Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions

Li, Yuyuan; Sun, Ying; Li, Jian; Wang, Zhe; Lin, Yongzhong; TANG, Ling; Xia, Dandan; Zheng, Tiezheng; Yang, Xin; Li, Sha; Sun, C.K.

doi:10.1016/j.jns.2015.07.033

Cited by 10 publications

(11 citation statements)

References 48 publications

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“…15 In patients with white matter lesions, increased serum UCH-L1 levels were correlated with white matter lesion severity. 30 Taken together, these data and findings from the present study suggest that serum UCH-L1 level has potential as a predictive marker for cognitive impairment after AOPP. This study showed that serum UCH-L1 levels >5.9 ng/mL could predict the development of cognitive impairment after AOPP with relatively high sensitivity and specificity.…”

Section: Baseline Characteristics Of the Study Patientssupporting

confidence: 77%

Serum ubiquitin C‐terminal hydrolase L1 predicts cognitive impairment in patients with acute organophosphorus pesticide poisoning

Pang

Liu

et al. 2019

Clinical Laboratory Analysis

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BackgroundTo assess the usefulness of serum C‐terminal hydrolase L1 (UCH‐L1) level as a biomarker for predicting cognitive impairment in patients with acute organophosphorus pesticide poisoning (AOPP).MethodsTwo hundred and seven adult patients with AOPP were included in this study. Serum UCH‐L1 levels were assessed on admission (Day 1 postpoisoning) and on Days 3 and 7 postpoisoning. The associations between serum UCH‐L1 levels, other clinical predictors, and cognitive function evaluated on Day 30 postpoisoning were investigated.ResultsOn multivariate analysis, serum UCH‐L1 levels on admission (odds ratio [OR] 1.889, 95% confidence interval [CI] 1.609‐3.082, P = 0.002) and 24‐hour APACHE II score (OR 1.736, 95% CI 1.264‐3.272, P = 0.012) were independent predictors of cognitive impairment on Day 30 postpoisoning. Based on the receiver operating characteristic curve, serum UCH‐L1 levels >5.9 ng/mL on admission predicted cognitive impairment on Day 30 postpoisoning with 86.1% sensitivity and 72.5% specificity (area under the curve, 0.869; 95% CI 0.815‐0.923). On admission [8.51 (6.53‐10.22) ng/mL vs 4.25 (2.57‐6.31) ng/mL, P < 0.001] and Day 3 [9.31 (7.92‐10.98) ng/mL vs 3.32 (2.25‐5.13) ng/mL, P < 0.001] and Day 7 [4.96 (3.28‐7.26) ng/mL vs 2.27 (1.55‐3.24) ng/mL, P < 0.001] postpoisoning, serum UCH‐L1 concentration was significantly higher in patients that developed cognitive impairment compared to those that did not.ConclusionThis study demonstrates that serum UCH‐L1 level has potential as a novel biomarker for predicting cognitive impairment 30 days after AOPP.

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Section: Baseline Characteristics Of the Study Patientssupporting

confidence: 77%

Serum ubiquitin C‐terminal hydrolase L1 predicts cognitive impairment in patients with acute organophosphorus pesticide poisoning

Pang

Liu

et al. 2019

Clinical Laboratory Analysis

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“…However, this was not found in intracranial hemorrhage (43). It has been also revealed that increased serum levels of UCH-L1 reflect neuropathology, such as subcortical white matter lesion and increased level of UCH-L1 level in the CSF (44,45). Thus, UCH-L1 was suggested as an indicator of TBI.…”

Section: Discussionmentioning

confidence: 98%

Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin- Proteosome System in Autism Spectrum Disorder?

Çetin

Tezdig

Tarakçıoğlu

et al. 2017

Arch Neuropsychiatr

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“…Neurotransmitters epinephrine and norepinephrine, together with glucocorticoids such as cortisol, are regarded as stress hormones, and play a complex role in regulating cardiovascular function, energy-production and inflammation (Axelrod and Reisine 1984). UCHL1 is a neuron-specific protein that regulates ubiquitin protein modification, and has been implicated in brain injury (Li et al 2015; Zetterberg et al 2013). S100B is a glial-specific protein that is expressed primarily by astroglial cells (Zetterberg et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study

Liu

Urch

Szyszkowicz

et al. 2017

Environment International

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Background Epidemiological studies have reported associations between air pollution and neuro-psychological conditions. Biological mechanisms behind these findings are still not clear. Objectives We examined changes in blood and urinary neural biomarkers following exposure to concentrated ambient coarse, fine and ultrafine particles. Methods Fifty healthy non-smoking volunteers, mean age 28 years, were exposed to coarse (2.5-10 μm, mean 213 μg/m3) and fine (0.15-2.5 μm, mean 238 μg/m3) concentrated ambient particles (CAPs), and filtered ambient and/or medical air. Twenty-five participants were exposed to ultrafine CAP (mean size 59.6 nm, range 47.0-69.8 nm, mean 136 μg/m3) and filtered medical air. Exposures lasted 130 minutes, separated by ≥2 weeks, and the biological constituents endotoxin and β-1,3-D-glucan of each particle size fraction were measured. Blood and urine samples were collected pre-exposure, and 1-hour and 21-hour post exposure to determine neural biomarker levels. Mixed-model regressions assessed associations between exposures and changes in biomarker levels. Results Results were expressed as percent change from daily pre-exposure biomarker levels. Exposure to coarse CAP was significantly associated with increased urinary levels of the stress-related biomarkers vanillylmandelic acid (VMA) and cortisol when compared with exposure to filtered medical air [20% (95% confidence interval: 1.0%, 38%) and 64% (0.2%, 127%), respectively] 21 hours post exposure. However exposure to coarse CAP was significantly associated with decreases in blood cortisol [-26.0% (-42.4%, -9.6%) and -22.4% (-43.7%, -1.1%) at 1 hr and 21 hr post exposure, respectively]. Biological molecules present in coarse CAP were significantly associated with blood biomarkers indicative of blood brain barrier integrity. Endotoxin content was significantly associated with increased blood ubiquitin C-terminal hydrolase L1 [UCHL1, 11 % (5.3%, 16%) per ln(ng/m3+1)] 1-hour post exposure, while β-1,3-D-glucan was significantly associated with increased blood S100B [6.3% (3.2%, 9.4%) per ln(ng/m3+1)], as well as UCHL1 [3.1% (0.4%, 5.9%) per ln(ng/m3+1)], one-hour post exposure. Fine CAP was marginally associated with increased blood UCHL1 when compared with exposure to filtered medical air [17.7% (-1.7%, 37.2%), p=0.07] 21 hours post exposure. Ultrafine CAP was not significantly associated with changes in any blood and urinary neural biomarkers examined. Conclusion Ambient coarse particulate matter and its biological constituents may influence neural biomarker levels that reflect perturbations of blood-brain barrier integrity and systemic stress response.

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Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions

Cited by 10 publications

References 48 publications

Serum ubiquitin C‐terminal hydrolase L1 predicts cognitive impairment in patients with acute organophosphorus pesticide poisoning

Serum ubiquitin C‐terminal hydrolase L1 predicts cognitive impairment in patients with acute organophosphorus pesticide poisoning

Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin- Proteosome System in Autism Spectrum Disorder?

Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study

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