Interventions challenging alcohol expectancies may lead to reductions in alcohol consumption. We conducted a meta-analysis to examine the efficacy of alcohol expectancy challenge (EC) interventions for college alcohol abuse prevention. Included were 14 studies (19 EC interventions) that measured alcohol expectancies and consumption, provided sufficient information to calculate effect sizes, and were available as of June 2010 (N = 1,415; M age = 20; 40% women; 88% White). Independent raters coded participant characteristics, design and methodological features, and intervention content, and calculated weighted mean effect sizes at first follow-up, using both fixed- and random-effects models. Compared to controls, EC participants reported lower positive alcohol expectancies, reduced their alcohol use, and reduced their frequency of heavy drinking (d+s ranged from 0.23 to 0.28). Within-group improvements in alcohol expectancies and consumption emerged for the EC group only; relative to their own baseline, EC participants reported lower positive alcohol expectancies, reduced their alcohol use, and reduced their frequency of heavy drinking (d+s range from 0.13 to 0.36). Supplemental analyses found improvements in specific alcohol expectancies (social, sexual, tension, and arousal) both between- and within-group. The short-term effects of EC interventions on college student drinking are not maintained at follow-ups greater than 4 weeks.