1987
DOI: 10.1203/00006450-198708000-00007
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Changes of Membrane Fluidity in Erythrocytes of Obese Children: A Spin Label Study

Abstract: ABSTRACf. Red blood cells depend on circulating lipoproteins for the turnover of membrane phospholipids. Thus abnormalities in lipid and lipoprotein metabolism are frequently associated with changes in composition and fluidity of erythrocyte membranes. Using the electron spin resonance technique we studied the physical state of erythrocyte membranes from 15 obese children with a body mass index ranging from 22.8 to 34 kg. m"? and slight alterations of plasma lipids. The spin labels used, S-doxylstearate and 16… Show more

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Cited by 10 publications
(4 citation statements)
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“…1 Changes in composition and in molecular organisation are the principal determinants of alterations of membrane fluidity observed in many human diseases. [22][23][24][25][26][27] In this study we used the fluorescence polarisation of 1,6-diphenyl-1,3,5-hexatriene (DPH), which has been widely used to analyse membrane fluidity of blood cells in normal and pathological conditions.2>27 The lipophilic probe DPH, though primarily embedded in the plasma membrane, is not located exclusively there, but also penetrates the intracellular membranes, thus characterising all cell membrane apparatus.28…”
mentioning
confidence: 99%
“…1 Changes in composition and in molecular organisation are the principal determinants of alterations of membrane fluidity observed in many human diseases. [22][23][24][25][26][27] In this study we used the fluorescence polarisation of 1,6-diphenyl-1,3,5-hexatriene (DPH), which has been widely used to analyse membrane fluidity of blood cells in normal and pathological conditions.2>27 The lipophilic probe DPH, though primarily embedded in the plasma membrane, is not located exclusively there, but also penetrates the intracellular membranes, thus characterising all cell membrane apparatus.28…”
mentioning
confidence: 99%
“…In particular, rats deficient in unsaturated fatty acids have been shown to have a 30% decrease in glucose uptake into the brain, although GLUT1 and GLUT3 surface protein levels were unchanged 77 . Although free fatty acids (FFA) are naturally present in low amounts of cell membranes (0.3 to 10% total lipids), they rise to very high levels in obese patients and affect membrane bilayer fluidity 78 , 79 . It is well-known that increased FFA is associated with both an increase in insulin resistance and the development of type 2 diabetes 78 , 80 .…”
Section: Discussionmentioning
confidence: 99%
“…In particular, rats deficient in unsaturated fatty acids have been shown to have a 30% decrease in glucose uptake into the brain, although GLUT1 and GLUT3 surface protein levels were unchanged 75 . Although free fatty acids (FFA) are naturally present in low amounts of cell membranes (0.3 to 10% total lipids), they rise to very high levels in obese patients and effect membrane bilayer fluidity 76,77 . It is well-known that increased FFA is associated with both an increase insulin resistance and the development of type 2 diabetes 76,78 .…”
Section: Discussionmentioning
confidence: 99%