Changes of urinary phospholipids in the chronic kidney disease patients

Abstract

Our work first demonstrated that urinary phospholipids might be biomarkers for the chronic kidney disease patients. Increased urinary phospholipids in chronic kidney disease patients might result from proteinuria, damaged kidney function or proteinuria induced hypoalbuminemia or lipotoxicity.

Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease

“…Interestingly, the overall decreased PC observed in this study was apparently not suffi cient to cause major structural changes in the LDL, as there was no signifi cant change in the size of the LDL particles in CKD. The decrease in PCs observed is in agreement with a previous report on levels of PC in plasma of ESRF patients ( 43 ), and also with the observation that PCs are lost in urine of patients with CKD ( 44 ). The lower levels of STs and CSs in LDL of CKD patients are in agreement with some previous studies ( 17 ).…”

DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules

“…For instance, a decreasing trend of PI biomarker, PI (40:6), in the plasma was identified for type II DKD (Zhu et al 2011). A number of studies have demonstrated the abnormal lipid metabolism in the pathogenesis of DKD, however, the changing directions of different phospholipid classes (e.g., PEs, PGs, PIs, and PSs) are diverse in plasma/serum, urine, or renal extracts (Yang et al 2013;Zhao et al 2015;Zhu et al 2011). Several investigators reported that accumulation of lipids in kidney played a pivotal role in the pathobiology of DKD (Herman-Edelstein et al 2014;Wang et al 2005;Zhao et al 2015).…”

Plasma lipidomics reveal profound perturbation of glycerophospholipids, fatty acids, and sphingolipids in diet-induced hyperlipidemia

“…Comprehensive characterization of renal diseases could provide important and integrative information to better characterize molecular relationships underlying this pathophysiology in order to develop more reliable and specific markers for diagnosis, prognosis, prevention, and therapeutic response [2,24]. The growth of systems biology and development of new experimental and computational tools have enabled the connection of gene-cell-organ regulatory mechanisms at multiple levels to integrate the molecular and cell biology of kidney structure and function [25][26][27][28][29]. Lipids play diverse and important roles in biologic systems including membrane bilayer structure, energy storage, signal transduction, and also provide functional support for membrane proteins and their interactions [30].…”