Changes of Serum Zinc-α2-Glycoprotein Level and Analysis of Its Related Factors in Gestational Diabetes Mellitus

Abstract

Previous studies have discovered that zinc-α2-glycoprotein (ZAG) is related to insulin resistance and lipid metabolism. The aim of the study is to explore the change of serum ZAG and its related factors in gestational diabetes mellitus (GDM). Eighty newly diagnosed GDM patients were enrolled in the case group, and 80 normal pregnant women were selected as the control group. The differences of baseline data between the two groups were compared, and the change of serum ZAG level and its relationship with related indexes was analyzed. Compared to the control group, the level of serum ZAG in GDM women decreased ( P < 0.001 ). What is more, the serum ZAG level of overweight and normal subjects in two groups was also found to have statistical differences. The Pearson correlation (or Spearman correlation) analysis showed that serum ZAG level was negatively correlated with FPG, FINS, HOMA-IR, and TG (all P < 0.05 ) and positively correlated with HDL ( P < 0.05 ). Multiple linear regression showed that HDL and HOMA-IR were independent factors of serum ZAG ( P < 0.05 ). The level of serum ZAG in patients with gestational diabetes mellitus decreased, and HDL and HOMA-IR are the influencing factors in the case group.

The Treatment of Gestational Diabetes Mellitus

“…Some studies also believe that intrauterine hyperglycemia environment is related to children's obesity, including overweight or obesity, body fat rate, skin fold thickness and waist circumference [20]. Some studies have pointed out that among pregnant women with gestational diabetes, fasting blood glucose in OGTT, pre pregnancy body mass index, and pregnancy weight growth are independent risk factors for macrosomia; when the fasting blood glucose in OGTT was >5.185 mmol/L, the BMI before pregnancy was >23.02 kg/m 2 , and the body mass growth during pregnancy was >13.75 kg, the risk of macrosomia in GDM pregnant women was significantly increased; Macrosomia increases the risk of postpartum hemorrhage in GDM pregnant women [21]. Some studies have pointed out that the elderly and OGTT fasting blood glucose increase is independent risk factors for spontaneous preterm delivery in pregnant women with diabetes [22].…”

Evaluation of Serum Urocortin 3 in acne vulgaris patients

“…In addition, stress and lack sleep may cause hormonal shifts and inflammation, which contribute to acne outbreaks [22]. [25].…”

Expression and diagnostic value of lncRNA HCG18 in gestational diabetes mellitus

“…Referring to the Chinese diagnostic criteria of GDM, fasting blood glucose at 5.1 mmol/L, 1 hour after taking glucose at 10.0 mmol/L, and 2 hours after taking glucose at 8.5 mmol/L were taken as the critical blood glucose. Gestational diabetes mellitus was diagnosed when the fasting blood glucose level or the blood glucose level diagnosed by 75 g OGTT after 24 weeks of gestation was greater than the critical blood glucose level [16]. In addition to GDM, the participants were routinely examined to exclude diseases such as multiple pregnancy, and the participants' age, body mass index (BMI), pregnancy period, blood glucose and other clinical data were recorded and counted.…”