Changes of bispectral index during recovery from general anesthesia with 2% propofol and remifentanil in children

Park, Hyejin; Kim, Yong Lak; Kim, Chong Sung; Kim, Seong Deok; Kim, Hee-Soo

doi:10.1111/j.1460-9592.2006.02096.x

Cited by 24 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in contrast to a previous study with children after the surgical repair of congenital heart defects where even a small decrease in cardiac output resulted in a significant decline in cerebral oxygenation [5]. The reason for the increase in cerebral tissue oxygenation might be the decrease in oxygen consumption in a completely sedated brain with reduced electrocortical activity [9,14,22].…”

Section: Discussioncontrasting

confidence: 78%

Propofol Effect on Cerebral Oxygenation in Children with Congenital Heart Disease

et al. 2014

View full text Add to dashboard Cite

Propofol is a short-acting, intravenously administered hypnotic agent which is used in procedural sedation in children. Propofol is known to decrease systemic vascular resistance, arterial blood pressure and can lead to desaturations and decreased systemic perfusion in children with cardiac shunting. This may result in a reduction in cerebral blood flow and oxygenation. Near-infrared spectroscopy (NIRS) can monitor cerebral tissue oxygenation in the frontal neocortex. The objective of our study was to measure the changes in cerebral oxygen and blood supply after Propofol infusion in children with congenital heart disease. Propofol infusion may reduce cerebral oxygenation in children with congenital heart disease. The study group consisted of 32 children (f:m = 18:14), with median age of 49 (5-112) months and median weight of 15 (5-34) kg. We performed NIRS derived continuous measurement of cerebral oxygenation and cardiac output using Electrical velocimetry for 5 min before and after sedation with Propofol (1-2 mg/kg i.v.) for cardiac catheterization. Simultaneously, non-invasive arterial blood pressure and transcutaneous oxygen saturation were measured. Propofol sedation led to a significant decrease in mean arterial pressure (79 ± 16 vs. 67 ± 12 mmHg) (p = 0.01) and cardiac index (3.2 ± 0.8 vs. 2.9 ± 0.6 ml/min/m(2)) (p = 0.03). In contrast, cerebral tissue oxygenation index, increased significantly from 57 ± 11 to 59 ± 10 % (p < 0.05). Sedation with Propofol increased cerebral tissue oxygenation despite a decrease in cardiac index and arterial blood pressure. This may be caused by a decreased oxygen consumption of the sedated brain with intact cerebral auto-regulation.

show abstract

Section: Discussioncontrasting

confidence: 78%

Propofol Effect on Cerebral Oxygenation in Children with Congenital Heart Disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The Ce propofol at LOC in paediatric patients is significantly higher than in adults. Park's research showed a negative correlation between BIS and propofol plasma concentration [26]. Therefore, we can conclude that larger Ce propofol should be given in paediatric patients to get a similar anaesthetic depth and much larger Ce propofol should be given to get the same BIS values in younger individuals comparing to adults.…”

Section: Baseline Of Bis Loc Rocmentioning

confidence: 93%

Variation of bispectral index monitoring in paediatric patients undergoing propofol-remifentanil anaesthesia

Liu

Zhang²,

Yue³

2008

European Journal of Anaesthesiology

View full text Add to dashboard Cite

At loss of consciousness and regaining of consciousness, the bispectral index values of younger children group are significantly higher than those of adults. At the same stable concentrations of propofol, the bispectral index values are significantly different between children and adults. This study suggests that there is deviation when the adult algorithm of bispectral index monitoring is applied in paediatric patients under intravenous anaesthesia.

show abstract

“…Park et al aimed that their study was to investigate the relationship between BIS index and predicted plasma concentration of propofol delivered by target-controlled infusion during emergency in children. As a result they concluded that when respiration returned, mean BIS was 77.2 ± 5.3 and propofol plasma concentration 1.6 ± 0.3 μ g/kg and when a verbal command was obeyed, BIS was 82.4 ± 5.6 and propofol plasma concentration 1.5 ± 0.3 μ g/kg and BIS moderately correlated with the predicted plasma concentration of propofol [11]. Zhang et al reported that BIS effectively monitors the depth of intravenous anesthesia with remifentanil and propofol [12].…”

Section: Discussionmentioning

confidence: 99%

BIS-Guided Total Intravenous Anesthesia for Orchiopexy and Circumcision in a Child with Severe Autism: A Case Report

Okur

Arıkan

Temel

et al. 2012

Case Reports in Anesthesiology

View full text Add to dashboard Cite

Autistic children are very difficult to manage in the hospital setting because they react badly to any change in routine. We describe a case of 10-year-old male patient with severe autism undergoing orchidopexy and circumcision. Following premedication, anesthesia was induced with remifentanil, propofol, atracurium, and maintained with total intravenous anesthesia (propofol and remifentanil). The Bispectral Index System was monitored for determination of the depth of anesthesia. After surgery, all infusions were discontinued. The patient was then transferred to the postanesthetic care unit. There were no adverse events observed during the anesthetic management. The patient was discharged from the hospital on the second postoperative day. Bispectral Index System-guided Total Intravenous Anesthesia can provide some advantages for patient with autism, such as hemodynamic stability, early and easy recovery, to facilitate faster discharge, to optimize the delivery of anesthetic agents, to minimize its adverse effects, and to maximize its safety.

show abstract

Changes of bispectral index during recovery from general anesthesia with 2% propofol and remifentanil in children

Abstract: In preschool children, BIS moderately correlated with the predicted plasma concentration of propofol.

Cited by 24 publications

References 22 publications

Propofol Effect on Cerebral Oxygenation in Children with Congenital Heart Disease

Propofol Effect on Cerebral Oxygenation in Children with Congenital Heart Disease

Variation of bispectral index monitoring in paediatric patients undergoing propofol-remifentanil anaesthesia

BIS-Guided Total Intravenous Anesthesia for Orchiopexy and Circumcision in a Child with Severe Autism: A Case Report

Contact Info

Product

Resources

About