Changes on cerebral antioxidant enzymes, peroxidation, and the glutathione system of frogs after aging and catalase inhibition

Quiroga, G. Barja de; Pérez‐Campo, R.; López-Torres, Mónica

doi:10.1002/jnr.490260314

Cited by 14 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal experiment data support the role of this alteration in brain oxidant defense systems . Hydrogen peroxide increase was due either to oral consumption (Benzi et al, 1990) or inhibition of CAT activity by 3-amino-1,2,4-triazole (Sinet et al ., 1980) and diethyldithiocarbamate (Barjo de Quiroga et al, 1990) .…”

Section: Caudate Nucleusmentioning

confidence: 99%

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

Gsell¹,

Conrad²,

Hickethier³

et al. 1995

Journal of Neurochemistry

158

View full text Add to dashboard Cite

“Oxidative stress” may be of significance in the etiopathogenesis of dementia of Alzheimer type (DAT). Therefore, we measured activities of the enzymes superoxide dismutase (SOD) and catalase (CAT), which detoxicate reactive oxygen species. Enzyme activities were measured postmortem in basal ganglia, cortical, and limbic brain regions of patients with DAT and age‐matched controls. SOD activity increased with age in basal nucleus of Meynert. However, there was no significant difference in SOD activity between DAT and controls. CAT activity was independent of age and postmortem time. There were significant reductions in CAT activity in parietotemporal cortex, basal ganglia, and amygdala in DAT compared with controls (p < 0.05 to 0.01). Our findings are in line with the assumption that reactive oxygen species could contribute to the pathogenesis of DAT. Absence of these changes in basal nucleus of Meynert might reflect retrograde degeneration of cholinergic fibers.

show abstract

Section: Caudate Nucleusmentioning

confidence: 99%

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

Gsell¹,

Conrad²,

Hickethier³

et al. 1995

Journal of Neurochemistry

158

View full text Add to dashboard Cite

show abstract

“…The main failure in application of markers of oxidative stress with feral fish is expected adaptation to the environmental conditions that leads to compensatory homeostasis occuring in antioxidant system (Barja de Quiroga et al, 1990;Regoli & Principato, 1995;Reynders et al, 2008). The choice of end points in the field studies of fish may be complicated by a history of exposure to xenobiotics causing oxidative stress.…”

Section: Poisoning and Adaptation: Caged Fishmentioning

confidence: 99%

Environmental Pollution and Oxidative Stress in Fish

Stoliar¹,

Lushchak²

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

View full text Add to dashboard Cite

Brain glutathione reductase induction increases early survival and decreases lipofuscin accumulation in aging frogs

López-Torres

Pérez‐Campo

Fernández

et al. 1993

J of Neuroscience Research

Self Cite

View full text Add to dashboard Cite

Brain catalase was continuously depleted throughout the life span starting with a large population of initially young and old frogs. Free radical-related parameters were measured in the brain tissue once per year after 2.5, 14.5, and 26.5 months of experimentation. Brain lipofuscin accumulation was observed after 14.5 and 26.5 months, and survival was continuously followed during 33 months. The age of the animal did not decrease endogenous antioxidants nor increase tissue peroxidation either in cross-sectional or longitudinal comparisons. Continuous catalase depletion similarly affected young and old animals, inducing glutathione reductase, tending to decrease oxidized glutathione/reduced glutathione (GSSG/GSH) ratio, decreasing lipofuscin accumulation in the brain, and increasing survival from 46% to 91% after 14.5 months. At 26.5 months of experimentation the loss of the glutathione reductase induction in catalase-depleted animals was accompanied by the presence of higher lipofuscin deposits than in controls and was followed by a great increase in mortality rate. Even though the maximal life span (7 years) was the same in the control and treated animals which were already old (4.2 years) at the beginning of the experiment, the treated animals showed a strong reduction in the rates of early death. It is proposed that the maintenance of a high antioxidant/prooxidant balance in the vertebrate brain greatly increases the probability of the individual to reach the final segments of its species-specific life span.

show abstract

Changes on cerebral antioxidant enzymes, peroxidation, and the glutathione system of frogs after aging and catalase inhibition

Cited by 14 publications

References 38 publications

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

Environmental Pollution and Oxidative Stress in Fish

Brain glutathione reductase induction increases early survival and decreases lipofuscin accumulation in aging frogs

Contact Info

Product

Resources

About