Changes of parainfluenza virus infection in children before and after the COVID-19 pandemic in Henan, China

Li, Lifeng; Jia, Rui; Zhang, Yaodong; Sun, Huiqing; Ma, Jiayue

doi:10.1016/j.jinf.2023.02.009

Journal of Infection

2023

DOI: 10.1016/j.jinf.2023.02.009

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Changes of parainfluenza virus infection in children before and after the COVID-19 pandemic in Henan, China

Lifeng Li

Rui Jia

Yaodong Zhang

et al.

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Cited by 9 publications

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Epidemiological, Clinical, and Genomic Traits of PIV in Hospitalized Children After the COVID‐19 Pandemic in Wuhan, China

Huang,

Li,

Chen

et al. 2024

Journal of Medical Virology

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Human parainfluenza virus (PIV) is a main cause of acute lower respiratory tract infections (ALRTIs), which contributes to childrens' mortality worldwide; however, the epidemiology of PIVs following the SARS‐CoV‐2 pandemic is still not clarified, and poses risks of potential outbreaks. Herein, we conducted a retrospective observational study from September 26, 2020 to September 30, 2023 to assess PIV epidemiology in Wuhan, China, as well as the clinical characteristics of PIV infections. In total, 14,065 inpatients with ALRTIs were enrolled, of which 936 were identified to have PIV infection. We also obtained 69 PIV3 RNA to reveal its molecular traits. An alteration in PIV season pattern away from spring and summer prevalence was noted, as well as a progressive rise in its detection rate. PIV‐related ALRTIs were more prevalent in male patients. PIV3 was the dominant PIV type in recent years. In comparison with the phase before the cancellation of Dynamic Zero‐COVID Policy in December 2022, symptoms after its repeal were milder. All Wuhan strains were classified with C3f lineage and possibly evolved from native strains in China. Additionally, some mutations, such as Q499P in protein hemagglutinin‐neuraminidase, should be given further attention. In summary, our study demonstrates the clinical characteristics of PIVs and genomic traits of PIV3 in Wuhan, China, thus holds importance for the diagnosis and control of PIV infections in the post‐pandemic era.

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Epidemiological, Clinical, and Genomic Traits of PIV in Hospitalized Children After the COVID‐19 Pandemic in Wuhan, China

Huang,

Li,

Chen

et al. 2024

Journal of Medical Virology

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Increasing rhinovirus prevalence in paediatric intensive care patients since the SARS-CoV2 pandemic

Gil

Roy

Best

et al. 2023

Journal of Clinical Virology

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Effects of COVID-19 pandemic on epidemiological features of viral respiratory tract infections in children: a single-centre study

Bedir Demirdag,

Ozcicek,

Polat

et al. 2024

Epidemiol. Infect.

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The epidemiology of respiratory infections may vary depending on factors such as climate changes, geographical features, and urbanization. Pandemics also change the epidemiological characteristics of not only the relevant infectious agent itself but also other infectious agents. This study aims to assess the impact of the COVID-19 pandemic on the epidemiology of viral respiratory infections in children. We retrospectively reviewed the medical records of children aged ≤18 years with laboratory-confirmed viral respiratory infections other than COVID-19 from January 2018 to March 2023. Data on demographic characteristics, month and year of admission, and microbiological results were collected. During the study period, 1,829 respiratory samples were sent for polymerase chain reaction testing. Rhinovirus was identified in 24% of the patients, mixed infections in 21%, influenza virus in 20%, and respiratory syncytial virus in 12.5%. A 38.6% decrease in viral respiratory infections was observed in 2020, followed by a 188% increase in 2021. The respiratory syncytial virus was significantly more common in the post-pandemic period (13.8%) compared to the pre-pandemic period (8.1%), but no seasonal shift in respiratory syncytial virus infection was observed. There was also a yearly increase in influenza infections in the post-pandemic period compared to the pre-pandemic period. After the COVID-19 pandemic, the frequency of parainfluenza virus infections increased during the summer months, and this finding provides a new contribution to the existing literature.

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Changes of parainfluenza virus infection in children before and after the COVID-19 pandemic in Henan, China

Cited by 9 publications

References 9 publications

Epidemiological, Clinical, and Genomic Traits of PIV in Hospitalized Children After the COVID‐19 Pandemic in Wuhan, China

Epidemiological, Clinical, and Genomic Traits of PIV in Hospitalized Children After the COVID‐19 Pandemic in Wuhan, China

Increasing rhinovirus prevalence in paediatric intensive care patients since the SARS-CoV2 pandemic

Effects of COVID-19 pandemic on epidemiological features of viral respiratory tract infections in children: a single-centre study

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