Kota, an Indian metropolis, has been experiencing high particulate matter pollution for the last few years. The primary aim of this study is to perform a human health risk assessment caused by particulate matter concentrations for Kota Metropolis. The annual PM2.5 and PM10 concentrations for Kota Metropolis were 52.63 and 106.86 µg/m3, respectively, indicating the violation of Indian NAAQS. The PM2.5 induced long-term ENACs for mortality due to all-natural causes in adults, LC, ALRI, COPD, IHD, and Stroke were 4624, 819, 258, 440, 1976, and 1791, respectively, while short-term ENACs for hospital admission due to respiratory disease, cardiovascular disease, and all-cause mortality in adults were 1288, 50, and 679, respectively. The PM10 induced long-term ENACs for postneonatal infant mortality, chronic bronchitis incidences (adults), and pervasiveness of bronchitis in kids were 317131, 13448, and 700, respectively. The study presents important conclusions to stakeholders and policymakers to implement suitable mitigation measures.