Changes Produced by a Pneumatic Tourniquet

Ochoa, J.; Fowler, Thomas J.; Gilliatt, R. W.

doi:10.1159/000394086

Cited by 6 publications

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“…These cases, however seem to be very similar to the disease under discussion. erted upon a healthy nerve, whose mechanism of formation is connected with the shifting of the node of Ranvier [ 1,11,12]. The shifting of the nodes of Ranvier was not observed in our study.…”

Section: Discussionmentioning

confidence: 47%

Familial neuropathy with liability to pressure palsies. Report of a Case

Jedrzejowska

Hausmanowa-Pétrusewicz

1981

Ital J Neuro Sci

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A case of hereditary neuropathy with liability to pressure palsies is described. The main histological findings in sural nerve were focal thickenings of myelin-"sausages", "tomaculae"-and wide variability of internodal length. Numerous fibers with signs of remyelination were present, while there was little evidence of active demyelination. There were moderate axonal changes. Electrophysiological study revealed slowed conduction velocity in peripheral nerves. The possibility of a congenital myelin defect in this disease is discussed.

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Section: Discussionmentioning

confidence: 47%

Familial neuropathy with liability to pressure palsies. Report of a Case

Jedrzejowska

Hausmanowa-Pétrusewicz

1981

Ital J Neuro Sci

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“…The functional importance of the integrity of the paranode has also been established by studies showing that even minor lesions of the paranodal myelin are effective in slowing impulse conduction (Koles and Rasminsky, 1972;Rasminsky and Sears, 1972). Furthermore, a complete conduction block can be caused not only by advanced paranodal demyelination (Ochoa et al, 1973) but also by slight paranodal changes (Shahani and Sumner, 19811, presumably because of shunts in the transverse-band-limited paranodal spiral pathway, thereby lowering its impedance. Conduction block has also been noted in association with nodal and paranodal deposits of anti-GM1 antibodies in a human sural nerve (Santoro et al, 1990).…”

Section: Gliding Of Terminal Loops In Relation To the Axolemmamentioning

confidence: 99%

Developmental and pathological changes at the node and paranode in human sural nerves

1996

Microsc. Res. Tech.

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The nodes and paranodes of peripheral nerve fibers are complex structures that are especially prone to artificial and pathological changes which have to be distinguished from normal developmental changes. Alterations during normal development are mainly caused by an increase in axonal diameter and myelin sheath thickness. The nodal, and paranodal axon diameters in human sural nerves reach their adult values at 3–5 years of age, simultaneously to the internodal diameter. The ratio between internodal and paranodal axon diameters remain relatively constant, with an average value of 1.8 to 2.0 (range: 1.6 to 2.5). Despite a considerable increase of the number of myelin lamellae, the length of the paranodal myelin sheath attachment zone at the axon does not increase correspondingly, because of (1) attenuation of the terminal myelin loops, (2) separation of some of these from the axolemma, and their piling up in the paranode. Separation of variable numbers of terminal myelin loops from the underlying axolemma results in the formation of the spines on the “double bracelet épineux” of Nageotte, while the transverse bands of these loops disappear. The adaptation of the paranodal myelin sheath to axonal expansion during development probably occurs by uneven gliding of the paranodal myelin loops simultaneously with internodal slippage of myelin lamellae. Artificial changes are caused by insufficient fixation or mechanical stress during excision and further handling (cutting, dedydrating, embedding) of nerves whereas pathological changes may be induced by a multitude of causes. An attempt to classify these changes is presented in Table 2. © 1996 Wiley‐Liss, Inc.

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Conduction in Abnormal Nerve

Brown

1984

The Physiological and Technical Basis of Electromyography

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Changes Produced by a Pneumatic Tourniquet

Cited by 6 publications

References 0 publications

Familial neuropathy with liability to pressure palsies. Report of a Case

Familial neuropathy with liability to pressure palsies. Report of a Case

Developmental and pathological changes at the node and paranode in human sural nerves

Conduction in Abnormal Nerve

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