Changes of expression of endogenous sugar receptors by polymorphonuclear leukocytes after prolonged anaesthesia and surgery

Bárdosi, László; Bardosi, A.; Gabius, Hans‐Joachim

doi:10.1007/bf03008645

Cited by 18 publications

(10 citation statements)

References 30 publications

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“…Anaesthesia may have immunodepressive e#ects in mammals [6][7][8][9]25], but no attempts have been made to detect anaesthesia-induced immunodepression in fish. The present paper then, provides some novel information based on …”

Section: Discussionmentioning

confidence: 99%

“…In mammals, anaesthetic agents are known to depress phagocytic functions such as mobilisation, attachment, chemotactic motility, engulfment and intracellular killing [8]. A progressive decline in the expression of endogenous sugar receptors, such as mannose-specific receptors, on granulocytes during anaesthesia has been detected [8,25]. Considering that carbohydrate-lectin interactions play an important role in the activities of phagocytic cells, the above authors suggested that this depletion of lectin-like receptors could be the connection between anaesthesia and depression of the phagocytic function.…”

mentioning

confidence: 98%

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Effects of four anaesthetics on the innate immune response of gilthead seabream ( L.)

Ortuño

Esteban

Meseguer

2002

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

Effects of four anaesthetics on the innate immune response of gilthead seabream ( L.)

Ortuño

Esteban

Meseguer

2002

Fish & Shellfish Immunology

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“…However, only few studies have been undertaken to evaluate stress-re-Brought to you by | Michigan State University Authenticated Download Date | 7/2/15 9:52 AM lated changes of specific glycoproteins and lectins (28)(29)(30)(31)(32)(33)(34). However, only few studies have been undertaken to evaluate stress-re-Brought to you by | Michigan State University Authenticated Download Date | 7/2/15 9:52 AM lated changes of specific glycoproteins and lectins (28)(29)(30)(31)(32)(33)(34).…”

Section: Introductionmentioning

confidence: 99%

Changes of Glycoprotein Patterns in Sera of Humans under Stress

Barišić¹,

Lauc²,

Dumić³

et al. 1996

CCLM

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Stress exhibits adverse effects on many vital processes in which glycoproteins play a significant role (e. g. cell-cell/matrix interactions, immune response, neoplastic growth, implantation, prenatal development), yet only scarce attention has been directed towards studying stress induced changes in glycoprotein patterns. Using SDS-electrophoresis, blotting and digoxigenin-labelled lectins (Sambucus nigra agglutinin, Galanthus nivalis agglutinin, Datura stramonium agglutinin, Maackia amurensis agglutinin and peanut (Arachis hypogaea) agglutinin), sera were analysed from 30 individuals chosen randomly from a severely stressed population of 309 male volunteers with no specific medical symptoms. Significant changes were found in glycoprotein pattern and content, compared with healthy controls of matching age and sex. Occasionally minor non-specific deviations from the reference values for several analytes (haemoglobin, glucose, bilirubin and alanine aminotransferase) were detected in the tested group, but glycoprotein GP45 (Μ τ = 45 000), detected by Datura stramonium agglutinin and Sambucus nigra agglutinin, appeared in 96.7% of samples of the stressed population. The same population also revealed an approximately 500-fold increase of GP37 in comparison with the control sera. These results suggest that stress, as a non-specific syndrome, induces specific biochemical changes, which could be of diagnostic relevance as risk makers before any more serious symptoms of stress-related consequences have developed.

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“…Furthermore, nitrous oxide depresses the expression of endogenous sugar receptors on polymorphonuclear leukocytes and impairs intracellular signaling in leukocytes, resulting in the interference of the leukocyte adhesion-activation cascade (44,45). These observations clearly indicate that nitrous oxide acts as an anti-inflammatory molecule.…”

Section: Sevoflurane Group (N=26) Propofol Group (N=26) -------------mentioning

confidence: 91%

Effects of nitrous oxide on the production of cytokines and chemokines by the airway epithelium during anesthesia with sevoflurane and propofol

Kumakura

Yamaguchi

Sugasawa

et al. 2013

Molecular Medicine Reports

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Abstract. The aim of this study was to evaluate the effects of nitrous oxide (a gaseous anesthetic) on the in vivo production of inflammatory cytokines and chemokines by the airway epithelium, when combined with sevoflurane or propofol. Subjects undergoing simple or segmental mastectomy were randomly assigned to the sevoflurane and nitrous oxide, sevoflurane and air, propofol and nitrous oxide, or propofol and air group (all n=13). Epithelial lining fluid (ELF) was obtained using the bronchoscopic microsampling method prior to and following the mastectomy to enable measurement of the pre-and post-operative levels of certain inflammatory cytokines and chemokines using a cytometric bead array system. Notably, the levels of interleukin (IL)-1β, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Furthermore, the IL-12p70 levels were significantly reduced in the ELF following the operations that involved the inhalation of sevoflurane and air, although the IL-12p70 levels were not significantly changed by the inhalation of nitrous oxide and sevoflurane. These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1β, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway. Thus, the combination of these compounds should be carefully administered for anesthesia. IntroductionGlobally, >200 million major surgical procedures are undertaken annually (1), and nitrous oxide is widely used in anesthesia, often administered at an inspired concentration of ~60-70% (2-5). Nitrous oxide has achieved marked longevity as an anesthetic, having been used widely since 1844 (6). However, the low toxicity of modern anesthetic agents and the accumulating evidence on the adverse effects of nitrous oxide render the continued use of nitrous oxide in anesthesia controversial (7-10). A number of the adverse effects of nitrous oxide result from the irreversible inactivation of vitamin B 12 , which inhibits methionine synthase, folate metabolism and deoxyribonucleic acid synthesis (7,8). This mechanism explains the megaloblastic anemia and neurologic toxicity associated with prolonged nitrous oxide administration (11,12), and the possible risk of teratogenicity, immunodeficiency and impaired wound healing (7,13,14). In addition, the inhibition of methionine synthase is associated with increased plasma homocysteine concentrations (15,16) which may increase the risk of post-operative cardiovascular complications (15). Furthermore, nitrous oxide impairs cerebral blood flow-activity coupling (10), and worsens the air space conditions (such as pneumothorax and air embolism) and bowel distension (8,9). Nitrous oxide is also a risk factor for post-operative nausea an...

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Changes of expression of endogenous sugar receptors by polymorphonuclear leukocytes after prolonged anaesthesia and surgery

Cited by 18 publications

References 30 publications

Effects of four anaesthetics on the innate immune response of gilthead seabream ( L.)

Effects of four anaesthetics on the innate immune response of gilthead seabream ( L.)

Changes of Glycoprotein Patterns in Sera of Humans under Stress

Effects of nitrous oxide on the production of cytokines and chemokines by the airway epithelium during anesthesia with sevoflurane and propofol

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