Changes of serum and peritoneal inflammatory mediators in laparoscopic radical resection for right colon carcinoma

Zhu, Pengcheng; Miao, Wenzhong; Gu, Feng; Chen, Xing

doi:10.4103/jmas.jmas_217_17

Cited by 5 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have suggested that the crosstalk between cancer cells and host’s stromal cells may participate in the establishment of a permissive tumoral environment that subsequently favors residual disease growth and chemoresistance [ 5 – 11 ]. However, only few studies have provided a global approach, considering the macro-environmental changes associated with surgery [ 12 – 14 ]. Beyond cell–cell interactions, peritoneal trauma induced by surgery may also participate in the constitution of a niche for residual cancer cells through overproduction of secreted factors.…”

Section: Introductionmentioning

confidence: 99%

Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8

et al. 2018

View full text Add to dashboard Cite

BackgroundThe mainstay of treatment of advanced ovarian cancer (AOC) involves chemotherapy, and debulking surgery. However, despite optimal surgical procedure and adjuvant chemotherapy, 60% of patients with AOC will relapse within 5 years. Most recurrences occur in the peritoneal cavity, suggesting the existence of occult sanctuaries where ovarian cancer cells (OCC) are protected. In murine models, surgical stress favors tumor growth; however, it has never been established that surgery may affect OCC sensitivity to subsequent chemotherapy. In this study, we investigated how the surgical stress could affect the chemosensitivity of OCC.MethodsTo avoid bias due to tumor burden in peritoneal cavity and duration of surgery, we used peritoneal biopsies from patients without a malignancy at precise time points. During laparotomies, peritoneal biopsies at the incision site were performed at the time of incision (H0 sample) and 1 h after initiation of surgery (H1 sample). We evaluated the chemoresistance to Taxol (0–20 µM) induced by H0 or H1 incubation (24 h) in two ovarian cancer cell lines OVCAR3 and SKOV3 and a primary cancer cell lines derived in our laboratory.ResultsOur results indicate that stressed peritoneum overexpressed cytokines, resulting in OCC increased resistance to therapy. Among these cytokines, IL8 was responsible for the resistance to apoptosis through the AKT pathway activation. Chemoresistance in OCC persists through the establishment of an autocrine IL8 loop. Finally, in a cohort of 32 patients, we showed an impact of IL8 tumoral overexpression on chemosensitivity and survival outcomes with a significant association to earlier recurrence.ConclusionsOur study demonstrated that precision surgery where targeted treatment would be used in combination with surgery is essential to obtain better tumor control.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1643-z) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8

et al. 2018

View full text Add to dashboard Cite

show abstract

Postoperative inflammatory response in colorectal cancer surgery: a meta-analysis

Kampman,

Smalbroek,

Dijksman

et al. 2023

Int J Colorectal Dis

View full text Add to dashboard Cite

Impact of laparoscopic versus open surgery on humoral immunity in patients with colorectal cancer: a systematic review and meta-analysis

Bohne,

Grundler,

Knüttel

et al. 2023

Surg Endosc

View full text Add to dashboard Cite

Background Laparoscopic surgery (LS) is hypothesized to result in milder proinflammatory reactions due to less severe operative trauma, which may contribute to the observed clinical benefits after LS. However, previous systematic reviews and meta-analyses on the impact of LS on immunocompetence are outdated, limited and heterogeneous. Therefore, the humoral response after laparoscopic and open colorectal cancer (CRC) resections was evaluated in a comprehensive systematic review and meta-analysis. Methods Included were randomized controlled trials (RCTs) measuring parameters of humoral immunity after LS compared to open surgery (OS) in adult patients with CRC of any stage. MEDLINE, Embase, Web of Science (SCI-EXPANDED), Cochrane Library, Google Scholar, ClinicalTrials.gov and ICTRP (World Health Organization) were systematically searched. Risk of bias (RoB) was assessed using the Cochrane RoB2 tool. Weighted inverse variance meta-analysis of mean differences was performed for C-reactive protein (CRP), interleukin (IL)-6, IL-8, tumour necrosis factor (TNF)α and vascular endothelial growth factor (VEGF) using the random-effects method. Methods were prospectively registered in PROSPERO (CRD42021264324). Results Twenty RCTs with 1131 participants were included. Narrative synthesis and meta-analysis up to 8 days after surgery was performed. Quantitative synthesis found concentrations to be significantly lower after LS at 0–2 h after surgery (IL-8), at 3–9 h (CRP, IL-6, IL-8, TNFα) and at postoperative day 1 (CRP, IL-6, IL-8, VEGF). At 3–9 h, IL-6 was notably lower in the LS group by 86.71 pg/ml (mean difference [MD] − 86.71 pg/ml [− 125.05, − 48.37], p < 0.00001). Combined narratively, 13 studies reported significantly lower concentrations of considered parameters in LS patients, whereas only one study reported lower inflammatory markers (for CRP and IL-6) after OS. Conclusion The increase in postoperative concentrations of several proinflammatory parameters was significantly less pronounced after LS than after OS in this meta-analysis. Overall, the summarized evidence reinforces the view of a lower induction of inflammation due to LS.

show abstract

Changes of serum and peritoneal inflammatory mediators in laparoscopic radical resection for right colon carcinoma

Abstract: Laparoscopic surgery for the treatment of right colon carcinoma has the advantages of fewer traumas, less systemic and local inflammatory response, rapider post-operative recovery and shorter hospital stay. It is worthy of clinical application.

Cited by 5 publications

References 14 publications

Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8

Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8

Postoperative inflammatory response in colorectal cancer surgery: a meta-analysis

Impact of laparoscopic versus open surgery on humoral immunity in patients with colorectal cancer: a systematic review and meta-analysis

Contact Info

Product

Resources

About