Changes of Thymoquinone, Thymol, and Malondialdehyde Content of Black Cumin ( Nigella sativa L.) in Response to Indonesia Tropical Altitude Variation

Herlina, .; Aziz, Sandra Arifin; Kurniawati, Ani; Faridah, Didah Nur

doi:10.1016/j.hjb.2017.08.004

Cited by 31 publications

(16 citation statements)

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“…The present study shows that N. sativa oil obtained from a cultivar produced in the region Marche, located in central Italy, contains a higher thymoquinone content (7.200 mg/mL, Table 1) compared with other cultivars from the Mediterranean area, Asia, and Indonesia [8,9,20]. The level of thymoquinone is related to the fresh extraction from well-preserved seeds, while its content decreases significantly on oil storage (4.767 mg/mL, Table 1).…”

Section: Discussionmentioning

confidence: 86%

Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes

et al. 2019

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The oil obtained from the seeds of Nigella sativa L. (N. sativa), also known as black cumin, is frequently used in the Mediterranean area for its anti-inflammatory, anti-oxidant, and anti-cancer activities. The aim of the present study was to evaluate the antioxidant and anti-inflammatory properties of the oil extracted from seeds of a N. sativa cultivar produced in the Marche region of Italy, and to determine if the thymoquinone content, antioxidant properties, and biological activity would decay during storage. Cytotoxicity and anti-inflammatory properties of N. sativa oil were tested in an in vitro model of low-grade inflammation in Simpson–Golabi–Behmel syndrome human pre-adipocytes. The fresh extracted oil (FEO) contained 33% more thymoquinone than stored extracted oil (SEO), demonstrating that storage affects its overall quality. In addition, the thymoquinone content in the N. sativa oil from the Marche region cultivar was higher compared with other N. sativa oils produced in the Middle East and in other Mediterranean regions. Pro-inflammatory cytokines (e.g., Interleukin (IL)-1alpha, IL-1beta, IL-6) were differently modulated by fresh and stored extracts from N. sativa oils: FEO, containing more thymoquinone reduced IL-6 levels significantly, while SEO inhibited IL-1beta and had a higher antioxidant activity. Total antioxidant activity, reported as µM of Trolox, was 11.273 ± 0.935 and 6.103 ± 0.446 for SEO and FEO (p = 1.255 × 10−7), respectively, while mean values of 9.895 ± 0.817 (SEO) and 4.727 ± 0.324 (FEO) were obtained with the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay (p = 2.891 × 10−14). In conclusion, the oil capacity to counteract proinflammatory cytokine production does not strictly depend on the thymoquinone content, but also on other antioxidant components of the oil.

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Section: Discussionmentioning

confidence: 86%

Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes

et al. 2019

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“…The quantity of most important bioactive constituent, thymoquinone, present in the volatile oil isolated by different extraction methods from the seeds of N. sativa varied over a wide range: using SC-CO 2 (1.06, 4.07 mg/g) [16] and by Soxhlet extraction (2940.43 mg/kg) [17] and (8.8 mg/g) oil [18].…”

Section: High-value Bioactive Compounds (Phytochemicals) In the Sementioning

confidence: 99%

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Yimer

Tuem

Karim

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of N. sativa against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy. Moreover, the strong antioxidant property of this valued seed has recently gained increasing attention with regard to its potential role as dietary supplement with minimal side effects. Besides, when combined with different conventional chemotherapeutic agents, it synergizes their effects resulting in reducing the dosage of concomitantly used drugs with optimized efficacy and least and/or no toxicity. A number of pharmaceutical and biological properties have been ascribed to seeds of N. sativa. The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.

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“…As for their applicability, both studies presented adequate evidence in favor of using N. sativa in patients with hypertension, mainly because of the feasibility and safety. N. sativa is easily found in Indonesia and has been empirically used in Indonesia as dietary supplements [17]. The reported adverse events in both studies were minimal, hence strengthening their applicability.…”

Section: Discussionmentioning

confidence: 75%

Antihypertensive Effects of Nigella Sativa: Weighing the Evidence

et al. 2019

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Objective: Hypertension causes 7.5 million deaths annually worldwide. Antihypertensive drugs cause side effects, potentially leading to non-adherence, hence uncontrolled hypertension and increased risk of cardiovascular morbidity and mortality. Therefore, there has been increasing interest in alternative pharmacological treatments for hypertension, one of which is black cumin, or Nigella sativa, a traditional medicine that has been empirically used. This evidence-based case report aims to evaluate the current evidence for the effectiveness of Nigella sativa in reducing blood pressure in a mildly hypertensive patient. Methods: A literature search was performed on MEDLINE, TRIP Database, Clinical Key, ScienceDirect, and DynaMed, using the keywords “nigella sativa”, “hypertension”, and “blood pressure” with all their synonyms and related terms. The included studies were two systematic reviews and two clinical trials, which were then critically appraised. Results: Out of the four studies, three were considered valid. In terms of importance, Sahebkar et al. showed a reduction of the weighted mean difference (WMD) by Nigella sativa: −3.26 mmHg, 95% CI: −5.10, −1.42, I2 = 59% for systolic blood pressure and WMD: −2.80 mmHg, 95% CI: −4.28, −1.32, I2 = 60% for diastolic blood pressure. Badar et al. concluded that Nigella sativa significantly reduced systolic and diastolic blood pressure compared with the control group. Two studies were considered applicable to our patient in question. Conclusion: The current evidence for the effect of Nigella sativa in lowering blood pressure is limited. However, one study gives strong evidence for significant antihypertensive effects of Nigella sativa. In mild hypertension, Nigella sativa could be one of the therapeutic options.

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Changes of Thymoquinone, Thymol, and Malondialdehyde Content of Black Cumin ( Nigella sativa L.) in Response to Indonesia Tropical Altitude Variation

Cited by 31 publications

References 13 publications

Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes

Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Antihypertensive Effects of Nigella Sativa: Weighing the Evidence

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