Changes of porous poly(ε-caprolactone) bone grafts resulted from e-beam sterilization process

Sterilization techniques for biodegradable scaffolds in tissue engineering applications

“…Furthermore, as shown in Table 3 , e-beam sterilization results vary significantly from materials to materials, depending primarily on chemical bonds and linkages of individual materials. 16 , 23 , 44 Therefore, the effect of e-beam sterilization on a specific biomaterial must be thoroughly investigated in pilot studies before this technique can be fully implemented for a particular application. While both radiation sterilization techniques have shortcomings, they are still considered promising candidates for sterilizing degradable scaffolds among all currently available techniques; however, key operating conditions such as radiation dosage and scaffold material moisture must be sufficiently studied in pilot studies and carefully controlled.…”

Effect of electron beam irradiation on the silk fibroin fiber/poly(ε‐caprolactone) composite

“…The influences of irradiation on the mechanical and optical properties, processability, and thermal stability of PCL were investigated by Yoshii and coworkers12–14 Ohrlander et al15 and Filipczak et al16 discussed the formation of free radicals in PCL after irradiation through electron paramagnetic resonance (EPR) analysis. The effects of irradiation on PCL porous scaffolds were also studied as well as the bulk polymer 17, 18. Irradiation is also used as a tool for silk fiber modification and grafting 19–22.…”

Effect of sterilization on structural and material properties of 3-D silk fibroin scaffolds

“…Thus a ster-53 ilization process is used to inactivate potentially present microbial 54 contaminants. As this is usually achieved through denaturing con- to be a function of the irradiation dose [7]. Ethylene oxide (EO) 76 treatment, on the other hand, was less damaging in terms of 77 molecular weight loss, but had a profound effect on the scaffold's 78 morphology [6].…”