Changes of Immunological Response after Experimentally Ozonated Autohemoadministration in Calves.

Terasaki, Nobuhiro; Ogata, Atsuya; Ohtsuka, Hiromichi; Tamura, Keiji; Hoshi, Fumio; Koiwa, Masateru; Kawamura, Seiichi

doi:10.1292/jvms.63.1327

Cited by 8 publications

(7 citation statements)

References 17 publications

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“…Previously, we reported increased B cells after OAHA in healthy calves following increased serum IL-6 activity [19]. Larini and Bocci [9] reported that exposure to ozone induced marked IL-4 production in isolated peripheral blood mononuclear cells, and discussed a significant relationship between cytokine production and ozone concentrations.…”

mentioning

confidence: 90%

“…Although ozone therapy has been reported to be effective in humans, the immune response to ozonated autohemotherapy has not been clarified in vivo, and the effect of ozonated autohemotherapy on peripheral leukocyte populations remains largely unknown in humans. Previously, we reported that ozonated autohemoadministration (OAHA) induced an increase of peripheral T cell and serum IL-6 activity in healthy calves [19]. But there have been no studies of peripheral lymphocyte populations after OAHA in cows with inflammatory diseases such as mastitis or arthritis.…”

mentioning

confidence: 99%

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Changes in Leukocyte Population after Ozonated Autohemoadministration in Cows with Inflammatory Diseases

Ohtsuka

Ogata²,

Terasaki³

et al. 2006

J. Vet. Med. Sci.

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ABSTRACT. In this study, we investigated whether ozonated autohemoadministration (OAHA) influences leukocyte populations in cows with clinical inflammatory disease. Eleven cows with inflammatory disease (Inflammatory Group) and three healthy cows (Control Group) were used for this study. The CD4 + /CD8 + ratio in the Inflammatory Group increased significantly compared to that in the Control Group 3 to 4 days after OAHA treatment. In the Inflammatory Group, the number of CD14 + cells decreased gradually after OAHA, but CD14 + levels remained stable in the Control Group. The number of MHC class-II + cells decreased gradually in the Inflammatory Group, but increased gradually in the Control Group, and the difference between the groups was significant on day 14 after OAHA. These findings suggest a possible difference in the activation of immune response after OAHA in infected cows compared to healthy cows. KEY WORDS: dairy cow, leukocyte population, ozonated autohemoadministration.

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confidence: 90%

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confidence: 99%

Changes in Leukocyte Population after Ozonated Autohemoadministration in Cows with Inflammatory Diseases

Ohtsuka

Ogata²,

Terasaki³

et al. 2006

J. Vet. Med. Sci.

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“…1995; Guennadi et al. 2008) properties that support its current application in medicine and dentistry (Terasaki et al. 2001; Guennadi et al.…”

Section: Introductionmentioning

confidence: 99%

“…A novel approach using ozone (O 3 ) containing products may be considered in the treatment of retained placenta as well, because of its reported bactericidal (Bocci 1996;Silva et al 2009), immune-stimulating (Buckley et al 1975;Jakab et al 1995;Zimran et al 2000;Guennadi et al 2008) and anti-inflammatory (Jakab et al 1995;Guennadi et al 2008) properties that support its current application in medicine and dentistry (Terasaki et al 2001;Guennadi et al 2008;Silva et al This research was carried out in the central part of Croatia (Moslavina region). Presented manuscript has been read and approved by all included authors.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ozone and Other Treatment Modalities for Retained Placenta in Dairy Cows

Zobel

Tkalčić

2012

Reprod Domestic Animals

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Contents Retained placenta is a worldwide recognized clinical condition in puerperal cows, which can significantly affect their health and fertility. Available treatment modalities are often of questionable efficacy or associated with time constraints, practicality or monetary considerations for their wide application in a routine dairy practice. The objective of this study was to compare and assess the efficacy of different treatment options, including a novel ozone treatment, for the retained placenta. Two hundred cows diagnosed with retained placenta were divided into five treatment groups, each receiving a different treatment option. Group A (n = 40) was given a combination treatment of intrauterine ozone and parenteral cephalexin; group B (n = 40) was given intrauterine ozone; group C (n = 40) was given a combination of parenteral cephalexin and intrauterine antibiotic tablets; group D (n = 40) was given only parenteral cephalexin and group E (n = 40) was given parenteral prostaglandins in 11‐day intervals. The control group (group Z, n = 200) included cows that gave birth without assistance and were not diagnosed with a retained placenta. The ozone treatment (groups A and B) was found to be the most effective modality resulting in the shortest period of days open, the smallest number of artificial inseminations until pregnancy, the smallest number of animals diagnosed with fever within 10 days post‐calving, the highest percentage of animals pregnant within 200 days after calving and the smallest number of animals culled because of infertility, when compared to the other treatment groups. The intrauterine ozone flush therefore has a potential as an efficacious and cost‐effective treatment option for retained placenta, with an overall positive effect on puerperal health and fertility in cows.

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“…1975; Mehlman and Borek 1987; Ogata and Nagahata 2000; Zimran et al. 2000; Terasaki et al. 2001; Ohtsuka et al.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ozone as a Novel Treatment Option for Urovagina in Dairy Cows

Zobel¹,

Tkalčić

Štoković

et al. 2011

Reprod Domestic Animals

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Urovagina is detrimental to the health and fertility of cows worldwide. Surgery, the only known treatment, is not economically pragmatic to dairy practice, and it has some medical drawbacks. The objective of this study was to determine whether reproductive problems associated with urovagina could be alleviated through more practical and less-invasive treatment options to allow successful conception and term-pregnancy. Cows diagnosed with urovagina (n = 1219) were divided into three treatment groups, each containing an equal number of cows with mild, moderate and severe urovagina. The groups received one of three treatment options: saline (group A, n = 400), streptomycin (group B, n = 400) or ozone (group C, n = 419) flush, regardless of the severity of the urovagina condition within the group. The ozone treatment was found to be the most effective treatment modality, resulting in the shortest period of days open (95, 89 and 79 days in groups A, B and C, respectively; p < 0.05), the fewest number of inseminations until pregnancy (2.38, 1.84 and 1.63 in groups A, B and C, respectively; p < 0.05) and the smallest number of culled cows (20, 23 and 12 in groups A, B and C, respectively; p < 0.05). The ozone flush coupled with intracornual insemination presents an effective treatment option for urovagina that can lead to successful conceptions and pregnancies in dairy cows.

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Changes of Immunological Response after Experimentally Ozonated Autohemoadministration in Calves.

Cited by 8 publications

References 17 publications

Changes in Leukocyte Population after Ozonated Autohemoadministration in Cows with Inflammatory Diseases

Changes in Leukocyte Population after Ozonated Autohemoadministration in Cows with Inflammatory Diseases

Efficacy of Ozone and Other Treatment Modalities for Retained Placenta in Dairy Cows

Efficacy of Ozone as a Novel Treatment Option for Urovagina in Dairy Cows

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