Changes of Energy Metabolism and Regional Cerebral Blood Flow Studied by Positron Emission Tomography in the Interictal Phase of Partial Epilepsy

Yamamoto, Y. Lucas; Ochs, Rachel; Ammann, W.; Meyer, Ernst; Evans, Alan C.; Cooke, B. E.; Izawa, Masahiro; Kato, Aitaro; Gloor, P.; Feindel, William; Dikšić, Mirko; Thompson, Christopher J.

doi:10.1007/978-3-7091-8726-5_4

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Interictal cortical hypometabolism is highly associated with the site of intracranial electrographic ictal onset and with localized structural imaging abnormality in our patients with partial epilepsies of neocortical origin. 'Diffuse hypometabolism' (as we define this type of regional hypometabolism) was seen more commonly than normal metabolism (58% versus 33% of the group studied) in patients with neocortical seizures, as is the case in mesial (limbic) temporal lobe epilepsy (TLE) 1' 3, 5,6,[8][9][10]14,19,21,[25][26][27][28]31. In these patients with neocortical seizures, any unilateral region of diffuse hypometabolism consistently included the smaller zone of intracranially recorded electrographic ictal onsets, as in mesial TEE 6. l~egions of diffuse hypometabolism included and were more widespread than associated cortical abnormalities on structural imaging and than histopathologic lesions in resected tissue of our patients with neocortical seizures, as in mesial TLE 3'2°.…”

Section: Discussionmentioning

confidence: 99%

Interictal cerebral metabolism in partial epilepsies of neocortical origin

et al. 1991

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We performed interictal [18F]fluorodeoxyglucose positron emission tomography (FDG PET) in 24 patients with partial epilepsy of neocortical origin. Two-thirds of patients had regions of hypometabolism. The zone of intracranially recorded electrographic ictal onset was always located in a region of hypometabolism, in those with hypometabolism. Hypometabolic regions in partial epilepsies of neocortical origin were usually associated with structural imaging abnormalities. Regional hypometabolism occasionally occurred without localizing ictal scalp EEG and cerebral magnetic resonance imaging findings, however. FDG PET may be useful in directing placement of intracranial electrodes for presurgical evaluation of refractory neocortical seizures.

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Section: Discussionmentioning

confidence: 99%

Interictal cerebral metabolism in partial epilepsies of neocortical origin

et al. 1991

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“…18-Fluorodeoxyglucose positron emission tomography (FDG-PET) of the brain is another test of focal functional integrity used in preoperative evaluation of temporal lobe epilepsy since 1977. Interictal tem-poral lobe hypometabolism in the hemisphere of seizure onset has been reported in as many as 70-88% of patients with refractory temporal lobe epilepsy (Engel et al, 1982a(Engel et al, ,b 1987Theodore et al, 1984;Yamamoto, 1984;Aboukhalil et al, 1987;Stefan et al, 1987). We wished to determine the relationship between functional localization by PET and by IAP in patients with a unilateral temporal epileptogenic focus.…”

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confidence: 99%

Comparison of the Intracarotid Amobarbital Procedure and Interictal Cerebral 18‐Fluorodeoxyglucose Positron Emission Tomography Scans in Refractory Temporal Lobe Epilepsy

et al. 1992

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The relationship between interictal focal hypometabolism determined by 18-fluorodeoxyglucose positron emission tomography (FDG-PET) scans and memory function with the intracarotid amobarbital procedure (IAP) was evaluated in 23 patients with temporal lobe epilepsy. All patients underwent prolonged EEG/video monitoring. The epileptogenic focus was defined by interictal epileptiform discharges and ictal onsets. All 23 patients had recorded seizures arising exclusively from one temporal lobe. PET showed temporal lobe hypometabolism ipsilateral to the epileptogenic focus in 86% (20 of 23) of patients; IAP showed impaired memory of the hemisphere of seizure onset in 65% (15 of 23). Sixty-five percent (13 of 20) of patients with focal hypometabolism had ipsilateral memory impairment. Memory impairment contralateral to the hypometabolic zone was not observed. Ninety-five percent (22 of 23) of patients demonstrated functional impairment by either PET or IAP (or both) on the epileptogenic side.

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“…This method gives a further indication for the selection of cases for surgery by demonstrating low glucose activity, oxygen usage and cerebral blood flow in the region of the epileptic EEG activity, a finding, however, which still demands further elucidation. 19 " 21 Diksic and Gjedde and others have also demonstrated an increased dopamine uptake in patients with temporal lobe epilepsy. These results represent an exciting approach by studies of neurotransmitter and receptor binding sites in the human epileptic brain.…”

Section: Brain Scanning In Epilepsymentioning

confidence: 96%

Development of Surgical Therapy of Epilepsy at the Montreal Neurological Institute

Feindel

1991

Can. J. Neurol. Sci.

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ABSTRACT:Wilder Penfield's development of surgical methods for treating focal cerebral seizures, beginning with his early work in Montreal in 1928, is reviewed. The reliance on seizure pattern and focal brain pathology was enormously enhanced by the advent of EEG and direct electrical recording from the cortex during surgery. The recognition in the early 1950's of mesial temporal structures in the pathogenesis of temporal lobe epilepsy with automatism lead to more rational and successful surgical treatment. Positron emission tomography and especially magnetic resonance imaging have recently added to the essential diagnostic information of focal epilepsy provided by EEG.

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Changes of Energy Metabolism and Regional Cerebral Blood Flow Studied by Positron Emission Tomography in the Interictal Phase of Partial Epilepsy

Cited by 8 publications

References 10 publications

Interictal cerebral metabolism in partial epilepsies of neocortical origin

Interictal cerebral metabolism in partial epilepsies of neocortical origin

Comparison of the Intracarotid Amobarbital Procedure and Interictal Cerebral 18‐Fluorodeoxyglucose Positron Emission Tomography Scans in Refractory Temporal Lobe Epilepsy

Development of Surgical Therapy of Epilepsy at the Montreal Neurological Institute

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