curvilinear relationship with BMI that more closely resembles the increase in Mg‐ATPase activity seen in monosodium glutamate‐induced obese rats (11). It is noteworthy that although Ca‐ATPase correlated negatively with BMI, the positive correlation between Ca‐ATPase and Mg‐ATPase remained significant after controlling for BMI.…”

“…The intracellular calcium concentration is maintained at <0.1 μM in normotensive individuals by the plasma membrane enzyme calcium (Ca)‐ATPase (10). 1 Reduced Ca‐ATPase activity has been reported in various tissues of hypothalamic obese rats (11), obese fa/fa rats (12), and ob/ob mice (13). Vincenzi et al (14) have reported reduced Ca‐ATPase activity in erythrocytes from persons with hypertension but found no correlation between reduced calcium ATPase activity and body weight in this same group.…”

“…Mg‐ATPase is sensitive to membrane fatty acid composition (21), which is related to the activity of intracellular calcium‐stimulated fatty acid synthase, suggesting a possible synergistic relationship between Mg‐ATPase and Ca‐ATPase. In addition, Mg‐ATPase activity is increased in rats with monosodium glutamate‐induced hypothalamic obesity compared with control rats (11). We hypothesized that Mg‐ATPase would show a positive correlation with BMI and a positive correlation with Ca‐ATPase activity.…”