Changing incidence of acute pancreatitis: 10‐year experience at the Royal Children's Hospital, Melbourne

Nydegger, Andreas; Heine, Ralf G.; Ranuh, Reza Gunadi; Gegati-Levy, Ricardo; Crameri, Joe; Oliver, Mark

doi:10.1111/j.1440-1746.2007.04936.x

Cited by 190 publications

(183 citation statements)

References 22 publications

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“…The rate of childhood AP reported here for the UK was lower than that reported for Australia (2.5/100,000 in 1993 and 3.6/100,000 in 2002), 6 and the USA (2.4/100,000 in 1993 and 13.2/100,000 in 2004). 3 However, both of these studies were retrospective reviews conducted at major paediatric referral centres and the cases of AP were detected by either reviewing hospital laboratory databases, 6 or hospital discharge records. 3 The retrospective nature, referral bias and variation in the diagnostic criteria and age groups of these studies may explain these differences.…”

Section: Discussioncontrasting

confidence: 77%

“…1 AP is uncommon in children, but leads to significant morbidity in the short, medium and long-term. Recently, an increase in the number of paediatric AP cases in single institutions has been reported by centres in the USA, [2][3][4][5] Australia, 6 and Mexico. 7 However, these studies are retrospective reviews and the incidence of AP is usually reported as an absolute number of cases per centre per year at individual referral institutions.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and Clinical Associations of Childhood Acute Pancreatitis

et al. 2016

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Financial Disclosure: The authors have no financial relationships relevant to this article to disclose. Conflict of Interest:The authors have no conflicts of interest relevant to this article to disclose. What's Known on This Subject: Acute pancreatitis in childhood is a relatively rare but potentially serious condition. In the past, trauma and mumps have been the commonest associations. No study has ever estimated incidence within a childhood population on a prospective basis. AbbreviationsWhat This Study Adds: Acute pancreatitis has a childhood incidence in the UK of 0.78 per 100,000/year (95%CI 0.62-0.96). Gallstones and drug therapy are now the most commonly identified associations whilst mumps and trauma are identified rarely. Children of Pakistani heritage are disproportionately affected. Contributors' Statements:Abdalmonem Majbar: Dr Majbar helped with designing the data collection instruments, collected the data, conducted all analyses, drafted the initial manuscript, and approved the final manuscript as submitted.Eleri Cusick and Paul Johnson: Ms Cusick and Professor Johnson contributed to study conceptualization and design, took part in data interpretation, critically reviewed the manuscript, and approved the final manuscript as submitted.Richard Lynn: Mr Lynn contributed to study conceptualization and design, critically reviewed the manuscript, and approved the final manuscript as submitted.Linda Hunt: Dr Hunt supported and contributed to the statistical analysis, critically reviewed the manuscript, and approved the final manuscript as submitted.Julian Shield: Professor Shield conceptualized and designed the study, supervised and assisted data collection and analyses, critically reviewed the manuscript, and approved the final manuscript as submitted.All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. Results: 94 cases (48 boys) fulfilled the diagnostic criteria. The median age at diagnosis was 11.2 years (range 1.3-14.9). White children accounted for 61% of the cases compared to 28% from Asian and 5% from African ethnicities. Pakistani children accounted for 18 of 26 (69%) Asian patients and 19% of the total cohort. The incidence of AP in children in the UK was 0.78 per 100,000/year (95%CI 0.62-0.96). The incidence in Pakistani children (4.55; 95%CI 2.60-7.39) was 7-fold greater than White children (0.63; 95%CI 0.47-0.83). Of the 94 cases: 35 (37%) were idiopathic or associated with drugs 18 (19%), gallstones 12 (13%), hereditary 7 (7%), organic acidaemias 7 (7%), anatomical anomalies 5 (5%), viral infections 3 (3%), systemic diseases 2 (2%) and trauma 1 (1%). The most common drug associations were asparaginase (28%), azathioprine (17%) and sodium valproate (17%). Conclusions:Whilst still relatively uncommon in the U...

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Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Incidence and Clinical Associations of Childhood Acute Pancreatitis

et al. 2016

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“…Actualmente, la mortalidad descrita es de alrededor de un 10% 2,3 . Artículos recientes señalan que la incidencia de la PA en niños ha aumentado en los últimos años 2,4 .…”

Section: Introductionunclassified

“…Actualmente, la mortalidad descrita es de alrededor de un 10% 2,3 . Artículos recientes señalan que la incidencia de la PA en niños ha aumentado en los últimos años 2,4 . Las causas más frecuentes de PA en pediatría son el trauma, las enfermedades sistémicas, el uso de drogas, la PA idiopática y la patología biliar, incluyendo alteraciones anatómicas de la vía biliar y litiasis 2,5,6 .…”

Section: Introductionunclassified

“…Artículos recientes señalan que la incidencia de la PA en niños ha aumentado en los últimos años 2,4 . Las causas más frecuentes de PA en pediatría son el trauma, las enfermedades sistémicas, el uso de drogas, la PA idiopática y la patología biliar, incluyendo alteraciones anatómicas de la vía biliar y litiasis 2,5,6 . Existe consenso en que la PA idiopática ocupa un lugar relevante en la lista de causas (en ocasiones, primer lugar), postulándose mutaciones en genes involucrados en la secreción pancreática como una explicación plausible 7 .…”

Section: Introductionunclassified

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