2000
DOI: 10.1002/(sici)1522-2683(20000301)21:4<753::aid-elps753>3.0.co;2-y
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Changes of α1-acid glycoprotein microheterogeneity in acute inflammation stages analyzed by isoelectric focusing using serum obtained postoperatively

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Cited by 29 publications
(10 citation statements)
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“…The spectrum of the intact glycoprotein from pooled plasma revealed both the structural information as well as the quantities of the glycan chains attached to the protein core. Varying amounts of fucose and sialic acid correlate with physiological conditions as well as development and progression of various diseases. , ,, This fast and reliable method could be used for, for example, monitoring clinical samples or identifying genetic variants including a relative quantification of glycan compositions.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The spectrum of the intact glycoprotein from pooled plasma revealed both the structural information as well as the quantities of the glycan chains attached to the protein core. Varying amounts of fucose and sialic acid correlate with physiological conditions as well as development and progression of various diseases. , ,, This fast and reliable method could be used for, for example, monitoring clinical samples or identifying genetic variants including a relative quantification of glycan compositions.…”
Section: Discussionmentioning
confidence: 99%
“…Nearly half of its mass originates from glycosylation of five N -glycosylation sites, leading to a 40 kDa glycoprotein with a very low pI ranging from 2.8 to 3.8, caused mainly by its high amount of sialic acid (Figure ). , It has been shown that its biological functions are highly dependent on the glycosylation presented on the proteins. Hence, a change in glycosylation due to physiological condition like pregnancy or inflammation has been reported. , An altered glycosylation of human AGP was also observed in a variety of cancer diseases like hepatocellular carcinoma, ovarian carcinoma, lung cancer or pancreatic cancer, and other diseases such as rheumatic arthritis. Observed changes include an increased expression of the Lewis X motive, increased or decreased sialylation, and branching.…”
Section: Introductionmentioning
confidence: 99%
“…A representative experiment is shown. not rule out a much stronger contribution of these proteins to the observed effects in vivo, as they may become modified during either inflammatory and/or malignant diseases, giving them properties potentially quite different from the commercially available proteins isolated from healthy donors (43).…”
Section: Discussionmentioning
confidence: 99%
“…The major inducer of CRP synthesis is IL-6. Likewise, Iijima et al (40) stated that the high level of IL-6 was found in stomach cancer patients. In addition, CRP is the fastest responder of the acute phase proteins during the infection.…”
Section: Discussionmentioning
confidence: 99%