2013
DOI: 10.3390/medicina49030021
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Changes of Visual Functions in Patients With Pituitary Adenoma

Abstract: Background and Objective. The aim of this study was to evaluate associations between visual functions (visual acuity, perimetry, optic nerve disc condition, and color contrast sensitivity) and pituitary adenoma (PA) diameter. Material and Methods. In the study, 20 patients with PA, which was confirmed by computed tomography or magnetic resonance imaging scans, were examined. The patients were divided into 2 groups: those with a PA diameter of ≤1 cm (14 eyes) and with a PA diameter of >1 cm (26 eyes). The co… Show more

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Cited by 15 publications
(14 citation statements)
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“…The importance of MMP-2 (-1306) gene polymorphism in the susceptibility of various tumours has been shown in numerous studies [ 47 – 50 ]. In addition, MMP-2 has been shown to be overexpressed in PA [ 5 , 39 , 40 ]. On the basis of these findings, we sought to examine whether the polymorphism in the MMP2 (-1306) promoter could have an impact on the risk of PA development.…”
Section: Discussionmentioning
confidence: 99%
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“…The importance of MMP-2 (-1306) gene polymorphism in the susceptibility of various tumours has been shown in numerous studies [ 47 – 50 ]. In addition, MMP-2 has been shown to be overexpressed in PA [ 5 , 39 , 40 ]. On the basis of these findings, we sought to examine whether the polymorphism in the MMP2 (-1306) promoter could have an impact on the risk of PA development.…”
Section: Discussionmentioning
confidence: 99%
“…To our knowledge, there are no studies which have explored the relationship between the polymorphisms in MMP2 -1306 C/T and the development of PA. However, several studies have analyzed MMP-2 expression in PA [ 5 , 39 , 40 ]. Liu et al [ 39 ] have found that the MMP-2 score of PAs with cavernous sinus invasion (3.9 ± 0.5) was significantly higher than those without invasion (2.3 ± 0.2; p < 0.01).…”
Section: Discussionmentioning
confidence: 99%
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“…In the present study, the results were determined according to PA diameter. The PA diameter was 131.79 in patients with PA ≤1 cm (SD, 30.62), while that of patients with PA >1 cm was 244.68 (SD, 51.56; p = 0.011) [ 26 ]. Jayaraman et al [ 22 ] also found color vision impairment in one or both eyes in patients with PA. Gupta et al [ 27 ] interpreted the alterations of color contrast sensitivity in patients with hypophysis adenoma as a decrease in the myelination of the vision fibers due to altered nutrition.…”
Section: Discussionmentioning
confidence: 99%